Development of Human Gene Therapy #36 / Edition 1

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The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without.

"...chronicles the evolution of human gene therapy, illustrating how imaginative concepts have shaped the development of technologies & brought the new idea to its current position of imminent practical success."

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Editorial Reviews

Nature Magazine
Highlights of this large volume include an excellent chapter on naked DNA injection into various tissues. The fact that this leads to gene expression at all is remarkably encouraging for the future. Another chapter considers targeted gene repair in mammalian cells using chimaeric oligonucleotides. Although a long way from the clinic, this represents the beginnings of genetic surgery. The short review on stem-cell transplantation is concise, yet informative, while the ethics of the subject are well reviewed in a historical context.
Science Magazine
The Development of Human Gene Therapy is a timely and useful book that highlights the significant recent advances in the field. At the same time, it illuminates the important hurdles that remain to be overcome en route to a clinically useful reality.
Contributors from inside the discipline trace the unconventional 30- year development of gene therapy, which was widely accepted by the medical community and society at large long before there were any practical clinical results. They describe specific topics such as retroviral and lentiviral vectors, advances in synthetic gene-delivery system technology, naked DNA gene transfer in mammalian cells, the hematopoietic system as a target for gene therapy, suicide genes, the logic of anti-angiogenic gene therapy, apoptosis as a goal of cancer gene therapy, therapy for HIV and other viral infections, public policy and regulatory issues, and ethical issues in human gene transfer research. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780879695286
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 12/11/1998
  • Series: Monographs Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 744
  • Product dimensions: 7.13 (w) x 9.15 (h) x 1.41 (d)

Table of Contents

1 The Origins, Evolution, and Directions of Human Gene Therapy 1
2 Retroviral Vectors 21
3 Lentiviral Vectors 47
4 Structure and Genetic Organization of Adenovirus Vectors 61
5 Adenovirus Vectors 87
6 Strategies to Adapt Adenoviral Vectors for Gene Therapy Applications: Targeting and Integration 111
7 Adeno-associated Viral Vectors 131
8 Gene-transfer Tool: Herpes Simplex Virus Vectors 173
9 Emerging Viral Vectors 209
10 Advances in Synthetic Gene-delivery System Technology 241
11 Receptor-mediated Gene Delivery Strategies 261
12 Naked DNA Gene Transfer in Mammallan Cells 279
13 Delivery Systems and Adjuvants for DNA Vaccines 309
14 Targets for Gene Therapy 331
15 The Hematopoietic System as a Target for Gene Therapy 351
16 Cancer Immunotherapy 427
17 Gene Transfer and Stem-cell Transplantation 459
18 Suicide Genes: Gene Therapy Applications Using Enzyme/Prodrug Strategies 477
19 The Logic of Anti-angiogenic Gene Therapy 527
20 Apoptosis as a Goal of Cancer Gene Therapy 545
21 Advances in Gene Therapy for HIV and Other Viral Infections 573
22 Progress toward Gene Therapy for Nervous System Diseases 607
23 Targeted Gene Repair in Mammalian Cells Using Chimeric RNA/DNA Oligonucleotides 643
24 Human Gene Therapy: Public Policy and Regulatory Issues 671
25 Ethical Issues in Human Gene Transfer Research 691
Index 713
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  • Anonymous

    Posted February 1, 2000

    Biotechnology Student Review

    This book is an excellent source of current information relative to gene therapy. It is however, very wordy, and is extremely lacking in illustrations. In fact, the few illustrations the book has rate about a C+. This book was my textbook. How unfortunate for me! It should probably be avoided as a textbook unless you already have a course or two of virology, recombinant DNA, and/or immunology. I think it is also important to note that each chapter has different authors, so forget about continuity in ideas, and expression. The gene therapy treatment however, is very good. I must say that I learned an awful lot during my gene therapy semester, but I had to use other true textbooks to reinforce or rather to explain what I was reading in this book. It was a tough semester. For the section on viruses (the first few chapters), I needed other texts to explain what was going on. If you've had a course in recombinant DNA, you can muck through the transfection chapters (since details aren't exposed). I believe this book was written to be a reference for gene therapists, not students. It cites many, many experiments, and the bibliographies at the end of each chapter are very impressive. Good luck, and don't expect to read this thing in a week.

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