Design of Caspase Inhibitors as Potential Clinical Agents

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $51.17
Usually ships in 1-2 business days
(Save 77%)
Other sellers (Hardcover)
  • All (8) from $51.17   
  • New (5) from $179.85   
  • Used (3) from $51.17   


Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future

Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including:

  • Arthritic and neurological disorders
  • Lung disease
  • Hereditary fever syndromes
  • Inflammatory bowel and skin diseases
  • Sepsis
  • Liver fibrosis

Outlines Efforts to Develop Molecule Inhibitors for Caspase Activity Transformation

Under the editorial guidance of authoritative inflammatory disease, small molecule discovery, and apoptosis researchers, the book organizes the wide array of caspase literature into one convenient resource. It also summarizes the relative difficulty of transitioning a caspase small molecule inhibitor from the lab to the clinic and suggests approaches to circumvent this difficulty. Taking a novel, yet core approach to disease treatment, this seminal work sets the stage to combat a slew of debilitating diseases through groundbreaking drug development.

Read More Show Less

Editorial Reviews

From the Publisher
... can be a valuable reference source for scientist and students dealing with the medicinal chemistry and chemical biology aspects of apoptosis, inflammation and related diseases.
—Dr. Enrique Pérez-Payá, Centro de Investigación Príncipe Felipe and CSIC (Spain) in ChemMedChem 2009
Read More Show Less

Product Details

  • ISBN-13: 9781420045406
  • Publisher: Taylor & Francis
  • Publication date: 10/28/2008
  • Series: Enzyme Inhibitors Series
  • Pages: 312
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.90 (d)

Table of Contents

Mammalian Caspase Activation Pathways in Apoptosis and Inflammation, S.E. Logue and S.J. Martin

Role of Caspases in Inflammation-Driven Diseases, K. Kersse, T.V. Berghe, S. Lippens, W. Declercq, and P. Vandenabeele

Role of Caspases in Apoptotic-Driven Indications, T. Matsui

Kinetics and Catalytic Activity of Caspases, K.A. Nalley

Nonpeptide Small Molecule Inhibitors of Caspases, A. V. Ivachtchenko, I. Okun, S.E. Tkachenko, A.S. Kiselyov, Y.A. Ivanenkov, and K.V. Balakin

Identification of Inflammatory Caspase Inhibitors, J.A. Wos and T.P. Demuth Jr.

Identification of Apoptotic Caspase Inhibitors, B.R. Ullman

Discovery of a First-in-Class Apoptotic Caspase Inhibitor Emricasan (PF-03491390/IDN-6556), N.C. Hoglen

Novel Approaches to Caspase Inhibitor Discovery, J.M. Scheer and M.J. Romanowski

Therapeutic Potential for Caspase Inhibitors: Present and Future, H. Eda


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)