Development of Human Gene Therapy #36 / Edition 1

Development of Human Gene Therapy #36 / Edition 1

by Theodore Friedmann
     
 

The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought… See more details below

Overview

The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without.

Product Details

ISBN-13:
9780879695286
Publisher:
Cold Spring Harbor Laboratory Press
Publication date:
12/11/1998
Series:
Monographs Series
Edition description:
New Edition
Pages:
744
Product dimensions:
7.13(w) x 9.15(h) x 1.41(d)

Related Subjects

Table of Contents

Preface
1The Origins, Evolution, and Directions of Human Gene Therapy1
2Retroviral Vectors21
3Lentiviral Vectors47
4Structure and Genetic Organization of Adenovirus Vectors61
5Adenovirus Vectors87
6Strategies to Adapt Adenoviral Vectors for Gene Therapy Applications: Targeting and Integration111
7Adeno-associated Viral Vectors131
8Gene-transfer Tool: Herpes Simplex Virus Vectors173
9Emerging Viral Vectors209
10Advances in Synthetic Gene-delivery System Technology241
11Receptor-mediated Gene Delivery Strategies261
12Naked DNA Gene Transfer in Mammallan Cells279
13Delivery Systems and Adjuvants for DNA Vaccines309
14Targets for Gene Therapy331
15The Hematopoietic System as a Target for Gene Therapy351
16Cancer Immunotherapy427
17Gene Transfer and Stem-cell Transplantation459
18Suicide Genes: Gene Therapy Applications Using Enzyme/Prodrug Strategies477
19The Logic of Anti-angiogenic Gene Therapy527
20Apoptosis as a Goal of Cancer Gene Therapy545
21Advances in Gene Therapy for HIV and Other Viral Infections573
22Progress toward Gene Therapy for Nervous System Diseases607
23Targeted Gene Repair in Mammalian Cells Using Chimeric RNA/DNA Oligonucleotides643
24Human Gene Therapy: Public Policy and Regulatory Issues671
25Ethical Issues in Human Gene Transfer Research691
Index713

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