Diabetes Mellitus: A Fundamental and Clinical Text / Edition 2

Diabetes Mellitus: A Fundamental and Clinical Text / Edition 2

by Derek Leroith, Jerrold M. Olefsky, Simeon I. Taylor

Thoroughly revised and updated, Diabetes Mellitus: A Fundamental and Clinical Text, Second Edition, encompasses the most recent advances in molecular and cellular findings and provides the newest therapeutic modalities for the disease. Adhering to the successful format of the first edition, this text is divided into 10 distinct sections, each containingSee more details below


Thoroughly revised and updated, Diabetes Mellitus: A Fundamental and Clinical Text, Second Edition, encompasses the most recent advances in molecular and cellular findings and provides the newest therapeutic modalities for the disease. Adhering to the successful format of the first edition, this text is divided into 10 distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutics. This book covers the complications of diabetes at both the basic and clinical levels, thus keeping the reader abreast of the latest developments of the disease, and is the perfect complement to Kahn's Joslin's Diabetes Mellitus.
New chapters include the importance of the characterization and cloning of sulfonylurea receptors, the role of lipids and its relationship to glucotoxicity, and the effects of GLP-1 during insulin secretion. Other coverage includes updates on such topics as the identification of "diabetes genes"; prevention and treatment of type I and type II diabetes; the role of GLP-1 and IRS-1 during insulin signaling; engineering of the pancreatic �-cell; principles of lipotoxicity and glucotoxicity; the role of adipose tissue in the pathogenesis of insulin resistance associated with obesity; and diet therapy and its effects on the treatment of type I and type II diabetes.

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Product Details

Lippincott Williams & Wilkins
Publication date:
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8.66(w) x 11.02(h) x (d)

