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Doody's Review ServiceReviewer: Anne H. Rowley, MD (Loyola University Medical Center)
Description: This volume of the Infectious Disease and Therapy series focuses on the development of the Haemophilus influenzae type b vaccines and their clinical efficacy trials. The information is of great historic interest, because the vaccines have dramatically reduced Haemophilus influenza type b disease and nasopharyngeal colonization and have thus significantly affected the practice of pediatrics.
Purpose: The purpose is to serve as a comprehensive reference on all major aspects of Haemophilus influenzae type b conjugate vaccines.
Audience: The book is of interest to researchers who work on vaccines and to those interested in the history of pediatrics. The lessons learned during the course of the development of the Haemophilus influenzae type b vaccines are of particular interest to those working on other conjugate vaccines.
Features: The book is well organized, with clear figures and tables and up-to-date references.
Assessment: This is a worthwhile reference for medical libraries and for researchers interested in Haemophilus influenzae type b and other conjugate vaccines. Several chapters, such as those on nontypable Haemophilus influenzae disease in adults and bacterial polysaccharide immune globulin, are somewhat distracting because they do not directly deal with the stated purpose of the book. Although the Haemophilus influenzae type b vaccines have had a significant impact on the practice of pediatrics, most physicians will not be interested in the detailed information provided in this volume.