Diabetes Mellitus: A Fundamental and Clinical Text / Edition 3

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Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications.

The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

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Product Details

  • ISBN-13: 9780781740975
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 12/8/2003
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 1200
  • Product dimensions: 8.86 (w) x 11.04 (h) x 2.04 (d)

Table of Contents

1 The Two Phases of Glucose-Stimulated Insulin Secretion: Mechanisms and Controls 3
2 Insulin Gene Regulation 15
3 Processing of the Insulin Molecule 27
4 Electrophysiology of the Pancreatic [beta]-Cell 51
5 Sulfonylurea Receptors, Andenosine Triphosphate-Sensitive Potassium Channels, and Insulin Secretion 69
6 Insulinotropic Glucagon-Like Peptides 99
7 Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell 115
8 Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms 129
9 Lipotoxity 141
10 Islet Amyloid in Type 2 Diabetes 151
11 Physiologic Action of Insulin 165
12 Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations 183
13 Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia 199
14 The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation 207
15 The Insulin Signaling Network and Insulin Action 225
16 Knockout Mice as a Tool to the Understanding of Diabetes Mellitus 245
17 Regulation of Insulin Action by Protein-Tyrosine Phosphatases 255
18 Small GTPases and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction 269
19 Protein Kinase C 301
20 Regulation of Glycogen Synthesis 317
21 Insulin Action on Glucose Transport 335
22 Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation 349
23 Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes 365
24 Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion
25 Gene Regulation 383
26 Insulin Degradation 413
27 Insulin and the Ras-Dependent Signaling Pathway 421
28 Germline Manipulation of Glucose Transport and Glucose Homeostasis 431
29 Molecular Links between Peroxisome Proliferator-Activated Receptor-[gamma] and Metabolic Disease 441
30 Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis 457
31 The Natural History of Autoimmunity in Type 1A Diabetes Mellitus 471
32 Genetics of Type 1 Diabetes 483
33 Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus 499
34 Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus 519
35 Major Histocompatibility Locus and Other Genes That Determine the Risk for Development of Type 1 Diabetes Mellitus 539
36 Associations between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases 557
37 Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus 575
38 Animal Models of Autoimmune Diabetes Mellitus 591
39 Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes 611
40 Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome 627
41 Application of the Diabetes Control and Complication Trial 645
42 Diet Therapy in Type 1 Diabetes Mellitus 659
43 Exercise for the Patient with Type 1 Diabetes Mellitus 671
44 Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus 683
45 Immune Intervention 701
46 Islet Cell Transplantation 711
47 Islet Transplantation 721
48 Pancreas Transplantation 733
49 Gene Therapy for Metabolic Disease 747
50 Surrogate [beta]-cells for Insulin Replacement Therapy 763
51 Stem Cells 773
52 Epidemiology of Type 2 Diabetes Mellitus 785
53 Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus 797
54 Noninvasive Imaging of Insulin Action and Resistance in Humans 809
55 Genetics of Human Obesity 827
56 Obesity: Treatment 839
57 Obesity in Type 2 Diabetes Mellitus 857
58 Effects of Aging Glucose Homeostasis 869
59 Drug-Induced Diabetes Mellitus 879
60 Insulin Secretion in Type 2 Diabetes Mellitus 887
61 Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome 899
62 Glucose Transporters and Pathophysiologic States 917
63 Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action 939
64 Inflammation, Tumor Necrosis Factor-[alpha], and Insulin Resistance 953
65 Adipokines: Regulators of Metabolic Integration and Energy Metabolism 963
66 Fatty Acids and Insulin Resistance 979
67 Triglyceride in Muscle 987
68 Candidate Genes for Type 2 Diabetes Mellitus 1003
69 Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipotrophic Diabetes 1013
70 Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus 1029
71 Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus 1041
72 Primate Animal Models of Type 2 Diabetes 1059
73 Preventing Type 2 Diabetes: The Diabetes Prevention Program 1077
74 Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load 1085
75 Exercise in Patients with Type 2 Diabetes Mellitus 1099
76 Insulin Secretogogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives 1107
77 Metformin 1123
78 Peroxisome Proliferator-Activated Receptor Modulators 1139
79 [alpha]-Glucosidase Inhibitors in the Treatment of Diabetes 1151
80 Glinides 1163
81 Combination Therapy in Type 2 Diabetes Mellitus 1177
82 Intensive Insulin Therapy for Patients with Type 2 Diabetes 1191
83 Hypoglycemia in Type 2 Diabetes Mellitus 1213
84 New Therapies to Promote Insulin Action 1225
85 Intermediary Metabolism during Pregnancy: Implications for Diabetes Mellitus 1237
86 Effects of Maternal Diabetes Mellitus on Intrauterine Development 1251
87 Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications 1265
88 Gestational Diabetes Mellitus 1291
89 Pathophysiology of Diabetic Retinopathy 1303
90 Pathogenesis of Diabetic Nephropathy 1315
91 Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment 1331
92 Diabetes Mellitus, Lipids, and Atherosclerosis 1365
93 Pathophysiology of Hypertension in Diabetes Mellitus 1377
94 Macrovascular Complications of Diabetes Mellitus 1401
95 Skin and Diabetes 1411
96 Neonatal Diabetes Mellitus 1423
97 Hypoglycemia in the Adult 1427
98 Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism 1441
99 Hyperinsulinemia and Insulin Resistance 1457
100 The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications 1469
101 Oxidative Stress, Inflammation, and Diabetic Complications 1485
102 Diabetic Vasculopathy 1503
Index 1513
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