Developmental Toxicology

Overview

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and ...

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Overview

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs.

The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed.

Key topics include:


  • the roles of apoptosis and signal transduction pathways in normal and abnormal development
  • the role of epigenetic changes in development
  • the role of nutrition and individual susceptibility
  • the utility of bioinformatics
  • global and targeted gene expression changes
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Editorial Reviews

Doody's Review Service
Reviewer: Andrea L Christiansen, MS (Oregon State University)
Description: This book is a compilation of contemporary issues in developmental toxicology that build upon the two earlier, more basic editions, the last of which was published in 1994. Chapters generally provide sufficient or even generous introductions to the topics, then elaborate using notable examples or case studies.
Purpose: The purpose is to detail advances in the understanding of developmental toxicology and its risk assessment since the last edition, with the ultimate goal of preventing birth defects through knowledge. This is particularly important, considering how much new knowledge has accumulated in 15 years. The book achieves its goal, but it would be helpful if it had provided a guide or reading list for prominent case studies not discussed in the book.
Audience: This would be a useful reference for physicians, researchers, and risk assessors/policy-makers, as well as those pursuing graduate studies or in industry. The authors write with authority.
Features: The role of nutrition, genetic, and other molecular mechanisms' involvement in adverse developmental effects is explored. New methods, models, and model systems used for understanding and assessing risk are also detailed. The most robust sections are those covering advances in the understanding of the molecular basis for toxicology, and the new methods being used to address the challenge of understanding the complexities of toxicant interactions in development.
Assessment: This book is unique in that it contains little of the basic information normally expected to be included. Rather, it expands on the earlier basic books, using primarily case studies to illustrate the topics. The introductions provide enough context to understand the emerging field, but some introductions may be too extensive. The format of the chapters is not highly consistent. Some chapters would benefit from images, perhaps from the publications discussed in the text. Many chapters reflect the trend towards interdisciplinary studies for understanding life. This book is not intended to replace a fundamental book about developmental toxicology. However, this new edition is completely justified considering the new information gained from research in this field and the importance of remaining current.
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Product Details

  • ISBN-13: 9781420054378
  • Publisher: CRC Press
  • Publication date: 10/24/2008
  • Series: Target Organ Toxicology Series
  • Edition description: REV
  • Edition number: 3
  • Pages: 496
  • Product dimensions: 6.20 (w) x 9.00 (h) x 1.00 (d)

Meet the Author

DEBORAH K. HANSEN is a research biologist in the Division of Genetic and Reproductive Toxicology, the National Center for Toxicological Research, Jefferson and Adjunct Associate Professor of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. She received her M.S. in genetics from Iowa State University, Ames, Iowa and her Ph.D. in medical genetics from Indiana University School of Medicine, Indianapolis, Indiana, USA. Dr. Hansen is a member of both the Teratology Society, of which she is Secretary, and the Society of Toxicology. She has contributed to numerous peer-reviewed publications on the subjects of reproductive toxicology, embryotoxicity, and developmental toxicology.

BARBARA D. ABBOTT is Research Biologist in the Reproductive Toxicology Division of the U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA. She received both her M.S. and Ph.D. in toxicology from North Carolina State University, Raleigh, North Carolina, USA. Dr. Abbott is a member of the Teratology Society and the Society of Toxicology. She is Associate Editor of Toxicological Sciences and serves on the editorial board of Reproductive Toxicology. Dr. Abbott has also received several Scientific and Technological Achievement awards from the U.S. EPA and has been a frequent invited lecturer at international meetings and symposiums. Her main area of interest is developmental toxicity, particularly complex, interactive signal transduction and receptor-mediated pathways.

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Table of Contents

1. Role of Apoptosis in Normal and Abnormal Development. 2. Signal transduction pathways as targets for teratogens. 3. Nutrition in Developmental Toxicology. 4. Epigenetic Mechanisms-Role of DNA Methylation, Histone Modifications and Imprinting. 5. Personalized Nutrition and Medicine in Perinatal Development. 6. Targeted Gene changes affecting Developmental Toxicity. 7. Use of mammalian in vitro systems, including embryonic stem cells, in developmental toxicity testing. 8. Zebrafish: a Non-Mammalian Model of Developmental Toxicology. 9. Physiologically-Based Pharmacokinetic Modeling in the risk assessment of developmental toxicants. 10. Integration of whole animal developmental toxicity data into risk assessment. 11. Genomic Approaches in Developmental Toxicology. 12. Comparative Bioinformatics and Computational Toxicology. 13. Investigating Drug Effects in Human Pregnancy.

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