Designing Clinical Research: An Epidemiologic Approach

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Overview

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop.

Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Designing Clinical Research has set the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy to read, uncomplicated presentation. Updated chapters incorporate current research methodology, with an updated syllabus for conducting a clinical research workshop. A Brandon-Hill recommended title.

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Editorial Reviews

Booknews
A text on planning and implementing clinical research, for beginning investigators. Section I examines basic ingredients of research, such as selection of study subjects, hypotheses, and estimating sample sizes. Section II presents design options, covering cohort, cross- sectional, case-control and diagnostic test studies, clinical trials, and confounding. Section III looks at additional skills in ethics, data management, and community and international studies. Emphasis is on common sense as the main ingredient of good science. This edition contains new chapters on medical test studies and secondary data. Hulley is affiliated with the University of California-San Francisco. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780683042498
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 1/28/1988
  • Edition description: Older Edition
  • Pages: 247
  • Product dimensions: 7.02 (w) x 9.89 (h) x 0.57 (d)

Table of Contents

Introduction
Acknowledgments
1 Getting Started: The Anatomy and Physiology of Clinical Research 3
2 Conceiving the Research Question 17
3 Choosing the Study Subjects: Specification, Sampling, and Recruitment 25
4 Planning the Measurements: Precision and Accuracy 37
5 Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles 51
6 Estimating Sample Size and Power: The Nitty-gritty 65
7 Designing an Observational Study: Cohort Studies 95
8 Designing an Observational Study: Cross-sectional and Case-control Studies 107
9 Enhancing Causal Inference in Observational Studies 125
10 Designing an Experiment: Clinical Trials I 143
11 Designing an Experiment: Clinical Trials II 157
12 Designing Studies of Medical Tests 175
13 Research Using Existing Data: Secondary Data Analysis, Ancillary Studies, and Systematic Reviews 195
14 Addressing Ethical Issues 215
15 Designing Questionnaires and Data Collection Instruments 231
16 Data Management 247
17 Implementing the Study: Pretesting, Quality Control, and Protocol Revisions 259
18 Community and International Studies 275
19 Writing and Funding a Research Proposal 285
Answers to Chapter Exercises 301
Subject Index 319
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