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This book reviews the latest scientific research and seeks to establish whether dementia, particularly Alzheimer's disease, is distinct from the normal aging process or on a continuum with normal aging. With contributions from leading neurobiologists, psychologists, clinicians, and epidemiologists, this volume makes a major advance in the understanding of dementia and the aging mind and brain. It also has wide implications for areas as diverse as dementia research strategy, treatment and prevention, social attitudes, and health policy.
The book contains predominantly black-and-white illustrations, with one color illustration.
| List of contributors | ||
| Foreword | ||
| Preface | ||
| Acknowledgements | ||
| 1 | What is the relationship between dementia and normal aging? | 3 |
| 2 | Dementia and aging since the nineteenth century | 15 |
| 3 | The history of research into dementia and its relationship to current concepts | 41 |
| 4 | The relationship between dementia and normal aging of the brain | 57 |
| 5 | International criteria and differential diagnosis | 79 |
| 6 | Mild dementia: a clinical perspective | 91 |
| 7 | Neurological aspects of dementia and normal aging | 118 |
| 8 | Imaging and dementia | 130 |
| 9 | How common are cognitive impairment and dementia? An epidemiological viewpoint | 167 |
| 10 | What are the risk factors for dementia? | 208 |
| 11 | How do risk factors for dementia relate to current theories on mechanisms of aging? | 230 |
| 12 | A method for measuring dementia as a continuum in community surveys | 244 |
| 13 | The meaning of dementia to those involved as carers | 257 |
| 14 | Personality and behaviour in dementia and normal aging | 272 |
| 15 | Memory function in dementia and normal aging - dimension or dichotomy? | 291 |
| 16 | Language in dementia and normal aging | 331 |
| 17 | Visuospatial dysfunction in dementia and normal aging | 366 |
| 18 | Dementia and normal aging: neuropathology | 385 |
| 19 | Cholinergic component of dementia and aging | 437 |
| 20 | Molecular characterization of the neurodegenerative changes which distinguish normal aging from Alzheimer's disease | 470 |
| 21 | Genetic linkage in Alzheimer's disease | 492 |
| 22 | Health-care policy and planning for dementia: an international perspective | 519 |
| 23 | Public health implications of a continuum model of dementia | 552 |
| Index | 561 |
Overview
This book reviews the latest scientific research and seeks to establish whether dementia, particularly Alzheimer's disease, is distinct from the normal aging process or on a continuum with normal aging. With contributions from leading neurobiologists, psychologists, clinicians, and epidemiologists, this volume makes a major advance in the understanding of dementia and the aging mind and brain. It also has wide implications for areas as diverse as dementia research strategy, treatment and prevention, social ...