Design and Analysis of Clinical Trials: Concept and Methodologies / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $11.99
Usually ships in 1-2 business days
(Save 92%)
Other sellers (Hardcover)
  • All (7) from $11.99   
  • New (3) from $66.47   
  • Used (4) from $11.99   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2008

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.


Ships from: Chicago, IL

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2015

Feedback rating:


Condition: New
Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2015

Feedback rating:


Condition: New
Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Sort by


A unique, unifying treatment for statistics and science in clinical trials

What sets this volume apart from the many books dealing with clinical trials is its integration of statistical and clinical disciplines. Stressing communication between biostatisticians and clinical scientists, this work clearly relates statistical interpretation to clinical issues arising in different stages of pharmaceutical research and development. Plus, the principles presented here are universal enough to be easily adapted in non-biopharmaceutical settings.

Design and Analysis of Clinical Trials tackles concepts and methodologies. It not only covers statistical basics such as uncertainty and bias, design considerations such as patient selection, randomization, and the different types of clinical trials but also deals with various methods of data analysis, group sequential procedures for interim analysis, efficacy data evaluation, analysis of safety data, and more. Throughout, the book:
*Surveys current and emerging clinical issues and newly developed statistical methods
*Presents a critical review of statistical methodologies in various therapeutic areas
*Features case studies from actual clinical trials
*Minimizes the mathematics involved, making the material widely accessible
*Offers each chapter as a self-contained entity
*Includes illustrations to highlight the text

This monumental reference on all facets of clinical trials is important reading for physicians, clinical and medical researchers, pharmaceutical scientists, clinical programmers, biostatisticians, and anyone involved in this burgeoning area of clinical research. It can also be used as a textbook ingraduate-level courses in the field.

Incl. critical review of statistical methodologies; case studies; minimal mathematics; hypotheses testing; controls.

Read More Show Less

Editorial Reviews

Chow (biostatistics and data management, Covance, Inc.; Princeton, NJ) and Liu (statistics, National Cheng-Kung U.; Tainan, Taiwan) offer a balanced overview of the clinical issues and statistical concepts of importance to clinicians, biostatisticians, and other clinical scientists involved in evaluating the safety and efficacy of drug therapies in human subjects. Methodological considerations include: selection of patient and control samples, multicenter trials, adjustment for covariates, and data monitoring. Clinical priorities focus on the regulatory process and requirements, new drug applications, and analysis of adverse events. Includes statistical tables and SAS programs. Annotation c. by Book News, Inc., Portland, Or.
Read More Show Less

Product Details

  • ISBN-13: 9780471134046
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 11/28/1998
  • Series: Wiley Series in Probability and Statistics Series, #342
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 672
  • Product dimensions: 6.58 (w) x 9.56 (h) x 1.52 (d)

Meet the Author

Shein-Chung Chow works in biostatistics and data management for Covance Inc.

Jen-Pei Liu works in biostatistics for the National Health Research Institutes and National Chen-Kung University, Taiwan." 1578701260

Read More Show Less

Table of Contents

1 Introduction 1
2 Basic Statistical Concepts 47
3 Basic Design Consideration 93
4 Randomization and Blinding 121
5 Designs for Clinical Trials 176
6 Classification of Clinical Trials 212
7 Analysis of Continuous Data 259
8 Analysis of Categorical Data 306
9 Censored Data and Interim Analysis 363
10 Sample Size Determination 424
11 Issues in Efficacy Evaluation 483
12 Safety Assessment 535
References 572
Appendix A 599
Appendix B 627
Index 635
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)