Diabetes and Ocular Disease: Past, Present, and Future Therapies / Edition 2

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Diabetes mellitus is a complex, multifactorial disease that is often associated with progressive retinopathy and visual loss. In this book, Drs. Scott, Flynn, and Smiddy have compiled the current basic science and clinical information from leading authorities on diabetic eye disease. They have also included the results of clinical trials in patients with diabetic retinopathy, as well as the guidelines established by collaborative studies and the concepts of disease mechanisms and clinical management that have subsequently evolved from those guidelines. This monograph will provide practitioners with a concise, up-to-date, practical reference for the diagnosis and management of ocular disease in diabetic patients.

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Editorial Reviews

Doody's Review Service
Reviewer: Paul Hahn, MD, PhD (University of Pennsylvania School of Medicine)
Description: Foremost authorities in the field present a comprehensive examination of various ophthalmologic aspects of diabetes, including historic perspectives, current understanding, and speculation on future directions in this update of an Ophthalmology Monograph originally published in 2000.
Purpose: The purpose is to provide a resource for ophthalmologists, researchers, residents, and medical students. The book presents an overview of systemic diabetes and then focuses on its effects on the eye, with chapters on various aspects including epidemiology, imaging, treatment options, and exciting future therapies. The book is comprehensive and certainly meets the authors' objectives.
Audience: According to the authors, the book is targeted at "ophthalmologists, researchers, as well as residents and medical students" and it is appropriate for this audience.
Features: The book presents a directed exploration of diabetes as it relates to ocular disease. Beginning with an overview of the epidemic of diabetes in a worldwide/systemic setting, the book then focuses its discussion on classification, pathogenesis/histopathology, epidemiology, imaging, and treatment modalities (current and possible future options) for diabetic ocular disease, particularly diabetic retinopathy. The book nicely covers historic perspectives as a means to understand current practice and uses color figures and tables to detail important points. The book is current, relevant, and comprehensive. Specific details, particularly those pertaining to past landmark studies, could have been outlined more extensively, but certainly there is a need to balance detail with brevity, which this book achieves well.
Assessment: This will be extremely useful to any ophthalmologist, concisely providing useful information on current, future, and past therapies communicated by leaders in the field. Undoubtedly, there have been changes in this field, particularly advances in therapies and imaging modalities, and this second edition is a welcome update of the first.
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Product Details

Meet the Author

Ingrid Scott is Professor of Ophthalmology and Health Evaluation Sciences, Penn State College of Medicine

Harry Flynn is Professor and The J. Donald M. Grass Distinguished Chair of Ophthalmology, Bascol Palmer Eye InstituteWES: Professor of Ophthalmology, Bascom Palmer Eye Institute

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Table of Contents

Contributors xiii

Chapter 1 Medical Overview of the Worldwide Diabetes Epidemic Robert E. Leonard David W. Parke 3

Chapter 2 Classification of Diabetic Retinopathy Charles P. Wilkinson 13

Chapter 3 Histopathology of Diabetic Retinopathy Matthew Guess Sander R. Dubovy 25

Chapter 4 Pathogenesis of Diabetic Retinopathy Thomas W. Gardner Lloyd Paul Aiello 49

Chapter 5 Epidemiology and Risk Factors of Diabetic Retinopathy Tien Y. Wong Ronald Klein Barbara E.K. Klein 71

Chapter 6 History of Evolving Treatments for Diabetic Retinopathy George W. Blankenship 101

Chapter 7 Photography, Angiography, and Ultrasonography in Diabetic Retinopathy Andrew Lam Nicholas G. Anderson Carl D. Regillo Gary C. Brown 123

Chapter 8 Optical Coherence Tomography in the Management of Diabetic Retinopathy Andrew A. Moshfeghi Ingrid U. Scott Harry W. Flynn Carmen A. Puliafito 139

Chapter 9 Clinical Studies on Treatment for Diabetic Retinopathy Frederick L. Ferris III Matthew D. Davis Lloyd M. Aiello Emily Y. Chew 161

Chapter 10 Photocoagulation for Diabetic Macular Edema and Diabetic Retinopathy Mitchell J. Goff H. Richard McDonald Everett Ai 183

Chapter 11 Vitrectomy for Diabetic Retinopathy William E. Smiddy Harry W. Flynn 207

Chapter 12 Intravitreal Pharmacotherapies for Diabetic Retinopathy Sophie J. Bakri Peter K. Kaiser 235

Chapter 13 Evolving Algorithms for Managing Diabetic Macular Edema Diana V. Do Julia A. Haller 251

Chapter 14 Management of Diabetic Retinopathy: Evidence-based Systematic Review Quresh Mohamed Tien Y. Wong 265

Chapter 15 Cataract Management in Diabetes Mitchell S. Fineman William E. Benson Ingrid U. Scott 301

Chapter 16 Nonretinal Ocular Abnormalities inDiabetes Ingrid U. Scott Harry W. Flynn 321

Chapter 17 The Effect of Systemic Conditions on Diabetic Retinopathy Emily Y. Chew 339

Chapter 18 Medical Management of the Diabetic Patient Jay S. Skyler 353

Chapter 19 Telemedicine for Diabetic Retinopathy Helen K. Li Matthew T.S. Tennant 373

Chapter 20 Future Therapies: Rationale for and Status of Antiangiogenic and Antipermeability Interventions Nigel H. Timothy Jennifer K. Sun Jerry Cavallerano Thomas W. Gardner Lloyd Paul Aiello 395

Chapter 21 Abstracts of Major Collaborative Multicenter Trials for Diabetic Retinopathy Ingrid U. Scott Nauman A. Chaudhry Harry W. Flynn 437

Glossary Ingrid U. Scott Harry W. Flynn 483

Index 487

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