The Demon in the Freezer: A True Story [NOOK Book]

Overview

“The bard of biological weapons captures
the drama of the front lines.”

-Richard Danzig, former secretary of the navy

The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot ...

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The Demon in the Freezer: A True Story

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Overview

“The bard of biological weapons captures
the drama of the front lines.”

-Richard Danzig, former secretary of the navy

The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.

Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.

Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.

Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.

From the Hardcover edition.

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Editorial Reviews

From Barnes & Noble
Richard Preston returns to the gruesome realm of infectious diseases with a story even more disturbing than the one told in his bestselling The Hot Zone. As with his previous book, Preston applies his incredible storytelling ability to a harrowing subject matter that is sure to once again terrify even the master thrillmeister Stephen King (who called The Hot Zone "one of the most horrifying things I've ever read in my whole life"). The "demon in the freezer" of the title refers to the two official smallpox stocks kept by the Centers for Disease Control in the United States and by Vector in Russia, but the greatest demon is the possibility of a weaponized super-pox. This important book should be read by all concerned citizens.
The New York Times Book Review
[Preston] has probably done more than any other writer to establish a nationwide imperative to think about infectious agents as global threats and potential weapons.
Publishers Weekly
Never mind Ebola, the hemorrhagic disease that was the main subject of Preston's 1994 #1 bestseller, The Hot Zone. What we really should be worrying about, explains Preston in this terrifying, cautionary new title, is smallpox, or variola. But wasn't that eradicated? many might ask, particularly older Americans who remember painful vaccinations and the resultant scars. Officially, yes, nods Preston, who devotes the first half of the book to the valorous attempt by an army of volunteers to wipe out the virus (an attempt initially sparked by '60s icon Ram Dass and his Indian guru) via strategic vaccination; in 1977 the last case of naturally occurring smallpox was documented in Somalia, and today the variola virus exists officially in only two storage depots, in Russia and at the Centers for Disease Control in Atlanta (in the freezer of the title). To believe that variola is not held elsewhere, however, is nonsense, argues Preston, who delves into the possibility that several nations, including Iraq and Russia, have recently worked or are currently working with smallpox as a biological weapon. The author devotes much space to the anthrax attacks of last fall, mostly to demonstrate how easily a devastating assault with smallpox could occur here. He includes an interview with Steven Hatfill, who has received much press coverage for the FBI's investigation of him regarding those attacks; his description of meeting Hatfill, hallmarked by a quick character sketch ("He was a vital, engaging man, with a sharp mind and a sense of humor.... He was heavy-set but looked fit, and he had dark blue eyes") is emblematic of what makes this New Yorker regular's writing so gripping. Preston humanizes his science reportage by focusing on individuals-scientists, patients, physicians, government figures. That, and a flair for teasing out without overstatement the drama in his inherently compelling topics, plus a prose style that's simple and forceful, make this book as exciting as the best thrillers, yet scarier by far, for Preston's pages deal with clear, present and very real dangers. Copyright 2002 Cahners Business Information.
Library Journal
In an account that might well be called Return of the Hot Zone, Preston sends out alarms that smallpox could reenter our midst and what's worse, in genetically engineered form. Copyright 2002 Cahners Business Information.
School Library Journal
Adult/High School-This book about smallpox begins with the anthrax attacks of October, 2001, and, by the end of this thriller, Preston has chillingly linked the two topics. All of the anthrax evidence from the Hart Senate Office Building was taken to the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) in Fort Detrick, MD, and it is here that the author first brings smallpox into consideration by introducing Peter Jahrling, the organization's senior scientist. He believes that smallpox, which has killed more people than any other infectious disease, is the greatest biological threat facing humanity. Preston relates the history of smallpox from 1000 B.C. to the outbreaks in the 1970s. He goes into great detail about the World Health Organization's campaign to eradicate it and the lost opportunity to destroy it forever. His final chapter introduces the idea of genetically modified smallpox that might be resistant not only to vaccines, but also to acquired immunity. The author draws readers into his narrative by humanizing his facts; researchers, WHO workers, and smallpox victims relay parts of this vivid and alarming story. Fans of Preston's The Hot Zone (Anchor, 1995) will definitely want to read this work for that subtle blend of information and horror that he is so adept at providing.-Jody Sharp, Harford County Public Library, MD Copyright 2003 Cahners Business Information.
Kirkus Reviews
Preston guides us deftly on another scary excursion (Hot Zone, 1994) into the world of really bad viruses—this time smallpox, with a side helping of anthrax. The author’s steady, ominous voice gives the world of smallpox a particular grimness: Epidemiologists consider it the worst human disease on record, having killed perhaps a billion people over the last 100 years. The scourge went to the brink of extinction, having been targeted for erasure from the natural world through a comprehensive eradication program ("No greater deed was ever done in medicine, and no better thing ever came from the human spirit," declares Preston). Since the disease had last been seen in nature in 1979, during the Cold War, it was decided that samples of the various strains would be kept in both the US and in the USSR. After that, it wasn’t long before the black absurdity of an even greater menace was conjured up by its specter as a bio-weapon—manipulable and dreadful. Preston takes readers through the eradication program, describing in clipped detail smallpox’s effects. He outlines the potential of the virus as a biological weapon and explains why it is thought that Russia developed and deployed missiles outfitted with smallpox-laden warheads in the 1990s (he doesn’t conjecture what the US may have been doing, if anything, along such lines during the same period) and suggests that anyone who believes that smallpox samples are held only by Russia and the US is living in a fool’s paradise. Those doing research on smallpox—proposals to destroy the last known strains ran into bioethical conflicts—are the same as those detailed to handle the anthrax letters, and Preston takes up that lattersubject before moving on to a discussion of super-lethal, vaccine-resistant, antiviral weapons. Nowhere to run, nowhere to hide from microscopic infectious agents? Welcome to Mr. Preston’s frightening neighborhood.
From the Publisher
Advance praise for The Demon in the Freezer

