The Design and Analysis of Clinical Experiments / Edition 1

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Overview

This unique reference fills a void in the literature on clinical experimentation by focusing on principles that are especially useful in the design and analysis of studies on human subjects. It shows how to choose between modern and classical competing designs for a clinical study -- such as crossover designs, multicenter studies, and repeated measure experiments -- how to carry out each design and analyze the resulting data. Provides many practical examples, end-of-chapter problems and references, and solutions to each problem. The mathematical bases are given for several design strategies as well as for their analysis. Provides tables of critical values, 200 random permutations of the first one hundred integers, and an appendix on programmable methods for determining sample sizes.
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Editorial Reviews

Booknews
A guide for clinical investigators and biostatisticians in biomedical research centers and the pharmaceutical industry who are responsible for designing clinical experiments and for analyzing resulting data. Real examples from such specialties as cardiology, dentistry, gerontology, neurology, pediatrics, and psychiatry are used to illustrate designs and their analyses. Includes numerical and algebraic chapter problems. Can be used as a text for a second-year, graduate-level course. First published in 1986 by John Wiley & Sons. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

Table of Contents

1 Reliability of Measurement 1
2 Simple Linear Regression Analysis 33
3 The Parallel Groups Design 46
4 Special Cases of the Parallel Groups Study 91
5 Blocking to Control for Prognostic Variables 120
6 Stratification to Control for Prognostic Variables 149
7 Analysis of Covariance and the Study of Change 186
8 Repeated Measurements Studies 220
9 Latin and Greco-Latin Squares 241
10 The Crossover Study 263
11 Balanced Incomplete Block Designs 291
12 Factorial Experiments 306
13 Split-Plot Designs and Confounding 348
App Sample-Size Determination 369
Author Index 419
Subject Index 423
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