Designing Clinical Research: An Epidemiologic Approach

Designing Clinical Research: An Epidemiologic Approach

by Stephen B. Hulley, Steven R. Cummings, Steven R. Cummings
     
 

ISBN-10: 0683042491

ISBN-13: 9780683042498

Pub. Date: 01/28/1988

Publisher: Lippincott Williams & Wilkins

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for

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Overview

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop.

Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Product Details

ISBN-13:
9780683042498
Publisher:
Lippincott Williams & Wilkins
Publication date:
01/28/1988
Edition description:
Older Edition
Pages:
247
Product dimensions:
7.02(w) x 9.89(h) x 0.57(d)

Table of Contents

Introduction
Acknowledgments
1Getting Started: The Anatomy and Physiology of Clinical Research3
2Conceiving the Research Question17
3Choosing the Study Subjects: Specification, Sampling, and Recruitment25
4Planning the Measurements: Precision and Accuracy37
5Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles51
6Estimating Sample Size and Power: The Nitty-gritty65
7Designing an Observational Study: Cohort Studies95
8Designing an Observational Study: Cross-sectional and Case-control Studies107
9Enhancing Causal Inference in Observational Studies125
10Designing an Experiment: Clinical Trials I143
11Designing an Experiment: Clinical Trials II157
12Designing Studies of Medical Tests175
13Research Using Existing Data: Secondary Data Analysis, Ancillary Studies, and Systematic Reviews195
14Addressing Ethical Issues215
15Designing Questionnaires and Data Collection Instruments231
16Data Management247
17Implementing the Study: Pretesting, Quality Control, and Protocol Revisions259
18Community and International Studies275
19Writing and Funding a Research Proposal285
Answers to Chapter Exercises301
Subject Index319

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