“Richard Preston has brought us another book that reads like a top-notch thriller. Would that it were fiction. As the movie unfolds in your mind, remember this: It can happen here.”
-Laurie Garrett, author of The Coming Plague

The Demon in the Freezer is fascinating, frightening, and important. It reads like a thriller, but the demons are real. Richard Preston has a ‘black patent’ on this kind of reporting and storytelling. He is the only writer on the scene who can make the inside story of biological weapons so darkly entertaining.
Read this book and pray that its heroes can lock the demon back in the freezer.”
-Jonathan Weiner, author of The Beak of the Finch

Praise for The Hot Zone

“One of the most horrifying things I’ve ever read in my whole life. What a remarkable piece of work. I devoured it in two or three sittings, and have a feeling the memories will linger a long time.”
-Stephen King

“A tour de force . . . Preston uses the power of simple narrative to drive deep his story’s urgent truths.”
-Los Angeles Times Book Review

“Utterly engrossing . . . Will make your blood curdle.”
-The Washington Post Book World

From the Hardcover edition.

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Product Details

  • ISBN-13: 9781588362452
  • Publisher: Random House Publishing Group
  • Publication date: 10/8/2002
  • Sold by: Random House
  • Format: eBook
  • Sales rank: 32,922
  • File size: 444 KB

Meet the Author

Richard Preston
Richard Preston is the author of The Hot Zone, a #1 New York Times bestseller, and of The Cobra Event, a bioterror thriller, also a New York Times bestseller. A writer for The New Yorker since 1985, Preston won the American Institute of Physics award and is the only nondoctor ever to have received the CDC’s Champion of Prevention award. He has an asteroid named after him and lives outside of New York City.

From the Hardcover edition.

Biography

Richard Preston is a versatile and unique writer. He's penned nonfiction and fiction, both to popular and critical acclaim. A frequent contributor to The New Yorker, he's written books about the vast intricacies and limitlessness of outer space; about microscopic, infinitely complex and deadly viruses; and—well before September 11—about the all-too-real threat of biological terrorism.

Preston is best known for creating a media frenzy and subsequent shockwave of terror in 1994 with his critically acclaimed, No. 1 New York Times bestseller, The Hot Zone. In a gripping, narrative style, The Hot Zone, relates a gripping true tale: In late 1989 in the suburbs of Washington, D.C., strands of the Ebola virus were found in the carcass of recently imported monkey from Africa. The book recounts the heroic efforts of soldiers and scientists as they attempted to avert a deadly outbreak of the virus, which is highly contagious and reputedly kills 90 percent of those it infects. Stephen King called it "one of the most horrifying things I've ever read."

The Hot Zone succeeded, not solely because the story was infectiously compelling and masterfully told, but because it was chilling to the bone. People were genuinely frightened. Everyone wanted to know, "Can this actually happen?" and "Are we really prepared if it does?"

Preston's next project, The Cobra Event, still has readers asking these same questions. The amazing achievement here: It's a work of fiction. About a biological terror attack on New York City, the plausibility of such a scenario is now, in our post-9/11 world, even more believable and scary. In fact, when then-President Bill Clinton read The Cobra Event, he was horrified. The New York Times reported: "Mr. Clinton was so alarmed by The Cobra Event that he instructed intelligence experts to evaluate its credibility." Preston recalled in a magazine interview: "So I get this frantic series of calls on my answering machine; 'Newt Gingrich is trying to reach you. He's been instructed by the President to call you and get your advice.' So I think, right, sure. But I end up talking with Gingrich for quite some time about biological terrorism." Preston has since appeared before the Senate Judiciary Subcommittee on Technology, Terrorism & Government Information and the Senate Select Committee on Intelligence on Chemical and Biological Weapons Threats to America.

Of The Cobra Event,Newsweek wrote, "…Preston has inadvertently created a new hybrid of fact and fiction…" Inadvertent or not, Preston's almost indistinguishable blending of fact and fiction makes for a great read. Like his nonfiction, the characters are highly developed and the pacing is swift. And the fear factor: intense long after the last page is read.

Like fellow nonfiction writers Mark Bowden (Black Hawk Down) and Jon Krakauer (Into Thin Air) and novelist Michael Crichton (Jurassic Park, Timeline, etc.), Preston has perfected the art of character. Science provides the backdrop to his work, but it never gets in the way of the story. After all, he's not a scientist. "I'm a writer, pure and simple," Preston once said. "I write about people."

