Diabetes and Ocular Disease: Past, Present, and Future Therapies / Edition 2

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Diabetes mellitus is a complex, multifactorial disease that is often associated with progressive retinopathy and visual loss. In this book, Drs. Scott, Flynn, and Smiddy have compiled the current basic science and clinical information from leading authorities on diabetic eye disease. They have also included the results of clinical trials in patients with diabetic retinopathy, as well as the guidelines established by collaborative studies and the concepts of disease mechanisms and clinical management that have subsequently evolved from those guidelines. This monograph will provide practitioners with a concise, up-to-date, practical reference for the diagnosis and management of ocular disease in diabetic patients.

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Editorial Reviews

Doody's Review Service
Reviewer: Paul Hahn, MD, PhD (University of Pennsylvania School of Medicine)
Description: Foremost authorities in the field present a comprehensive examination of various ophthalmologic aspects of diabetes, including historic perspectives, current understanding, and speculation on future directions in this update of an Ophthalmology Monograph originally published in 2000.
Purpose: The purpose is to provide a resource for ophthalmologists, researchers, residents, and medical students. The book presents an overview of systemic diabetes and then focuses on its effects on the eye, with chapters on various aspects including epidemiology, imaging, treatment options, and exciting future therapies. The book is comprehensive and certainly meets the authors' objectives.
Audience: According to the authors, the book is targeted at "ophthalmologists, researchers, as well as residents and medical students" and it is appropriate for this audience.
Features: The book presents a directed exploration of diabetes as it relates to ocular disease. Beginning with an overview of the epidemic of diabetes in a worldwide/systemic setting, the book then focuses its discussion on classification, pathogenesis/histopathology, epidemiology, imaging, and treatment modalities (current and possible future options) for diabetic ocular disease, particularly diabetic retinopathy. The book nicely covers historic perspectives as a means to understand current practice and uses color figures and tables to detail important points. The book is current, relevant, and comprehensive. Specific details, particularly those pertaining to past landmark studies, could have been outlined more extensively, but certainly there is a need to balance detail with brevity, which this book achieves well.
Assessment: This will be extremely useful to any ophthalmologist, concisely providing useful information on current, future, and past therapies communicated by leaders in the field. Undoubtedly, there have been changes in this field, particularly advances in therapies and imaging modalities, and this second edition is a welcome update of the first.
From the Publisher
"This is a welcome second edition of the now classic text by Drs. Scott, Flynn, and Smiddy, renowned international authorities in the management of diabetic retinopathy and related ocular complications. The writing is clear and concise, highlights the core messages, and includes an extensive bibliography for additional reading by those who wish to probe further than the already comprehensive treatment provided in this text. Areas that will undoubtedly assume increasing importance, including telemedicine, anti-angiogenic strategies, and results from multi-center collaborative trials are well covered. This is a must-have volume for any ophthalmologist who sees patients with diabetes, regardless of subspecialty." — Mark S. Blumenkranz, M.D., Professor and Chairman, Ophthalmology, Stanford University School of Medicine

"A masterpiece of the effects of diabetes on the eye that is both a practical guide as well as a useful reference for evidence based studies. Kudos to the editors for assembling a group of international experts in a comprehensive treatment of this topic!" — Stanley Chang, M.D, Edward Harkness Eye Institute, New York

"This book is the definitive reference on ocular involvement from diabetes melliitus. The world's experts discuss pathophysiology, clinical manifestations,medical and surgical treatment and research frontiers of diabetic retinopathy . The various past, present, and future clinical trials on diabetic patients including an up to date review of newer studies and newer concepts are summarized for the reader.The writing is clear and succinct . This book is ideal for medical students, residents, fellows or practitioners." — Lee Jampol , M.D., Louis Feinberg Professor, Department of Ophthalmology, Feinberg School of Medicine, Northwestern University

"This will be extremely useful to any ophthalmologist, concisely providing useful information on current, future, and past therapies communicated by leaders in the field. Undoubtedly, there have been changes in this field, particularly advances in therapies and imaging modalities, and this second edition is a welcome update of the first."—Doody's

"...an excellent text for those wishing to delve into this important topic in more detail." —Jama

