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Doody's Review ServiceReviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This atlas of brain neuropathology in dementing illnesses correlates the clinical aspects of dementing illness with the pathological.
Purpose: The purpose is to provide an atlas of brain neuropathology in dementing illnesses and in doing so, to give a rapid and current view of evolving concepts of the natural history of dementing illnesses. These are worthy objectives and the authors meet them head on.
Audience: The audience includes neuropathologists, neurologists, and those caring for demented persons. The authors are all experts in the area.
Features: Descriptions of clinical and cognitive aspects of aging are followed by chapters on the pathology seen in normal aging and in vascular and other forms of dementia. The pathology of Alzheimer's disease is extensively demonstrated as is the area of very early dementing illnesses. The copious photomicrographs of brain tissue and sections of the brain are very well selected and gorgeous in their presentation.
Assessment: This book, like all great atlases, entices us with the images, which draw us in and affect our cognition and understanding, surpassing words. Here the words are melded with the images. The understanding of the correlation of clinical mental status testing in evaluating Alzheimer's disease with what is actually happening in the brain at each of the stages has substantially moved the field forward. The intersection of normal brain aging, mild cognitive dysfunction, and preclinical Alzheimer's disease is still not fully understood. The brain specimens taken from this uncertain region are utterly tantalizing and engrossing. This is a marvelous teaching tool as well.