Good To Know

An asteroid is named after Richard Preston. Called Asteroid Preston, it is approximately 3-5 miles across, and could actually collide with Mars—or Earth!—in approximately 100,00 years.

The Hot Zone inspired the 1995 hit movie Outbreak, which attracted an all-star cast led by Dustin Hoffman, Rene Russo, Morgan Freeman, Kevin Spacey, Cuba Gooding, Jr., and Donald Sutherland. The actual film version of Preston's book never got made; it stalled, and the competing project that became Outbreak was the one that made it to theaters.

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    1. Hometown:
      Hopewell, New Jersey
    1. Date of Birth:
      August 5, 1954
    2. Place of Birth:
      Cambridge, Massachusetts
    1. Education:
      B.A., Pomona College, 1976; Ph.D. in English, Princeton University, 1983
    2. Website:

Read an Excerpt

Chapter 1
Something in the Air Journey Inward

OCTOBER 2-6, 2001

In the early nineteen seventies, a British photo retoucher named Robert Stevens arrived in south Florida to take a job at the National Enquirer, which is published in Palm Beach County. At the time, photo retouchers for supermarket tabloids used an airbrush (nowadays they use computers) to clarify news photographs of world leaders shaking hands with aliens or to give more punch to pictures of six-month-old babies who weigh three hundred pounds. Stevens was reputed to be one of the best photo retouchers in the business. The Enquirer was moving away from stories like "I Ate My Mother-in-Law's Head," and the editors recruited him to bring some class to the paper. They offered him much more than he made working for tabloids in Britain.

Stevens was in his early thirties when he moved to Florida. He bought a red Chevy pickup truck, and he put a CB radio in it and pasted an American-flag decal in the back window and installed a gun rack next to the flag. He didn't own a gun: the gun rack was for his fishing rods. Stevens spent a lot of time at lakes and canals around south Florida, where he would spin-cast for bass and panfish. He often stopped to drop a line in the water on his way to and from work. He became an American citizen. He would drink a Guinness or two in bars with his friends and explain the Constitution to them. "Bobby was the only English redneck I ever knew," Tom Wilbur, one of his best friends, said to me.

Stevens's best work tended to get the Enquirer sued. When the TV star Freddie Prinze shot himself to death, Stevens joined two photographs into a seamless image of Prinze and Raquel Welch at a party together. The implication was that they had been lovers, and this sparked a lawsuit. He enhanced a photograph of a woman with a long neck: "Giraffe Woman." Giraffe Woman sued. His most famous retouching job was on a photograph of Elvis lying dead in his coffin, which ran on the cover of the Enquirer. Elvis's bloated face looked a lot better in Stevens's version than it did in the handiwork of the mortician.

Robert Stevens was a kindhearted man. He filed the barbs off his fishing hooks so that he could release a lot of the fish he caught, and he took care of feral cats that lived in the swamps around his house. There was something boyish about him. Even when he was in his sixties, children in the neighborhood would knock on the door and ask his wife, Maureen, "Can Bobby come out and play?" Not long before he died, he began working for The Sun, a tabloid published by American Media, the company that also owns the National Enquirer. The two tabloids shared space in an office building in Boca Raton.

on thursday, September 27th, Robert Stevens and his wife drove to Charlotte, North Carolina, to visit their daughter Casey. They hiked at Chimney Rock Park, where each autumn brings the spectacular sight of five hundred or more migrating hawks soaring in the air at once, and Maureen took a photograph of her husband with the mountains behind him. By Sunday, Stevens was not feeling well. They left for Florida Sunday night, and he got sick to his stomach during the drive home. On Monday, he began running a high fever and became incoherent. At two o'clock on Tuesday morning, Maureen took him to the emergency room of the John F. Kennedy Medical Center in Palm Beach County. A doctor there thought he might have meningitis. Five hours later, Stevens started having convulsions.

The doctors performed a spinal tap on him, and the fluid came out cloudy. Dr. Larry Bush, an infectious-disease specialist, looked at slides of the fluid and saw that it was full of rod-shaped bacteria with flat ends, a little like slender macaroni. The bacteria were colored blue with Gram stain-they were Gram-positive. Dr. Bush thought, anthrax. Anthrax, or Bacillus anthracis, is a single-celled bacterial micro-organism that forms spores, and it grows explosively in lymph and blood. By Thursday, October 4th, a state lab had confirmed the diagnosis. Stevens's symptoms were consistent with inhalation anthrax, which is caused when a person breathes in the spores. The disease is extremely rare. There had been only eighteen cases of inhalation anthrax in the past hundred years in the United States, and the last reported case had been twenty-three years earlier. The fact that anthrax popped into Dr. Bush's mind had not a little to do with recent news reports about two of the September 11th hijackers casing airports around south Florida and inquiring about renting crop-dusting aircraft. Anthrax could be distributed from a small airplane.

Stevens went into a coma, and at around four o'clock in the afternoon of Friday, October 5th, he suffered a fatal breathing arrest. Minutes later, one of his doctors made a telephone call to the Federal Centers for Disease Control and Prevention-the CDC-in Atlanta, and spoke with Dr. Sherif Zaki, the chief of infectious-diseases pathology.

