Design of Enzyme Inhibitors As Drugs

Design of Enzyme Inhibitors As Drugs

by Merton Sandler, H. John Smith
     
 

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A high proportion of drugs currently coming to market exert their action in the body by inhibiting a target enzyme involved in a particular body function or in a bacterium, protozoon, or virus causing an infection. This book extends the previous volume in providing a comprehensive coverage of more recently recognized target enzymes and their known inhibitors and,

Overview

A high proportion of drugs currently coming to market exert their action in the body by inhibiting a target enzyme involved in a particular body function or in a bacterium, protozoon, or virus causing an infection. This book extends the previous volume in providing a comprehensive coverage of more recently recognized target enzymes and their known inhibitors and, within this framework of knowledge, demonstrates how the drug designer uses all available information to develop a specific therapeutic agent. Drug design is an interdisciplinary art; this text illustrates the pathway followed from the initial design concept and synthesis of an inhibitor, through its in vitro and in vivo assessments, to clinical trial — a process involving chemists, biochemists, pharmacologists, and clinicians.

Product Details

ISBN-13:
9780192621344
Publisher:
Oxford University Press, USA
Publication date:
05/28/1994
Pages:
848
Product dimensions:
6.50(w) x 9.50(h) x 2.05(d)

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University of London

University of Wales College of Cardiff

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