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Development of the electrostatic corral for the trapping of single molecules in solution.

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Overview

In this thesis the development of a novel tool, the "corral trap" is presented. The mechanism behind the function of the corral trap is based on pure electrostatic charges and the resulting creation of a stable potential energy well for the trapping of micro- and nano-scale objects. The electrostatic corral acts as an "invisible fence" which is precisely controlled by varying the applied voltage. This new technique allows for the isolation of single molecules in their native environment for long term studies of their dynamics or interactions with binding partners. The development of new trapping techniques holds enormous potential for new types of measurements at the molecular scale. Molecules no longer need to be artificially immobilized or constrained in their motion through invasive means in order to be observed over extended periods of time.;The contents of this thesis can be divided into two main areas: (1) The fabrication of a micro-scale version using conventional micropatterning techniques. After extensive investigation into the fabrication and characterization of the micro-scale electrostatic trap it was successfully used for the trapping of micro- and nano-scale objects as well as the successful trapping of single molecules. In addition, the simultaneous trapping of multiple objects has been successfully accomplished. (2) The initial development of photonic crystal fiber optical probes for future use, in conjunction with a near-field scanning optical microscopy system, as a nano-scale electrostatic trap for the capture and manipulation of single molecules. To this end several fabrication techniques were investigated with comparisons of the results for both conventional single-mode optical fibers and photonic crystal fibers. After a fabrication technique was developed, the procedure was optimized for several environmental factors to generate reproducible photonic crystal fiber optical probes with optimum probe properties.
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Product Details

  • BN ID: 2940043518026
  • Publisher: ProQuest LLC
  • Sold by: Barnes & Noble
  • Format: eTextbook
  • Pages: 239

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