Sherif Zaki inhabits a tiny office on the second floor of Building 1 at the CDC. The hallway is made of white cinder block, and the floor is linoleum. The buildings of the CDC sit jammed together and joined by walkways on a tight little campus in a green and hilly neighborhood in northeast Atlanta. Building 1 is a brick oblong with aluminum-framed windows. It was built in the nineteen fifties, and the windows look as if they haven't been cleaned since then.

Sherif Zaki is a shy, quiet man in his late forties, with a gentle demeanor, a slight stoop in his posture, a round face, and pale green eyes distinguished by dazzling pupils, which give him a piercing gaze. He speaks precisely, in a low voice. Zaki went out into the hallway, where his pathology group often gathered to talk about ongoing cases. "Mr. Stevens has passed away," he said.

"Who's going to do the post?" someone asked. A post is a postmortem exam, an autopsy.

Zaki and his team were going to do the post.

early the next morning, on Saturday, October 6th, Sherif Zaki and his team of CDC pathologists arrived in West Palm Beach in a chartered jet, and a van took them to the Palm Beach County medical examiner's office, which takes up two modern, one-story buildings set under palm trees on a stretch of industrial land near the airport. They went straight to the autopsy suite, carrying bags of tools and gear. The autopsy suite is a large, open room in the center of one of the buildings. Two autopsies were in progress. Palm Beach medical examiners were bending over opened bodies on tables, and there was an odor of fecal matter in the air, which is the normal smell of an autopsy. The examiners stopped work when the CDC people entered.

"We're here to assist you," Zaki said in his quiet way.

The examiners were polite and helpful but did not make eye contact, and Zaki sensed that they were afraid. Stevens's body contained anthrax cells, although he had not been dead long enough for the cells to become large numbers of spores. In any case, any spores in his body were wet, and wet anthrax spores are nowhere near as dangerous as dry spores, which can float in the air like dandelion seeds, looking for fertile ground.

The CDC people opened a door in the morgue refrigerator and pulled out a tray. The body had been zipped up inside a Tyvek body bag. Without opening the bag, they lifted the body up by the shoulders and feet and placed it on a bare metal gurney. They rolled the gurney into a supply room and closed the door behind them. They would do the autopsy on the gurney in a closed room, to prevent the autopsy tables from being contaminated with spores.

The chief medical examiner of Palm Beach County, Dr. Lisa Flannagan, was going to do the primary incisions, while Zaki and his people would do the organ exams. Flannagan is a slender, self-assured woman, with a reputation as a top-notch examiner. Everybody gowned up, and they put on N-100 biohazard masks, clear plastic face shields, hair covers, rubber boots, and three layers of gloves. The middle glove was reinforced with Kevlar. Then they unzipped the bag.

The CDC team lifted the body up, gripping it beneath the shoulders and legs, and someone snatched the bag out from underneath it. They lowered the body back onto the bare metal deck of the gurney. Stevens had been a pleasant-looking man with a cheerful appearance. He was a bluish color now, and his eyes were half open.

Heraclitus said that when a man dies, a world passes away. The terribly human look on the face of the deceased man disturbed Sherif Zaki. It was so hard to picture this man in life and then to connect that picture with the body on the gurney. This was the toughest thing for a prosector, and you never got over it, really. Zaki did not want to connect the living man with the body. You had to put it aside, and you could not think about it. His duty now was to identify the exact type of disease that Stevens had, to learn if he had inhaled spores or perhaps had become infected some other way. This might help save lives. Yet cutting into an unfathomed body was difficult, and after a hard post, Sherif Zaki would not feel like himself for a week afterward. "It's not an uplifting process," Zaki said to me.

The team rolled Stevens onto his side and inspected his back under bright lights for signs of cutaneous anthrax-skin anthrax. They didn't find any, and they laid him back down.

Dr. Flannagan took up a scalpel and pressed the tip of the blade on the upper left part of the chest under the shoulder. She made a curving incision that went underneath the nipples, across the chest, and up to the opposite shoulder. Then, starting at the top of the sternum, she made a straight incision down to the solar plexus. This made a cut that looked like a Y, but with a curved top. She finished it with a short horizontal cut across the solar plexus. The opening incision looked rather like the profile of a wineglass.

Dr. Flannagan grasped the skin of the chest, and pulled it upward, peeling it off. She laid the blanket of skin around the neck. She pulled the skin away from the sides of the chest, revealing the ribs and sternum. She took up a pair of gardening shears and cut the ribs one by one, snipping them in a wide circle around the sternum. This was to free the chest plate, the front of the rib cage. When she had finished cutting the ribs, she pushed her fingertips underneath the chest plate and pried it upward, as if she were raising a lid from a box.

As Flannagan lifted the chest plate, a gush of bloody fluid poured out from under the ribs and ran down over the body and poured over the gurney and onto the floor.

