Dementia with Lewy Bodies: Clinical, Pathological, and Treatment Issues

by Robert Perry, Ian McKeith, Elaine Perry, Jeffrey L. Cummings

Overview

Dementia with Lewy bodies (DLB) is among the most common causes of degenerative dementia. This book, which represents the first authoritative statement about DLB, includes review articles, case studies, and recent research findings from the leading researchers of DLB. The aims of this volume are to establish clinical diagnostic criteria and pathological protocols for DLB, and to explore evidence indicating that DLB patients may be responsive to symptomatic therapy. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry, and treatment of DLB, this is a landmark publication in clinical neuroscience.

Product Details

ISBN-13:	9780521561884
Publisher:	Cambridge University Press
Publication date:	11/28/1996
Edition description:	New Edition
Pages:	541
Product dimensions:	6.22(w) x 9.25(h) x 1.34(d)

About the Author

Perry, Robert H. (Newcastle General Hospital); McKeith, Ian G. (Univ of Newcastle upon Tyne); Perry, Elaine K. (Newcastle General Hospital)

The contributors represent the specialties of clinical neurobiology, neurodegenerative diseases, neuropathology, psychiatry, old age psychiatry, neurology, and clinical psychology. Most are from universities, academic medical centers, and reserch institutes in ten countries, including the U.K., the U.S., Japan, and Germany. Institutions prominently represented include J. W. Goethe Univ, Newcastle General Hospital, Albert Einstein Coll of Medicine, Univ of British Columbia, and UCLA.

Table of Contents

1. Introduction; Part I. Clinical Issues: 2. The clinical diagnosis and misdiagnosis of Lewy body dementia; 3. The nosological status of Lewy body dementia; 4. Putative clinical and genetic antecedents of dementia associated with Parkinson's disease; 5. Clinical features of patients with Alzheimer's disease and Lewy bodies; 6. The nature of the cognitive decline in Lewy body dementia; 7. Non-cognitive symptoms in Lewy body dementia; 8. Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia; 9. Neuropsychological aspects of Lewy body dementia; 10. The neuroanatomical basis of cognitive deficits in Lewy body dementia; 11. The clinical and functional imaging characteristics of Parkinsonian-dementia; 12. Positron emission tomography findings in Parkinson's disease and Lewy body dementia; 13. Clinical features of diffuse Lewy body disease in the elderly: analysis of 12 cases; 14. Senile dementia of Lewy body type - clinical features and prevalence in neuropathological postmortems; 15. Lewy body dementia in clinical practice; resume of clinical workshop sessions; Part II. Pathological Issues: 16. Pathological significance of Lewy bodies in dementia; 17. Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies; 18. What is the neuropathological basis of dementia associated with Lewy bodies?; 19. Cytoskeletal and Alzheimer-type pathology in Lewy body disease; 20. Diffuse Lewy body disease within the spectrum of Lewy body disease; 21. Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease and senile dementia of Alzheimer type; 22. Pathological and clinical features of Parkinson's disease with and without dementia; 23. Dementia with Lewy bodies: relationship to Parkinson's and Alzheimer's diseases; 24. What do Lewy bodies tell us about dementia and Parkinsonism?; 25. Pathogenesis of the Lewy body; 26. Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease; 27. Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia - an epiphenomenon?; 28. Genetic correlations in Lewy body disease; resume of pathological workshop sessions; Part III. Treatment Issues: 29. Psychopharmacology of cognitive impairment in Parkinson's disease; 30. Management of the non-cognitive symptoms of Lewy body dementia; 31. Altered consciousness and transmitter signalling in Lewy body dementia; 32. Cholinergic therapy and Lewy body dementia; 33. Clinical heterogeneity in dementia; responders to cholinergic therapy; 34. Tacrine and symptomatic treatment in Lewy body dementia; 35. Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms; 36. Neurotrophins and the cholinergic system in dementia; 37. Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinson's disease; Resume of treatment workshop Sessions; Appendix.

Editorial Reviews

"...strongly recommended for clinical and basic investigators with interests in the broad field of neurodegeneration or those specifically working in the fields of behavioural neurology, neuropsychiatry, movement disorders and neuropharmacology." Anthony E. Lang, Canadian Journal of Neurological Sciences

From the Publisher