Development and Clinical Uses of Haemophilus B Conjugate Vaccines

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"Emphasizing the use of Haemophilus influenzae type b (Hib) conjugate vaccines in clinical practice, this unique and definitive reference covers all important facets of Hib conjugate vaccines, including their historical development, testing, production, quality control, and possible future improvements presenting a valuable paradigm for the generation of other types of conjugate vaccines. Describes vaccine development procedures in detail focusing on the kinds of information used by the Food and Drug Administration to determine whether a ...

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Overview

"Emphasizing the use of Haemophilus influenzae type b (Hib) conjugate vaccines in clinical practice, this unique and definitive reference covers all important facets of Hib conjugate vaccines, including their historical development, testing, production, quality control, and possible future improvements presenting a valuable paradigm for the generation of other types of conjugate vaccines. Describes vaccine development procedures in detail focusing on the kinds of information used by the Food and Drug Administration to determine whether a conjugate vaccine is relatively safe and effective!"

This book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Anne H. Rowley, MD (Loyola University Medical Center)
Description: This volume of the Infectious Disease and Therapy series focuses on the development of the Haemophilus influenzae type b vaccines and their clinical efficacy trials. The information is of great historic interest, because the vaccines have dramatically reduced Haemophilus influenza type b disease and nasopharyngeal colonization and have thus significantly affected the practice of pediatrics.
Purpose: The purpose is to serve as a comprehensive reference on all major aspects of Haemophilus influenzae type b conjugate vaccines.
Audience: The book is of interest to researchers who work on vaccines and to those interested in the history of pediatrics. The lessons learned during the course of the development of the Haemophilus influenzae type b vaccines are of particular interest to those working on other conjugate vaccines.
Features: The book is well organized, with clear figures and tables and up-to-date references.
Assessment: This is a worthwhile reference for medical libraries and for researchers interested in Haemophilus influenzae type b and other conjugate vaccines. Several chapters, such as those on nontypable Haemophilus influenzae disease in adults and bacterial polysaccharide immune globulin, are somewhat distracting because they do not directly deal with the stated purpose of the book. Although the Haemophilus influenzae type b vaccines have had a significant impact on the practice of pediatrics, most physicians will not be interested in the detailed information provided in this volume.
Doody's Health Sciences Book Review Journal Book Review Journal
...comprehensive...of interest to researchers who work on vaccines and to those interested in the history of pediatrics...well organized, with clear figures and tables...a worthwhile reference for medical libraries and for researchers interested in Haemophilus influenzae type b and other conjugate vaccines.
Anne H. Rowley
This volume of the Infectious Disease and Therapy series focuses on the development of the Haemophilus influenzae type b vaccines and their clinical efficacy trials. The information is of great historic interest, because the vaccines have dramatically reduced Haemophilus influenza type b disease and nasopharyngeal colonization and have thus significantly affected the practice of pediatrics. The purpose is to serve as a comprehensive reference on all major aspects of Haemophilus influenzae type b conjugate vaccines. The book is of interest to researchers who work on vaccines and to those interested in the history of pediatrics. The lessons learned during the course of the development of the Haemophilus influenzae type b vaccines are of particular interest to those working on other conjugate vaccines. The book is well organized, with clear figures and tables and up-to-date references. This is a worthwhile reference for medical libraries and for researchers interested in Haemophilus influenzae type b and other conjugate vaccines. Several chapters, such as those on nontypable Haemophilus influenzae disease in adults and bacterial polysaccharide immune globulin, are somewhat distracting because they do not directly deal with the stated purpose of the book. Although the Haemophilus influenzae type b vaccines have had a significant impact on the practice of pediatrics, most physicians will not be interested in the detailed information provided in this volume.
Booknews
A comprehensive reference on all major aspects of Haemophilus influenzae type b Hib conjugate vaccines. Among the topics in 25 contributed chapters: immunological basis for PRP vaccines; immunobiology of protein carriers; structure/function relationships in vaccines; molecular epidemiology of Hib strains; molecular basis of antibody diversity; epidemiology in developed countries; principles for designing vaccine clinical studies; clinical studies in developing countries; bacterial polysaccharide immune globulin; and conclusions from immunogenicity studies, efficacy trials, and large-scale use of vaccines. Annotation c. Book News, Inc., Portland, OR booknews.com

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824791865
  • Publisher: Taylor & Francis
  • Publication date: 5/12/1994
  • Series: Infectious Disease and Therapy Series , #11
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 520
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.00 (d)

Table of Contents

Immunological Basis for PRP Vaccines; Perspectives on Vaccine Development; Conjugation: Design, Chemistry, and Analysis; Immunobiology of Protein Carriers; Quality Control; Structure/Function Relationships in Vaccines; Molecular Epidemiology of Hib Strains; Molecular Aspects of the Pathogenesis of Invasive Infections; Molecular Population Genetics; Molecular Basis of Antibody Diversity; Epidemiology in Developed Countries; Epidemiology in Developing Countries; Principles for Designing Vaccine Clinical Studies; Antibody Assays; Lessons from Clinical Studies; Clinical Studies in Developing Countries; Bacterial Polysaccharide Immune Globulin; Protection Efficacy Trials; Risk Factors in Transmission; Pathogenesis and Treatment of Infants and Children; Infection in Adults; Effect of Vaccination on Oropharyngeal Carriage; Conclusions from Immunogenicity Studies, Efficacy Trials and Large-Scale Use of Vaccine; Regulatory Perspectives in Vaccine Licensure; New Approaches to Polysaccharide Vaccines.

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