The chest cavity was engorged with bloody liquid. No one in the room had ever done a post on a person who had died of anthrax. Zaki had studied photographs of autopsies that had been done on anthrax victims in the Soviet Union, in the spring of 1979, after a plume of finely ground anthrax dust had come out of a bioweapons manufacturing facility in Sverdlovsk (Yekaterinburg) and had killed at least sixty-six people downwind, but the photographs had not prepared him for the sight of the liquid that was pouring out of this man's chest. They were going to have quite a time cleaning up the room. The bloody liquid was saturated with anthrax cells, and the cells would quickly start turning into spores when they hit the air.

Dr. Flannagan stood back. It was the turn of the CDC team.

The CDC people wanted to look at the lymph nodes in the center of the chest. Working gently with his fingertips, Zaki separated the lungs and pulled them to either side, revealing the heart. The heart and lungs were drowned in red liquid. He couldn't see anything. Someone brought a ladle, and they started spooning the liquid from the chest. They poured it off into containers, and ultimately they had ladled out almost a gallon of it.

Zaki worked his way slowly down into the chest. Using a scalpel, he removed the heart and parts of the lungs, which revealed the lymph nodes of the chest, just below the fork of the bronchial tubes. The lymph nodes of a healthy person are pale nodules the size of peas. Stevens's lymph nodes were the size of plums, and they looked exactly like plums-they were large, shiny, and dark purple, verging on black. Zaki cut into a plum with his scalpel. It disintegrated at the touch of the blade, revealing a bloody interior, saturated with hemorrhage. This showed that the spores that had killed Stevens had gotten into his lungs through the air.

When they had finished the autopsy, the pathologists gathered up their tools and placed some of them inside the body cavity. The scalpels, the gardening shears, scissors, knives, the ladle-the prosection tools were now contaminated with anthrax. The team felt that the safest thing to do with them would be to destroy them. They packed the body cavity with absorbent batting, stuffing it in around the tools, and placed the body inside fresh double body bags. Then, using brushes and hand-pump sprayers filled with chemicals, they spent hours decontaminating the supply room, the bags, the gurney, the floor-everything that had come into contact with fluids from the autopsy. Robert Stevens was cremated. Sherif Zaki later recalled that when he was ladling the red liquid from Stevens's chest, the word murder never entered his mind.

From the Hardcover edition.

Read More Show Less

First Chapter

Chapter 1
Something in the Air Journey Inward

OCTOBER 2-6, 2001

In the early nineteen seventies, a British photo retoucher named Robert Stevens arrived in south Florida to take a job at the National Enquirer, which is published in Palm Beach County. At the time, photo retouchers for supermarket tabloids used an airbrush (nowadays they use computers) to clarify news photographs of world leaders shaking hands with aliens or to give more punch to pictures of six-month-old babies who weigh three hundred pounds. Stevens was reputed to be one of the best photo retouchers in the business. The Enquirer was moving away from stories like "I Ate My Mother-in-Law's Head," and the editors recruited him to bring some class to the paper. They offered him much more than he made working for tabloids in Britain.

Stevens was in his early thirties when he moved to Florida. He bought a red Chevy pickup truck, and he put a CB radio in it and pasted an American-flag decal in the back window and installed a gun rack next to the flag. He didn't own a gun: the gun rack was for his fishing rods. Stevens spent a lot of time at lakes and canals around south Florida, where he would spin-cast for bass and panfish. He often stopped to drop a line in the water on his way to and from work. He became an American citizen. He would drink a Guinness or two in bars with his friends and explain the Constitution to them. "Bobby was the only English redneck I ever knew," Tom Wilbur, one of his best friends, said to me.

Stevens's best work tended to get the Enquirer sued. When the TV star Freddie Prinze shot himself to death, Stevens joined two photographs into aseamless image of Prinze and Raquel Welch at a party together. The implication was that they had been lovers, and this sparked a lawsuit. He enhanced a photograph of a woman with a long neck: "Giraffe Woman." Giraffe Woman sued. His most famous retouching job was on a photograph of Elvis lying dead in his coffin, which ran on the cover of the Enquirer. Elvis's bloated face looked a lot better in Stevens's version than it did in the handiwork of the mortician.

Robert Stevens was a kindhearted man. He filed the barbs off his fishing hooks so that he could release a lot of the fish he caught, and he took care of feral cats that lived in the swamps around his house. There was something boyish about him. Even when he was in his sixties, children in the neighborhood would knock on the door and ask his wife, Maureen, "Can Bobby come out and play?" Not long before he died, he began working for The Sun, a tabloid published by American Media, the company that also owns the National Enquirer. The two tabloids shared space in an office building in Boca Raton.

on thursday, September 27th, Robert Stevens and his wife drove to Charlotte, North Carolina, to visit their daughter Casey. They hiked at Chimney Rock Park, where each autumn brings the spectacular sight of five hundred or more migrating hawks soaring in the air at once, and Maureen took a photograph of her husband with the mountains behind him. By Sunday, Stevens was not feeling well. They left for Florida Sunday night, and he got sick to his stomach during the drive home. On Monday, he began running a high fever and became incoherent. At two o'clock on Tuesday morning, Maureen took him to the emergency room of the John F. Kennedy Medical Center in Palm Beach County. A doctor there thought he might have meningitis. Five hours later, Stevens started having convulsions.

