Diabetes Mellitus: A Fundamental and Clinical Text / Edition 2

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Thoroughly revised and updated, Diabetes Mellitus: A Fundamental and Clinical Text, Second Edition, encompasses the most recent advances in molecular and cellular findings and provides the newest therapeutic modalities for the disease. Adhering to the successful format of the first edition, this text is divided into 10 distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutics. This book covers the complications of diabetes at both the basic and clinical levels, thus keeping the reader abreast of the latest developments of the disease, and is the perfect complement to Kahn's Joslin's Diabetes Mellitus.
New chapters include the importance of the characterization and cloning of sulfonylurea receptors, the role of lipids and its relationship to glucotoxicity, and the effects of GLP-1 during insulin secretion. Other coverage includes updates on such topics as the identification of "diabetes genes"; prevention and treatment of type I and type II diabetes; the role of GLP-1 and IRS-1 during insulin signaling; engineering of the pancreatic ¼-cell; principles of lipotoxicity and glucotoxicity; the role of adipose tissue in the pathogenesis of insulin resistance associated with obesity; and diet therapy and its effects on the treatment of type I and type II diabetes.

"...thoroughly revised and updated, this classic encompasses the most recent advances in molecular and cellular findings. ..covers the complications of diabetes at both the basic and clinical levels.

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Editorial Reviews

Rodney A. Hayward
Diabetes Mellitus: A Fundamental and Clinical Text is a detailed and comprehensive text that generally follows the traditional structure of major medical textbooks. It has extensive information on the basic science, physiology, and etiology of glucose metabolism, diabetes, and diabetic complications. The sections on diabetes classification, epidemiology, obesity, and type 1 diabetes are generally excellent.
Journal of American Medical Association
New edition of a text that encompasses the major advances in the basic molecular and cellular components of diabetes, as well as new therapeutic modalities. Each chapter is written as a focused review with extensive reference lists. The 104 contributions discuss insulin secretion and action, definition and classification, Type 1 and type 2 diabetes mellitus and therapeutics, pregnancy, descriptive and clinical complications, and mechanisms of complications. Edited by Derek LeRoith (Chief, Molecular Cellular Branch, National Institutes of Health), Simeon I. Taylor (MD, PhD, Bethesda, Md.), and Jerrold M. Olefsky (Division of Endocrinology and Metabolism, UCSD School of Medicine, San Diego). Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780781720588
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 5/28/2000
  • Edition description: REV
  • Edition number: 2
  • Pages: 1067

