Design of Caspase Inhibitors as Potential Clinical Agents

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Overview

Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future

Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including:

  • Arthritic and neurological disorders
  • Lung disease
  • Hereditary fever syndromes
  • Inflammatory bowel and skin diseases
  • Sepsis
  • Liver fibrosis

Outlines Efforts to Develop Molecule Inhibitors for Caspase Activity Transformation

Under the editorial guidance of authoritative inflammatory disease, small molecule discovery, and apoptosis researchers, the book organizes the wide array of caspase literature into one convenient resource. It also summarizes the relative difficulty of transitioning a caspase small molecule inhibitor from the lab to the clinic and suggests approaches to circumvent this difficulty. Taking a novel, yet core approach to disease treatment, this seminal work sets the stage to combat a slew of debilitating diseases through groundbreaking drug development.

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Editorial Reviews

From the Publisher
... can be a valuable reference source for scientist and students dealing with the medicinal chemistry and chemical biology aspects of apoptosis, inflammation and related diseases.
—Dr. Enrique Pérez-Payá, Centro de Investigación Príncipe Felipe and CSIC (Spain) in ChemMedChem 2009
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Product Details

  • ISBN-13: 9781420045406
  • Publisher: CRC Press
  • Publication date: 10/28/2008
  • Series: Enzyme Inhibitors Series
  • Pages: 312
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.90 (d)

Table of Contents

Mammalian Caspase Activation Pathways in Apoptosis and Inflammation, S.E. Logue and S.J. Martin

Role of Caspases in Inflammation-Driven Diseases, K. Kersse, T.V. Berghe, S. Lippens, W. Declercq, and P. Vandenabeele

Role of Caspases in Apoptotic-Driven Indications, T. Matsui

Kinetics and Catalytic Activity of Caspases, K.A. Nalley

Nonpeptide Small Molecule Inhibitors of Caspases, A. V. Ivachtchenko, I. Okun, S.E. Tkachenko, A.S. Kiselyov, Y.A. Ivanenkov, and K.V. Balakin

Identification of Inflammatory Caspase Inhibitors, J.A. Wos and T.P. Demuth Jr.

Identification of Apoptotic Caspase Inhibitors, B.R. Ullman

Discovery of a First-in-Class Apoptotic Caspase Inhibitor Emricasan (PF-03491390/IDN-6556), N.C. Hoglen

Novel Approaches to Caspase Inhibitor Discovery, J.M. Scheer and M.J. Romanowski

Therapeutic Potential for Caspase Inhibitors: Present and Future, H. Eda

Index

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