The doctors performed a spinal tap on him, and the fluid came out cloudy. Dr. Larry Bush, an infectious-disease specialist, looked at slides of the fluid and saw that it was full of rod-shaped bacteria with flat ends, a little like slender macaroni. The bacteria were colored blue with Gram stain-they were Gram-positive. Dr. Bush thought, anthrax. Anthrax, or Bacillus anthracis, is a single-celled bacterial micro-organism that forms spores, and it grows explosively in lymph and blood. By Thursday, October 4th, a state lab had confirmed the diagnosis. Stevens's symptoms were consistent with inhalation anthrax, which is caused when a person breathes in the spores. The disease is extremely rare. There had been only eighteen cases of inhalation anthrax in the past hundred years in the United States, and the last reported case had been twenty-three years earlier. The fact that anthrax popped into Dr. Bush's mind had not a little to do with recent news reports about two of the September 11th hijackers casing airports around south Florida and inquiring about renting crop-dusting aircraft. Anthrax could be distributed from a small airplane.

Stevens went into a coma, and at around four o'clock in the afternoon of Friday, October 5th, he suffered a fatal breathing arrest. Minutes later, one of his doctors made a telephone call to the Federal Centers for Disease Control and Prevention-the CDC-in Atlanta, and spoke with Dr. Sherif Zaki, the chief of infectious-diseases pathology.

Sherif Zaki inhabits a tiny office on the second floor of Building 1 at the CDC. The hallway is made of white cinder block, and the floor is linoleum. The buildings of the CDC sit jammed together and joined by walkways on a tight little campus in a green and hilly neighborhood in northeast Atlanta. Building 1 is a brick oblong with aluminum-framed windows. It was built in the nineteen fifties, and the windows look as if they haven't been cleaned since then.

Sherif Zaki is a shy, quiet man in his late forties, with a gentle demeanor, a slight stoop in his posture, a round face, and pale green eyes distinguished by dazzling pupils, which give him a piercing gaze. He speaks precisely, in a low voice. Zaki went out into the hallway, where his pathology group often gathered to talk about ongoing cases. "Mr. Stevens has passed away," he said.

"Who's going to do the post?" someone asked. A post is a postmortem exam, an autopsy.

Zaki and his team were going to do the post.

early the next morning, on Saturday, October 6th, Sherif Zaki and his team of CDC pathologists arrived in West Palm Beach in a chartered jet, and a van took them to the Palm Beach County medical examiner's office, which takes up two modern, one-story buildings set under palm trees on a stretch of industrial land near the airport. They went straight to the autopsy suite, carrying bags of tools and gear. The autopsy suite is a large, open room in the center of one of the buildings. Two autopsies were in progress. Palm Beach medical examiners were bending over opened bodies on tables, and there was an odor of fecal matter in the air, which is the normal smell of an autopsy. The examiners stopped work when the CDC people entered.

"We're here to assist you," Zaki said in his quiet way.

The examiners were polite and helpful but did not make eye contact, and Zaki sensed that they were afraid. Stevens's body contained anthrax cells, although he had not been dead long enough for the cells to become large numbers of spores. In any case, any spores in his body were wet, and wet anthrax spores are nowhere near as dangerous as dry spores, which can float in the air like dandelion seeds, looking for fertile ground.

The CDC people opened a door in the morgue refrigerator and pulled out a tray. The body had been zipped up inside a Tyvek body bag. Without opening the bag, they lifted the body up by the shoulders and feet and placed it on a bare metal gurney. They rolled the gurney into a supply room and closed the door behind them. They would do the autopsy on the gurney in a closed room, to prevent the autopsy tables from being contaminated with spores.

The chief medical examiner of Palm Beach County, Dr. Lisa Flannagan, was going to do the primary incisions, while Zaki and his people would do the organ exams. Flannagan is a slender, self-assured woman, with a reputation as a top-notch examiner. Everybody gowned up, and they put on N-100 biohazard masks, clear plastic face shields, hair covers, rubber boots, and three layers of gloves. The middle glove was reinforced with Kevlar. Then they unzipped the bag.

The CDC team lifted the body up, gripping it beneath the shoulders and legs, and someone snatched the bag out from underneath it. They lowered the body back onto the bare metal deck of the gurney. Stevens had been a pleasant-looking man with a cheerful appearance. He was a bluish color now, and his eyes were half open.

Heraclitus said that when a man dies, a world passes away. The terribly human look on the face of the deceased man disturbed Sherif Zaki. It was so hard to picture this man in life and then to connect that picture with the body on the gurney. This was the toughest thing for a prosector, and you never got over it, really. Zaki did not want to connect the living man with the body. You had to put it aside, and you could not think about it. His duty now was to identify the exact type of disease that Stevens had, to learn if he had inhaled spores or perhaps had become infected some other way. This might help save lives. Yet cutting into an unfathomed body was difficult, and after a hard post, Sherif Zaki would not feel like himself for a week afterward. "It's not an uplifting process," Zaki said to me.

The team rolled Stevens onto his side and inspected his back under bright lights for signs of cutaneous anthrax-skin anthrax. They didn't find any, and they laid him back down.