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Product Details

Meet the Author

Ingrid Scott is Professor of Ophthalmology and Health Evaluation Sciences, Penn State College of Medicine

Harry Flynn is Professor and The J. Donald M. Grass Distinguished Chair of Ophthalmology, Bascol Palmer Eye InstituteWES: Professor of Ophthalmology, Bascom Palmer Eye Institute

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Table of Contents

Ingrid U. Scott, MD, MPH and Harry W. Flynn, Jr., MD

Chapter 1: Medical Overview of the Worldwide Diabetes Epidemic
Robert E. Leonard II, MD and David W. Parke II, MD

Chapter 2: Classification of Diabetic Retinopathy
Charles P. Wilkinson, MD

Chapter 3: Histopathological Manifestations of Diabetic Retinopathy
Matthew Guess, MD and Sander R. Dubovy, MD

Chapter 4: Pathogenesis of Diabetic Retinopathy
Thomas W. Gardner, MD, MS and Lloyd Paul Aiello, MD, PhD

Chapter 5: Epidemiology and Risk Factors of Diabetic Retinopathy
Tien Y. Wong, MD, PhD, Ronald Klein, MD, MPH, and Barbara E. K. Klein, MD, MPH

Chapter 6: History of Evolving Treatments for Diabetic Retinopathy
George W. Blankenship, MD

Chapter 7: Photography, Angiography, and Ultrasonography in Diabetic Retinopathy
Andrew Lam, MD, Nicholas G. Anderson, MD, Carl D. Regillo, MD, and Gary C. Brown, MD, MBA

Chapter 8: Optical Coherence Tomography in the Management of Diabetic Retinopathy
Andrew A. Moshfeghi, MD, Ingrid U. Scott, MD, MPH, Harry W. Flynn, Jr., MD, and Carmen A. Puliafito, MD, MBA

Chapter 9: Clinical Studies on Treatment for Diabetic Retinopathy
Frederick L. Ferris III, MD, Matthew D. Davis, MD, Lloyd M. Aiello, MD, and Emily Y. Chew, MD

Chapter 10: Photocoagulation for Diabetic Macular Edema and Diabetic Retinopathy
Mitchell J. Goff, MD, H. Richard McDonald, MD, and Everett Ai, MD

Chapter 11: Vitrectomy for Diabetic Retinopathy
William E. Smiddy, MD and Harry W. Flynn, Jr., MD

Chapter 12: Intravitreal Pharmacotherapies for Diabetic Retinopathy
Sophie J. Bakri, MD and Peter K. Kaiser, MD

Chapter 13: Evolving Algorithms for Managing Diabetic Macular Edema
Diana V. Do, MD and Julia A. Haller, MD

Chapter 14: Management of Diabetic Retinopathy: Evidence-based Systematic Review
Quresh Mohamed, MD, Mark C. Gillies, MD, PhD, and Tien Y. Wong, MD, PhD

Chapter 15: Cataract Management in Diabetes
Mitchell S. Fineman, MD, William E. Benson, MD, Ingrid U. Scott, MD, MPH

Chapter 16: Nonretinal Ocular Abnormalities in Diabetes
Ingrid U. Scott, MD, MPH and Harry W. Flynn, Jr., MD

Chapter 17: The Effect of Systemic Conditions on Diabetic Retinopathy
Emily Y. Chew, MD

Chapter 18: Medical Management of the Diabetic Patient
Jay S. Skyler, MD

Chapter 19: Telemedicine for Diabetic Retinopathy
Helen K. Li, MD and Matthew T. S. Tennant, MD

Chapter 20: Future Therapies: Rationale for and Status of Anti-angiogenic and Anti-permeability Interventions
Nigel H. Timothy, MD, Jennifer K. Sun, MD, Jerry Cavallerano, OD, PhD, Thomas W. Gardner, MD, MS, and Lloyd Paul Aiello, MD, PhD

Appendix: Abstracts of Major Collaborative Multicenter Trials for Diabetic Retinopathy
Compiled by Nauman A. Chaudhry, MD, Ingrid U. Scott, MD, MPH, and Harry W. Flynn, Jr., MD


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