Defining Optimal Immunotherapies for Type 1 Diabetes: Novartis Foundation Symposium / Edition 1

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More About This Textbook


"Since T1D is an autoimmune disease, a likely strategy in the search for a cure seems to be modulation of the immune system. This book therefore brings together contributions from leaders in the arena of clinical immunotherapy, not limited to the diabetes field." Defining Optimal Immunotherapies For Type 1 Diabetes offers a comprehensive and up-to-date account of immunological strategies for preventing or treating T1D, and will be of particular interest to diabetologists and endocrinologists, both clinicians and researchers, as well as to immunologists and molecular or cell biologists and drug discovery scientists. The book also considers T1D within the broader context of autoimmune disease, and is therefore of interest to clinicians and researchers working on any such disease.
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Product Details

  • ISBN-13: 9780470723258
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/23/2008
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 222
  • Product dimensions: 5.80 (w) x 9.00 (h) x 0.70 (d)

Table of Contents

Pancreatic pathology in type 1 diabetes in human Alan K. Foulis Foulis, Alan K. 2

The [beta] cell population in type 1 diabetes Daniel Pipeleers Pipeleers, Daniel Peter In 't Veld Veld, Peter In 't Miriam Pipeleers-Marichal Pipeleers-Marichal, Miriam Frans Gorus Gorus, Frans 19

Bone marrow expressing a diabetes resistance MHC class II allele : diabetes deviation by chronic immune stimulation Peter Reifsnyder Reifsnyder, Peter William Schott Schott, William Darcy Pomerleau Pomerleau, Darcy Mark D. Lessard Lessard, Mark D. Brian W. Soper Soper, Brian W. Edward H. Leiter Leiter, Edward H. 32

Resuscitating adaptive Tregs with combination therapies? Damien Bresson Bresson, Damien Matthias von Herrath von Herrath, Matthias 50

Cytotoxic T cell mechanisms of [beta] cell destruction in non-obese diabetic mice Thomas W. H. Kay Kay, Thomas W. H. Nadine L. Dudek Dudek, Nadine L. Kate Graham Graham, Kate Eugene Estella Estella, Eugene Eveline Angstetra Angstetra, Eveline Mark D. McKenzie McKenzie, Mark D. Jan Allison Allison, Jan Helen E. Thomas Thomas, Helen E. 68

Type 1 diabetes : chronic progressive autoimmune disease Li Zhang Li, Zhang Roberto Gianani Gianani, Roberto Maki Nakayama Nakayama, Maki Edwin Liu Liu, Edwin Masakazu Kobayashi Kobayashi, Masakazu Erin Baschl Baschl, Erin Liping Yu Yu, Liping Sunanda Babu Babu, Sunanda Abby Dawson Dawson, Abby Kelly Johnson Johnson, Kelly Mohamed Jahromi Jahromi, Mohamed Therese Aly Aly, Therese Pamela Fain Fain, Pamela Jennifer Barker Barker, Jennifer Marian Rewers Rewers, Marian George S. Eisenbarth Eisenbarth, George S. 85

Current and past prevention and intervention trials in type 1 diabetes Teodora Staeva Staeva, Teodora 99

CD8and cytotoxic T cells in type 1 diabetes Mark Peakman Peakman, Mark 113

General discussion I 122

General discussion II 126

Genetic and therapeutic control of diabetogenic CD8* T cells Pere Santamaria Santamaria, Pere 130

General discussion III 141

Towards a curative therapy in type 1 diabetes : remission of autoimmunity, maintenance and augmentation of [beta] cell mass Frank Waldron-Lynch Waldron-Lynch, Frank Matthias von Herrath von Herrath, Matthias Kevan C. Herold Herold, Kevan C. 146

Immune markers of disease and therapeutic intervention in type 1 diabetes Bart O. Roep Roep, Bart O. 159

Re-establishing immune tolerance in type 1 diabetes via regulatory T cells Silvia Gregori Gregori, Silvia Manuela Battaglia Battaglia, Manuela Maria-Grazia Roncarolo Roncarolo, Maria-Grazia 174

Translating mucosal antigen based prevention of autoimmune diabetes to human Ezio Bonifacio Bonifacio, Ezio Anette Ziegler Ziegler, Anette Peter Achenbach Achenbach, Peter Jennifer Barker Barker, Jennifer George S. Eisenbarth Eisenbarth, George S. 187

Closing remarks Matthias von Herrath von Herrath, Matthias 202

Index of contributors 204

Subject index 206

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