Dr. Flannagan took up a scalpel and pressed the tip of the blade on the upper left part of the chest under the shoulder. She made a curving incision that went underneath the nipples, across the chest, and up to the opposite shoulder. Then, starting at the top of the sternum, she made a straight incision down to the solar plexus. This made a cut that looked like a Y, but with a curved top. She finished it with a short horizontal cut across the solar plexus. The opening incision looked rather like the profile of a wineglass.

Dr. Flannagan grasped the skin of the chest, and pulled it upward, peeling it off. She laid the blanket of skin around the neck. She pulled the skin away from the sides of the chest, revealing the ribs and sternum. She took up a pair of gardening shears and cut the ribs one by one, snipping them in a wide circle around the sternum. This was to free the chest plate, the front of the rib cage. When she had finished cutting the ribs, she pushed her fingertips underneath the chest plate and pried it upward, as if she were raising a lid from a box.

As Flannagan lifted the chest plate, a gush of bloody fluid poured out from under the ribs and ran down over the body and poured over the gurney and onto the floor.

The chest cavity was engorged with bloody liquid. No one in the room had ever done a post on a person who had died of anthrax. Zaki had studied photographs of autopsies that had been done on anthrax victims in the Soviet Union, in the spring of 1979, after a plume of finely ground anthrax dust had come out of a bioweapons manufacturing facility in Sverdlovsk (Yekaterinburg) and had killed at least sixty-six people downwind, but the photographs had not prepared him for the sight of the liquid that was pouring out of this man's chest. They were going to have quite a time cleaning up the room. The bloody liquid was saturated with anthrax cells, and the cells would quickly start turning into spores when they hit the air.

Dr. Flannagan stood back. It was the turn of the CDC team.

The CDC people wanted to look at the lymph nodes in the center of the chest. Working gently with his fingertips, Zaki separated the lungs and pulled them to either side, revealing the heart. The heart and lungs were drowned in red liquid. He couldn't see anything. Someone brought a ladle, and they started spooning the liquid from the chest. They poured it off into containers, and ultimately they had ladled out almost a gallon of it.

Zaki worked his way slowly down into the chest. Using a scalpel, he removed the heart and parts of the lungs, which revealed the lymph nodes of the chest, just below the fork of the bronchial tubes. The lymph nodes of a healthy person are pale nodules the size of peas. Stevens's lymph nodes were the size of plums, and they looked exactly like plums-they were large, shiny, and dark purple, verging on black. Zaki cut into a plum with his scalpel. It disintegrated at the touch of the blade, revealing a bloody interior, saturated with hemorrhage. This showed that the spores that had killed Stevens had gotten into his lungs through the air.

When they had finished the autopsy, the pathologists gathered up their tools and placed some of them inside the body cavity. The scalpels, the gardening shears, scissors, knives, the ladle-the prosection tools were now contaminated with anthrax. The team felt that the safest thing to do with them would be to destroy them. They packed the body cavity with absorbent batting, stuffing it in around the tools, and placed the body inside fresh double body bags. Then, using brushes and hand-pump sprayers filled with chemicals, they spent hours decontaminating the supply room, the bags, the gurney, the floor-everything that had come into contact with fluids from the autopsy. Robert Stevens was cremated. Sherif Zaki later recalled that when he was ladling the red liquid from Stevens's chest, the word murder never entered his mind.


From the Hardcover edition.

Copyright 2002 by Richard Preston
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Customer Reviews

Average Rating 4.5
( 102 )
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See All Sort by: Showing 1 – 20 of 102 Customer Reviews
  • Anonymous

    Posted March 11, 2007

    Real Demons

    The Demon in the Freezer is a wonderful book. It is so interesting because it is a true story, and smallpox and anthrax are real demons. The way Richard Preston set up the story was easy to follow, but kept it interesting. I enjoyed this novel considerably. It kept me on the edge of my seat the entire time. For anyone who is interested in smallpox, anthrax, or diseases in general, this is a must-read book. If you aren¿t interested in diseases or biological weapons at all, this may not be the best book for you, but I¿d advise you to give it a chance. I think that almost anyone could enjoy this story because smallpox and anthrax are real demons that can affect us in real life.

    4 out of 4 people found this review helpful.

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  • Anonymous

    Posted April 21, 2006

    Excellent!

    Truely terrifying in complextion. It's much like The Hot Zone, but The Hot Zone is another excellent book.

    3 out of 3 people found this review helpful.

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  • Anonymous

    Posted October 22, 2002

    Scarier than "The Shining"

    Better than any fiction thriller! Richard Preston's latest book is written to keep you turning the pages. With his chapters being rather brief in length, you'll have the opportunity to take a deep breath ocasionally. Small pox, killing over one billion people in the last one hundred years is the disease doctors call the most horrific and now I can see why. Richard Preston fleshs out the real people, that are working in hopes of protecting us all, at the CDC & USAMRID facilities. Unfortunately, there is only so much they can do. My family and I will be first in line should the day come when the small pox vacination becomes available again. Get a good nights sleep before you read this book; it'll be a while before you do after you read it.

    2 out of 2 people found this review helpful.