Table of Contents

Contributing Authors
Pt. I Insulin Secretion
1 Kinetics of Insulin Secretion: Underlying Metabolic Events 2
2 Insulin Gene Regulation 11
3 Processing of the Insulin Molecule 20
4 The Role of Glucose Transport and Phosphorylation in Glucose-Stimulated Insulin Secretion 38
5 Electrophysiology of the Pancreatic [beta]-Cell 47
6 Sulfonylurea Receptors, ATP-Sensitive Potassium Channels, and Insulin Secretion 61
7 GTP-Binding Proteins in the Regulation of Pancreatic [beta]-Cell Function 78
8 Insuliontropic Glucagon-Like Peptides 94
9 Insulin Secretion in Humans: Physiologic Regulation and Alternations in Disease States 105
10 Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell 115
11 Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms 125
12 Lipotoxity 132
13 Islet Amyloid and Its Potential Role in the Pathogenesis of Type 2 Diabetes Mellitus 141
Pt. II Insulin Action
14 Physiologic Action of Insulin 148
15 Integration of Some Biochemical and Physiologic Effects of Insulin That May Play a Role in the Control of Blood Glucose Concentration 161
16 Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia 176
17 The Biochemistry of Insulin Action 183
18 The Insulin Receptor 192
19 Insulin Receptor Substrate Proteins Mediate Common Signaling Pathways for Insulin Action and [beta]-Cell Function 199
20 Regulation of Insulin Action by Protein-Tyrosine Phosphatases 206
21 Small GTPases and (Serine/Threonine) Protein Kinase Cascades in Insulin Signal Transduction 218
22 Protein Kinase C 239
23 Regulation of Glycogen Synthesis 251
24 Insulin Action on Glucose Transport 264
25 Vesicular Trafficking and GLUT-4 Translocation 273
26 Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes 280
27 A Role for Phosphodiesterase 3B in the Antilipolytic Action of Insulin 284
28 Gene Regulation 291
29 Insulin and Intracellular Ions 305
30 Insulin Degradation 312
31 Germline Manipulation of Glucose Transport and Glucose Homeostasis 318
Pt. III Definition and Classification
32 Definition and Classification of Diabetes Mellitus and the New Criteria for Diagnosis 326
Pt. IV Type 1 Diabetes Mellitus
33 Diabetic Ketocacidosis and the Hyperglycemic Hyperosmolar Syndrome 336
34 The Natural History of Autoimmunity in Type 1A Diabetes Mellitus 347
35 Humoral Autoimmunity 363
36 Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus 374
37 Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus 383
38 Major Histocompatibility Locus and Other Genes That Determine the Risk of Development of Type 1 Diabetes Mellitus 399
39 Association Between Immune-Mediated (Type 1) Diabetes Mellitus and Other Autoimmune Disease 410
40 Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus 419
41 Animal Models of Autoimmune Diabetes Mellitus 430
42 Insights From Transgenic and Gene Targeting Strategies in Type 1 Diabetes Mellitus 441
Pt. V Therapeutics for Type 1 Diabetes Mellitus
43 The Treatment of Diabetes Mellitus to Prevent and Delay Long-Term Complications: The Diabetes Control and Complications Trial 456
44 Application of the Diabetes Control and Complications Trial 462
45 Diet Therapy in Type 1 Diabetes Mellitus 471
46 Exercise for the Patient with Type 1 Diabetes Mellitus 481
47 Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus 488
48 Immune Intervention 500
49 Islet Cell Transplantation 507
50 Pancreas Transplantation 518
51 Gene Therapy for Metabolic Disease 526
52 Engineering the Pancreatic [beta]-Cell 535
Pt. VI Type 2 Diabetes Mellitus
53 Epidemiology of Type 2 Diabetes Mellitus 544
54 Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus 558
55 Impaired Glucose Tolerance and Impaired Fasting Glucose: Risk Factors or Diagnostic Categories 558
56 Obesity in Type 2 Diabetes Mellitus 567
57 Effects of Aging on Glucose Homeostasis 576
58 Drug-Induced Diabetes Mellitus 582
59 Diabetes Mellitus Secondary to Other Endocrine Disorders 588
60 Insulin Secretin in Type 2 Diabetes Mellitus 595
61 Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and Coronary Heart Disease 604
62 Biochemical Defects of Insulin Action in Humans 615
63 Glucose Transporters and Pathophysiologic States 627
64 Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action 641
65 Tumor Necrosis Factor-[alpha] and the Insulin Resistance of Obesity 651
66 Fatty Acids and Insulin Resistance 659
67 Positional Cloning Strategies to Identify Causal Genes for Type 2 Diabetes Mellitus 664
68 Syndromes Associated with Insulin Resistance 674
69 Mutations in the Genes Encoding the Insulin Receptor and Insulin Receptor Substrate-1 681
70 Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus 691
71 Candidate Genes for Type 2 Diabetes Mellitus 705
72 Maternally Inherited Diabetes Mellitus and Deafness: New Subtype of Diabetes Mellitus 719
73 Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus 723
74 Primate Animal Models of Type 2 Diabetes Mellitus 734
Pt. VII Therapeutics for Type 2 Diabetes Mellitus
75 Prevention Strategies for Type 2 Diabetes Mellitus: A Health and Economic Perspective 746
76 Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load 757
77 Exercise in Patients With Type 2 Diabetes Mellitus 765
78 Insulin Secretogogues: Sulfonylureas and Meglitinides 769
79 Metformin 778
80 Thiazolidinediones 788
81 [alpha]-Glucosidase Inhibitors in the Treatment of Diabetes 797
82 Combination Therapy in Type 2 Diabetes Mellitus 804
83 Intensive Insulin Therapy for Patients with Type 2 Diabetes Mellitus 811
84 Hypoglycemia in Type 2 Diabetes Mellitus 827
85 New Therapies to Increase Insulin Secretion 836
Pt. VII Pregnancy
86 Intermediatry Metabolism During Pregnancy: Implications for Diabetes Mellitus 844
87 Effects of Maternal Diabetes Mellitus on Intrauterine Development 852
88 Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications 863
89 Gestational Diabetes Mellitus 881
Pt. IX Descriptive and Clinical Complications
90 Pathophysiology of Diabetic Retinopathy 890
91 Pathophysiology of Diabetic Nephropathy 898
92 Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment 910
93 Diabetes Mellitus, Lipids, and Artherosclerosis 934
94 Pathogenesis of Hypertension in Diabetes Mellitus 943
95 Macrovascular Complications of Diabetes Mellitus 957
96 Skin and Diabetes Mellitus 962
Pt. X Mechanisms of Complications
97 The Sorbitol-Osmotic and Sorbitol-Redox Hypotheses
98 Advanced Glycation End Products and the Pathogenesis of Diabetic Complications 983
99 Hyperinsulinemia and insulin Resistance 991
100 The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications 1000
101 Oxidative Stress, Inflammation, and Diabetic Complications 1008
102 Protein Kinase C 1016
103 Neonatal Diabetes Mellitus 1027
104 Hypoglycemia in the Adult 1029
Index 1039
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