Development of Therapeutic Agents Handbook

Overview

A comprehensive look at current drug discovery and development methods—and the roadmap for the future

Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and ...

See more details below
Other sellers (Hardcover)
  • All (11) from $136.12   
  • New (7) from $161.00   
  • Used (4) from $136.12   
Development of Therapeutic Agents Handbook

Available on NOOK devices and apps  
  • NOOK Devices
  • Samsung Galaxy Tab 4 NOOK
  • NOOK HD/HD+ Tablet
  • NOOK
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
$149.99
BN.com price
(Save 42%)$263.00 List Price

Overview

A comprehensive look at current drug discovery and development methods—and the roadmap for the future

Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes:

  • Extensive coverage and in-depth look into novel treatments and therapeutics
  • Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews
  • Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases

As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.

Read More Show Less

Editorial Reviews

From the Publisher
“The text is well-written and includes extensive references.” (Book News, 1 April 2012)
Read More Show Less

Product Details

  • ISBN-13: 9780471213857
  • Publisher: Wiley
  • Publication date: 12/6/2011
  • Series: Pharmaceutical Development Series , #8
  • Edition number: 1
  • Pages: 680
  • Product dimensions: 8.70 (w) x 11.10 (h) x 2.10 (d)

Meet the Author

SHAYNE COX GAD, PhD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than thirty years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of forty-two books and numerous papers, presentations, and other publications.

Read More Show Less

Table of Contents

PREFACE ix

CONTRIBUTORS xi

PART I FUNDAMENTAL CONCEPTS 1

1. Current Needs for New Therapeutic Agents and Discovery Strategies—A Systems Pharmacology Approach 3
Sophie C. Desbiens and David H. Farb

2. Target Selection in Drug Discovery 25
Charles F. Albright

3. New Drug Applications 35
John S. McInnes and Donald O. Beers

4. From Concept to the Clinics: Development of Cancer Therapeutics 47
Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary

5. Development of Countermeasures for Bioterrorism in the United States 73
Gregory H. Levine and Jeffrey I. Handwerker

6. Development and Application of Conformation-Selective Integrin Antibodies 91
Nathan S. Astrof, Dan Peer, and Motomu Shimaoka

7. Pain Management Market Overview 113
Anita Holdcroft

8. Antiviral Market Overview 127
Anita Arora, Natalia Mendoza, and Stephen K. Tyring

PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145

9. High-Throughput Screening for Small-Molecule Drug Discovery 147
C. Parker and J.-H. Zhang

10. Mass Spectrometry 181
Robert D. English and Anthony M. Haag

11. Molecular Screening for Therapeutic Agents 207
R. Damoiseaux

12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241
Zhengdong Cheng

13. Development of Antimicrobial Peptides as Therapeutic Agents 285
Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant

14. Antibodies for Human Diseases 359
Guo-Liang Yu and Jian Ni

15. Combinatorial Compounds and Drug Discovery 399
James C. Bigelow

16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413
David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim

17. RNAi-Mediated Therapeutics 425
Nuria Morral and Scott R. Witting

18. Crystallography 445
Carl H. Schwalbe

19. PEGylation 463
Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal

20. Gold Standard Animal Models 517
Carol Casteneda and Michael S. LaPointe

21. Discovery of Vaccine Adjuvants 533
Fiona A. Sharp and Ed C. Lavelle

22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547
Hye J. Lee and Chanmi Choi

23. Aerosol Drug Delivery to the Lungs 565
Andrew R. Martin and Warren H. Finlay

24. Resistance to Antiplatelet Theraphy 589
Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino

25. Antibiotic Development 611
Robert L. Bettiker and Jason C. Gallagher

PART III THERAPEUTIC TOPICS 629

26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631
Shu Yeong Queck and Michael Otto

27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645
Byungse Suh and Rafi k Samuel

28. Anti-Inflammatory Therapeutics 655
Marion M. Chan and Dunne Fong

29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673
Kelly L. Brown

30. Cardiovascular Disease: In-Depth Look 707
Nicholas B. Norgard and Mazen Abu-Fadel

31. Ezetimibe and Cholesterol Absorption 723
Stefan Oswald and Werner Siegmund

32. Cardiology—In-Depth Look: Kinases as Therapeutic Targets in the Heart 743
Karin Mauer and J. Emilio Exaire

33. Statins in the Reduction of Cardiovascular Events 773
Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta

34. Cardiology—In-Depth Look: Advances in Antiplatelet Theraphy 785
Karin Mauer and Jorge F. Saucedo

35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813
Brian Hemstreet

36. Pharmacology of Vasopressin and the Renin—Angiotension—Aldosterone System 825
Elizabeth J. Brant and Julian L. Seifter

37. New Drugs and Nutaceutical in the Treatment of Osteoarthristis 847
Y. Henrotin and J. Y. Reginster

38. Development of Anticytokine Agents for Rheumatoid Arthritis 881
Jonathan Sherlock, Christopher D. Buckley, and Karim Raza

39. Overview of CNS Neuropharmaceuticals 897
Tauser Roxana-Georgiana and Antohe Dan-Stefan

40. Thinking Outside the Box in Alzheimer Disease Treatment 929
Rudy J. Castellani, Michael W. Marlatt, Akihiko Nunomura, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Xiogwei Zhu, George Perry, and Mark A, Smith

41. Neurotrophic Factors as Novel Therapeutic Targets 943
Stephen D. Skaper

42. Oncology 963
Arkadiusz Z. Dudek and Steven F. Powell

43. Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia 999
Muhammad Mansoor Alam and Moshe Talpaz

44. Aromatase Inhibitors for Breast Cancer 1011
Akm Hossain and Jame Abraham

45. Evolution of Selective Estrogen and Androgen Receptor Modulators: Status of Current Therapy and New Drug Development 1019
Gregory T. Wurz and Michael W. DeGregorio

46. In-Depth Look: anti-TNF-α Therapies 1045
Satadal Chatterjee and Shobhan Gaddameedhi

47. Development of Therapeutic Agents: The Maternal—Fetal Perspective 1093
C. Gedeon, F. Garcia Bournissen and G. Koren

48. History of Antipsychotic Drug Development 1111
Shankar S. Gollapudi and Rajan Radhakrishnan

49. Radiopharmaceuticals and Medical Imaging: Development of Radioimmumoconjugates for Radioimmunoimaging and Radioimmunotherapy of Malignant Diseases 1137
Gang Niu and Xiaoyuan Chen

50. Therapeutic Drug Development for Kidney Diseases 1159
Mitchell H. Rosner, Joshua King, and Peter Monteleone

51. Targeting Chemokines and Angiogenesis in Arthritis 1185
Zoltan Szekaneez and Alisa E Koch

52. Development of Therapeutic Agents: Methods and Approaches in the Development of Vaccines against Protozoan Parasites 1207
Catherine Ivory and Kris Chadee

53. Toxicology 1221
John H. Duffus

54. The Development of Phosphodiesterase 4 Inhibitors for Allergic and Nonallergic Infl ammatory Diseases of the Airways 1233
Mark A. Giembycz

INDEX 1251

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)