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  • Anonymous

    Posted September 10, 2010

    An very timely book about an eradicated disease

    In 1980 the World Health Organization announced with much fanfare that the disease variola, or smallpox, perhaps the most important disease in terms of historcal events, had been purposefully purged from the face of the earth never to kill or disfigure another human being. They were right and they were so very wrong...

    Richard Preston tells the story of a disease which has been the bane of mankind for thousands of years. A disease so devastating to humanity that it has the distinction of being the only disease eliminated from the human population. Unfortunately, as Preston points, out there are stores of variola left in the world, some of them in controlled labatories for legitimate study but undoubtedly other stores exist for nefarious--read terroistic- purposes.

    Amazingly profound and thought provoking especially in our post 9-11, post smallpox immuninization world.

    A bit on the techincal side and at times repetative but certainly a book that should cause everyone to think about the ramifications should the demon be allowed to thaw.

    1 out of 2 people found this review helpful.

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  • Anonymous

    Posted February 29, 2008

    The threat of nations

    Richard Preston, author of the acclaimed book: 'The Hot Zone', once again delivers an easy-to-read, page-turner on our unseen enemies: viruses. Medical jargon aside or merely minimised for the lay-person, Preston writes with a conviction and is convincing in his prose on the inevitable. One day, we will encounter another threat. It may not be World War III, but rather the threat may come from nature and Darwin's idea of 'survival of the fittest'. The fittest that survive may be the virus. It may be enhanced by a nation's enemy playing 'Frankenstein' with microbial fire in their labs. The potential for another virus 'like the flu or the plague' to unleash a judgement on us is not one of fairytales or science fiction. An outbreak of pandemic proportions is not unrealistic given our easy access to other countries and Richard Preston offers an educational look at what some of these viruses may be, while also making us aware that we are not the strongest of the species, but our existence may very well be temporary.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted November 22, 2002

    Worrisome Truth

    Richard Preston does an excellent job of tracing the demise of smallpox through the dedicated world-wide efforts of many. He then shows how some decisions were made that we might wish could be rethought, given the subsequent events. He also does a good job of putting together the story of the post 9/11 anthrax events in this country. Having read Preston's other biological books, I found this one to be a little bit disjointed, as though it needed one more editing process to knit it all together a bit more cleanly. But I still recommend it hightly for the content.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted October 21, 2002

    Brilliant as always

    Richard Preston does it again with Demon in the Freezer. A true page turner with excitement in every new chapter. As with Hot Zone and Cobra Event Mr. Preston delivers a complex scientific topic to the lay reader and does it superbly. I am anxiously awaiting his next adventure. I just hope it does not take too long. Well Done and a GREAT read!

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted October 3, 2002

    wow!!!!!!!!!!!!!

    wow! one of the bast books ive ever read. I dont read a lot and this was so good i went out and got the other books hes written. wow wow wow wow wow !!!!!

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted October 5, 2013

    Hero

    Hey im back! My nook broke soo im using my sisters im so glad to se you again!!!!!!!!!

    0 out of 1 people found this review helpful.

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  • Anonymous

    Posted September 10, 2013

    Scary!

    Very scary read but informative! Highly recommended!

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  • Anonymous

    Posted August 30, 2013

    Snowheart

    Hey wheres the leader?

    0 out of 1 people found this review helpful.

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  • Anonymous

    Posted August 31, 2013

    Autumnbreeze

    Autumnbreeze nodded. "Sounds good to me! Who'll be leader? Or deputy?"

    0 out of 1 people found this review helpful.

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  • Anonymous

    Posted August 30, 2013

    Willowbreeze

    A shy cat walks gracefuly into the camp she walks up to you and says "may I be deputy?" Suddenly she sees a rabbit nearby and razor quickly she catches the rabbit and brings it back to you while you wonder how she could move so fast with such accercy. "Please may I join as deputy?"

    0 out of 1 people found this review helpful.

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  • Anonymous

    Posted August 30, 2013

    Twokit

    Yeah. Hey guys, do you want to make our own clan together? Like, now?

    0 out of 1 people found this review helpful.

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  • Anonymous

    Posted February 15, 2013

    TeaPotsOn

    Starts out a great read, but it drags on after a few chapters

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  • Anonymous

    Posted January 5, 2013

    Great read for any biology "nerd" interesting info check ot out!

    Great easy read about smallpox and its history.only gave 4 stars because im not done reading it yet. Each chapter reveals new info on the topic from past to present. Stories of people who contracted the disease as well as detailed interesting epidemiology info. Im really loving this book so far!i love all kinds of books. Love stories are great and all but this book takes you back to the real world where real bad things exist

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  • Anonymous

    Posted December 28, 2012

    Anonymous

    Was good but slow at some parts.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted July 21, 2012

    Patchcloud

    *patchcloud lays in a nest*

    0 out of 2 people found this review helpful.

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  • Anonymous

    Posted January 3, 2012

    Demon in the freazer

    Awsome book need to read it armando!

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  • Anonymous

    Posted December 6, 2011

    Pretty good for a school read

    This book was forced on me in AP biology and usually i dont like the books given to us by the school but this is probably one of the better ones. It holds many informative details and it helped a lot when we did our final projects. Worth the read if you need something like th for class. Wouldnt recommend reading this when your board though, it might make you fall asleep.

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