Design of Osmotic Controlled Drug Delivery System

Design of Osmotic Controlled Drug Delivery System

by Ambikanandan Misra, Pritam D. Kanagale
     
 

Osmotic systems, one of the oral dosage form utilize the principles of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameters and it is also possible to modulate the release characteristics by optimizing the properties of drug and system. The aim of present research was to design and optimize… See more details below

Overview

Osmotic systems, one of the oral dosage form utilize the principles of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameters and it is also possible to modulate the release characteristics by optimizing the properties of drug and system. The aim of present research was to design and optimize the three novel osmotic drug delivery systems viz. Swellable Porous Osmotic System (SPOP), Monolithic Osmotic Tablet System (MOTS) & Controlled Porosity Osmotic System (CPOP) for water soluble and low water soluble drugs and compare principle and methodology of CR design. Extended release formulations of Venlafaxine HCl and Glipizide were developed based on SPOP technology. Extended release formulations of Metoprolol Tartrate and Nifedipine were developed based on MOTS technology. Extended release formulations of Oxybutynin chloride and Atenolol were developed based on CPOP technology. Based on the present work it is clear that extended release formulations of drugs having different solubility profile can be developed using these technologies. The in-vivo pharmacokinetic study in beagle dog confirmed the same.

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Product Details

ISBN-13:
9783838392271
Publisher:
AV Akademikerverlag GmbH & Co. KG.
Publication date:
08/26/2010
Pages:
232
Product dimensions:
6.00(w) x 9.00(h) x 0.53(d)

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