Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium / Edition 1

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Overview

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following:

  • What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
  • Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
  • Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?

Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

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Editorial Reviews

Doody's Review Service
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the proceedings of a symposium focused on using gene sequences to try to answer major issues in immunology sponsored by the Novartis Foundation held in March 2006. Included are the discussions among the participants that grew out of each presentation.
Purpose: According to Dr. Chris Goodnow who proposed the symposium, its purpose was to describe ways to use genome sequencing to understand some of the big issues in immunology. In other words, the data presented at the meeting and described in this book should help in figuring out what gene sequences encode different kinds of responses and what sorts of approaches work well to define immunological mechanisms. Judging by the kinds of discussions that were held, the meeting accomplished these goals and the chapters could provide some helpful information.
Audience: The idea behind the original symposium and this book targets primarily researchers and clinicians with a particular interest in pathways of regulation. The participants are authorities in the subjects that they presented and thus the information could be useful to anyone working in these areas.
Features: Several chapters focus on different infectious diseases. Other chapters cover systems genetics, systemic autoimmunity, and immune cell migration. The discussions following each chapter raise some intriguing points and are likely to be of interest to some researchers. This is the kind of book that one hopes to find available in the library because it is a good reference. It's less likely to be a book that one reads from cover to cover because not every chapter will be of interest. Although there was an overriding theme to the meeting, there is still a somewhat fragmented feeling to the book.
Assessment: For anyone who would have liked to be part of the meeting and ensuing discussions, the book provides some important information. For someone who was fortunate enough to attend the meeting, the book appears to be a good summary of the material that was presented.
From the Publisher
"…useful to…researchers and clinicians with a particular interest in pathways of regulation." (Doody's Health Services)
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Product Details

  • ISBN-13: 9780470027554
  • Publisher: Wiley
  • Publication date: 5/4/2007
  • Series: Novartis Foundation Symposia Series , #278
  • Edition number: 1
  • Pages: 232
  • Product dimensions: 6.38 (w) x 9.51 (h) x 0.65 (d)

Meet the Author

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

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Table of Contents

Introduction (Chris Goodnow).

Transcriptional regulatory networks in macrophages. (David A. Hume, Christine A. Wells and Timothy Ravasi).

Discussion.

The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions (Christian Schönbach).

Discussion.

Molecular pathways for lymphangiogenesis and their role in human disease (Steven A. Stacker, Rae H. Farnsworth, Tara Karnezis, Ramin Shayan,.

Darrin P. Smith, Karri Paavonen, Natalia Davydova, Carol Caesar,.

Rachael Inder, Megan E. Baldwin, Bradley K. McColl, Sally Roufail,.

Richard A. Williams, Richard A. Hughes, Kari Alitalo and.

Marc G. Achen).

Discussion.

General discussion I.

Specifying the patterns of immune cell migration (Jason G. Cyster).

Discussion.

Human monogenic disorders that confer predisposition to specifi c infections (Capucine Picard, Laurent Abel and Jean-Laurent Casanova).

Discussion.

The genetic control of susceptibility to Mycobacterium tuberculosis (W. J. Britton, S. L. Fernando, B. M. Saunders, R. Sluyter and J. S. Wiley).

Discussion.

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes (Bernard Malissen, Ying Wang, Michael Mingueneau and Marie Malissen).

Discussion.

Genetic analysis of systemic autoimmunity (Carola G. Vinuesa and Matthew C. Cook).

Discussion.

Genetic resistance to smallpox: lessons from mousepox (Gunasegaran Karupiah, Vijay Panchanathan, Isaac G. Sakala and Geeta Chaudhri).

Discussion.

The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes (Anny Fortin, Eduardo Diez, Janet E. Henderson, Jeffrey S. Mogil, Philippe Gros and Emil Skamene).

Discussion.

Genetic control of host–pathogen interactions in mice (Gundula Min-Oo, Mary M. Stevenson, Anny Fortin and Philippe Gros).

Discussion.

Mycobacterium tuberculosis and its ability to resist immunity (Douglas Young and Anne O’Garra).

Discussion.

Systems genetics: the next generation in genetics research? (Grant Morahan and Robert W. Williams).

Discussion.

Regulation of the immune system in metazoan parasite infections (Rick Maizels).

Discussion.

Closing remarks (Chris Goodnow).

Contributor Index.

Subject Index.

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