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Doody's Review ServiceReviewer: Marina Mosunjac, M.D.(Emory University School of Medicine)
Description: This up-to-date, practice-oriented book provides a comprehensive review of gynecologic and obstetric pathology.
Purpose: It offers a balance of the most up-to-date pathobiology of the diseases and practical approaches in solving complex diagnostic problems of everyday pathology, combined with clinically relevant information about the treatment, prognosis, and follow-up.
Audience: The book is primarily intended for practicing pathologists both in academic and private practice settings. However, the systematic approach to each disease, which includes the presentation, histopathology, differential diagnosis and treatment, accompanied by numerous high quality gross and microscopic pictures as well as comprehensive tables and diagnostic flow charts, will appeal to surgical pathology residents, gynecology residents and practicing gynecologic physicians.
Features: The book covers pathology of the female genital system, gestational disease, and disorders of the peritoneum. There is also a chapter on diseases of the anus, something rarely found in gynecology textbooks although it is a region that often shares common diseases with the gynecology system, such as HPV-related lesions. The chapter on cervical squamous neoplasia includes an up-to-date and comprehensive review of molecular biology and carcinogenesis of the HPV virus and a cytology overview with the detailed description and clinical management of ASCUS. Especially valuable are practical pointers such as guidelines for a positive margin of cone biopsy, problems with interpretation of cauterized margins or how to resolve discordant cytology and biopsy results. A separate chapter on benign cervical pathology is not included, although thorough descriptions of all the benign conditions that can mimic squamous intraepithelial neoplasia are included in the chapter on cervical intraepithelial neoplasia. The chapter on the lesions of benign endometrial disorders covers practical issues in patterns that are commonly associated with dysfunctional bleeding. Several comprehensive tables include the major pathology changes of benign endometrial disorders. However, if you try to search for the term simple or complex endometrial hyperplasia in the index, you will be led to the chapter on endometrial intraepithelial neoplasia (EIN), a term not all gynecologic clinicians or pathologists have adopted yet. Besides wonderful histologic descriptions, differential diagnosis, and immunohistochemical staining patterns of ovarian tumors, a special chapter on intraoperative evaluation of ovarian tumors makes this part of the book a highlight. Many have been waiting for a chapter like this since their residency days in the frozen section room when all of the "yellow tumors" in the ovaries looked the same grossly. This chapter offers another look at ovarian neoplasms from a different perspective grouping them by their gross appearance, clinical presentation and similarities in the cell appearance or structure. This is a wonderful chapter to peek at just before you're going to work on a frozen section of an ovarian mass. The three chapters on gestational disease are packed with excellent gross and microscopic pictures and include more than a few comprehensive tables full of valuable clinical morphological and laboratory data important for differential diagnosis. An additional chapter on gestational disease and the placenta integrates the most common clinical scenarios associated with pathological examination of the placenta offering us a different angle to the same pathological changes described in a previous chapter. Three appendixes are no less important than the rest of the book. The list of common diagnostic terms and comments as well as sample reports should serve as the guidelines for a proper, comprehensive, and complete surgical report, as a means of effective communication of data to clinicians, particularly where much of the information can be lost in unnecessary and long microscopic descriptions.
Assessment: This excellent resource for practicing pathologists, pathology residents, and gynecologic practitioners offers an up-to-date comprehensive review of pathobiology, morphology, new diagnostic techniques, treatment options, and prognosis. At the same time it gives numerous "pearls of wisdom" pointing out practical issues in everyday sign-out. The book is written in a systematic, organized, logical, and easy to read fashion and is accompanied by an abundance of high quality color pictures, comprehensive tables, and diagnostic flow charts.