Table of Contents

Contributing Authors
Pt. IInsulin Secretion
1Kinetics of Insulin Secretion: Underlying Metabolic Events2
2Insulin Gene Regulation11
3Processing of the Insulin Molecule20
4The Role of Glucose Transport and Phosphorylation in Glucose-Stimulated Insulin Secretion38
5Electrophysiology of the Pancreatic [beta]-Cell47
6Sulfonylurea Receptors, ATP-Sensitive Potassium Channels, and Insulin Secretion61
7GTP-Binding Proteins in the Regulation of Pancreatic [beta]-Cell Function78
8Insuliontropic Glucagon-Like Peptides94
9Insulin Secretion in Humans: Physiologic Regulation and Alternations in Disease States105
10Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell115
11Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms125
13Islet Amyloid and Its Potential Role in the Pathogenesis of Type 2 Diabetes Mellitus141
Pt. IIInsulin Action
14Physiologic Action of Insulin148
15Integration of Some Biochemical and Physiologic Effects of Insulin That May Play a Role in the Control of Blood Glucose Concentration161
16Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia176
17The Biochemistry of Insulin Action183
18The Insulin Receptor192
19Insulin Receptor Substrate Proteins Mediate Common Signaling Pathways for Insulin Action and [beta]-Cell Function199
20Regulation of Insulin Action by Protein-Tyrosine Phosphatases206
21Small GTPases and (Serine/Threonine) Protein Kinase Cascades in Insulin Signal Transduction218
22Protein Kinase C239
23Regulation of Glycogen Synthesis251
24Insulin Action on Glucose Transport264
25Vesicular Trafficking and GLUT-4 Translocation273
26Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes280
27A Role for Phosphodiesterase 3B in the Antilipolytic Action of Insulin284
28Gene Regulation291
29Insulin and Intracellular Ions305
30Insulin Degradation312
31Germline Manipulation of Glucose Transport and Glucose Homeostasis318
Pt. IIIDefinition and Classification
32Definition and Classification of Diabetes Mellitus and the New Criteria for Diagnosis326
Pt. IVType 1 Diabetes Mellitus
33Diabetic Ketocacidosis and the Hyperglycemic Hyperosmolar Syndrome336
34The Natural History of Autoimmunity in Type 1A Diabetes Mellitus347
35Humoral Autoimmunity363
36Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus374
37Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus383
38Major Histocompatibility Locus and Other Genes That Determine the Risk of Development of Type 1 Diabetes Mellitus399
39Association Between Immune-Mediated (Type 1) Diabetes Mellitus and Other Autoimmune Disease410
40Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus419
41Animal Models of Autoimmune Diabetes Mellitus430
42Insights From Transgenic and Gene Targeting Strategies in Type 1 Diabetes Mellitus441
Pt. VTherapeutics for Type 1 Diabetes Mellitus
43The Treatment of Diabetes Mellitus to Prevent and Delay Long-Term Complications: The Diabetes Control and Complications Trial456
44Application of the Diabetes Control and Complications Trial462
45Diet Therapy in Type 1 Diabetes Mellitus471
46Exercise for the Patient with Type 1 Diabetes Mellitus481
47Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus488
48Immune Intervention500
49Islet Cell Transplantation507
50Pancreas Transplantation518
51Gene Therapy for Metabolic Disease526
52Engineering the Pancreatic [beta]-Cell535
Pt. VIType 2 Diabetes Mellitus
53Epidemiology of Type 2 Diabetes Mellitus544
54Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus558
55Impaired Glucose Tolerance and Impaired Fasting Glucose: Risk Factors or Diagnostic Categories558
56Obesity in Type 2 Diabetes Mellitus567
57Effects of Aging on Glucose Homeostasis576
58Drug-Induced Diabetes Mellitus582
59Diabetes Mellitus Secondary to Other Endocrine Disorders588
60Insulin Secretin in Type 2 Diabetes Mellitus595
61Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and Coronary Heart Disease604
62Biochemical Defects of Insulin Action in Humans615
63Glucose Transporters and Pathophysiologic States627
64Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action641
65Tumor Necrosis Factor-[alpha] and the Insulin Resistance of Obesity651
66Fatty Acids and Insulin Resistance659
67Positional Cloning Strategies to Identify Causal Genes for Type 2 Diabetes Mellitus664
68Syndromes Associated with Insulin Resistance674
69Mutations in the Genes Encoding the Insulin Receptor and Insulin Receptor Substrate-1681
70Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus691
71Candidate Genes for Type 2 Diabetes Mellitus705
72Maternally Inherited Diabetes Mellitus and Deafness: New Subtype of Diabetes Mellitus719
73Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus723
74Primate Animal Models of Type 2 Diabetes Mellitus734
Pt. VIITherapeutics for Type 2 Diabetes Mellitus
75Prevention Strategies for Type 2 Diabetes Mellitus: A Health and Economic Perspective746
76Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load757
77Exercise in Patients With Type 2 Diabetes Mellitus765
78Insulin Secretogogues: Sulfonylureas and Meglitinides769
81[alpha]-Glucosidase Inhibitors in the Treatment of Diabetes797
82Combination Therapy in Type 2 Diabetes Mellitus804
83Intensive Insulin Therapy for Patients with Type 2 Diabetes Mellitus811
84Hypoglycemia in Type 2 Diabetes Mellitus827
85New Therapies to Increase Insulin Secretion836
Pt. VIIPregnancy
86Intermediatry Metabolism During Pregnancy: Implications for Diabetes Mellitus844
87Effects of Maternal Diabetes Mellitus on Intrauterine Development852
88Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications863
89Gestational Diabetes Mellitus881
Pt. IXDescriptive and Clinical Complications
90Pathophysiology of Diabetic Retinopathy890
91Pathophysiology of Diabetic Nephropathy898
92Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment910
93Diabetes Mellitus, Lipids, and Artherosclerosis934
94Pathogenesis of Hypertension in Diabetes Mellitus943
95Macrovascular Complications of Diabetes Mellitus957
96Skin and Diabetes Mellitus962
Pt. XMechanisms of Complications
97The Sorbitol-Osmotic and Sorbitol-Redox Hypotheses
98Advanced Glycation End Products and the Pathogenesis of Diabetic Complications983
99Hyperinsulinemia and insulin Resistance991
100The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications1000
101Oxidative Stress, Inflammation, and Diabetic Complications1008
102Protein Kinase C1016
103Neonatal Diabetes Mellitus1027
104Hypoglycemia in the Adult1029

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