Diabetes Mellitus: A Fundamental and Clinical Text / Edition 3

Diabetes Mellitus: A Fundamental and Clinical Text / Edition 3

by Jerrold M. Olefsky

Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications.

The text is divided into

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Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications.

The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

Product Details

Lippincott Williams & Wilkins
Publication date:
Edition description:
Third Edition
Product dimensions:
8.86(w) x 11.04(h) x 2.04(d)

Table of Contents

1The Two Phases of Glucose-Stimulated Insulin Secretion: Mechanisms and Controls3
2Insulin Gene Regulation15
3Processing of the Insulin Molecule27
4Electrophysiology of the Pancreatic [beta]-Cell51
5Sulfonylurea Receptors, Andenosine Triphosphate-Sensitive Potassium Channels, and Insulin Secretion69
6Insulinotropic Glucagon-Like Peptides99
7Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell115
8Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms129
10Islet Amyloid in Type 2 Diabetes151
11Physiologic Action of Insulin165
12Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations183
13Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia199
14The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation207
15The Insulin Signaling Network and Insulin Action225
16Knockout Mice as a Tool to the Understanding of Diabetes Mellitus245
17Regulation of Insulin Action by Protein-Tyrosine Phosphatases255
18Small GTPases and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction269
19Protein Kinase C301
20Regulation of Glycogen Synthesis317
21Insulin Action on Glucose Transport335
22Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation349
23Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes365
24Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion
25Gene Regulation383
26Insulin Degradation413
27Insulin and the Ras-Dependent Signaling Pathway421
28Germline Manipulation of Glucose Transport and Glucose Homeostasis431
29Molecular Links between Peroxisome Proliferator-Activated Receptor-[gamma] and Metabolic Disease441
30Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis457
31The Natural History of Autoimmunity in Type 1A Diabetes Mellitus471
32Genetics of Type 1 Diabetes483
33Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus499
34Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus519
35Major Histocompatibility Locus and Other Genes That Determine the Risk for Development of Type 1 Diabetes Mellitus539
36Associations between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases557
37Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus575
38Animal Models of Autoimmune Diabetes Mellitus591
39Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes611
40Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome627
41Application of the Diabetes Control and Complication Trial645
42Diet Therapy in Type 1 Diabetes Mellitus659
43Exercise for the Patient with Type 1 Diabetes Mellitus671
44Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus683
45Immune Intervention701
46Islet Cell Transplantation711
47Islet Transplantation721
48Pancreas Transplantation733
49Gene Therapy for Metabolic Disease747
50Surrogate [beta]-cells for Insulin Replacement Therapy763
51Stem Cells773
52Epidemiology of Type 2 Diabetes Mellitus785
53Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus797
54Noninvasive Imaging of Insulin Action and Resistance in Humans809
55Genetics of Human Obesity827
56Obesity: Treatment839
57Obesity in Type 2 Diabetes Mellitus857
58Effects of Aging Glucose Homeostasis869
59Drug-Induced Diabetes Mellitus879
60Insulin Secretion in Type 2 Diabetes Mellitus887
61Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome899
62Glucose Transporters and Pathophysiologic States917
63Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action939
64Inflammation, Tumor Necrosis Factor-[alpha], and Insulin Resistance953
65Adipokines: Regulators of Metabolic Integration and Energy Metabolism963
66Fatty Acids and Insulin Resistance979
67Triglyceride in Muscle987
68Candidate Genes for Type 2 Diabetes Mellitus1003
69Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipotrophic Diabetes1013
70Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus1029
71Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus1041
72Primate Animal Models of Type 2 Diabetes1059
73Preventing Type 2 Diabetes: The Diabetes Prevention Program1077
74Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load1085
75Exercise in Patients with Type 2 Diabetes Mellitus1099
76Insulin Secretogogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives1107
78Peroxisome Proliferator-Activated Receptor Modulators1139
79[alpha]-Glucosidase Inhibitors in the Treatment of Diabetes1151
81Combination Therapy in Type 2 Diabetes Mellitus1177
82Intensive Insulin Therapy for Patients with Type 2 Diabetes1191
83Hypoglycemia in Type 2 Diabetes Mellitus1213
84New Therapies to Promote Insulin Action1225
85Intermediary Metabolism during Pregnancy: Implications for Diabetes Mellitus1237
86Effects of Maternal Diabetes Mellitus on Intrauterine Development1251
87Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications1265
88Gestational Diabetes Mellitus1291
89Pathophysiology of Diabetic Retinopathy1303
90Pathogenesis of Diabetic Nephropathy1315
91Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment1331
92Diabetes Mellitus, Lipids, and Atherosclerosis1365
93Pathophysiology of Hypertension in Diabetes Mellitus1377
94Macrovascular Complications of Diabetes Mellitus1401
95Skin and Diabetes1411
96Neonatal Diabetes Mellitus1423
97Hypoglycemia in the Adult1427
98Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism1441
99Hyperinsulinemia and Insulin Resistance1457
100The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications1469
101Oxidative Stress, Inflammation, and Diabetic Complications1485
102Diabetic Vasculopathy1503

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