Diagnostic Immunohistochemistry: Theranostic and Genomic Applications

by David J Dabbs MD (Editor)

Overview

User-friendly and concise, the new edition of this popular reference is your #1 guide for the appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in the field use a consistent, organ system approach to cover all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Each well-written and well-researched chapter is enhanced with diagnostic algorithms, charts, tables, and superb, full-color histologic images, making this text a practical daily resource for all surgical pathologists.

• Features a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
• Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
• Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.

• Contains new material on non-lymphoid malignancies, Hodgkin/non-Hodgkin lymphoma, and an expanded chapter on digital imaging and quantitative immunohistochemistry.
• Provides new grading schemes for several organs, along with new antibodies to cover more genomic immunohistochemistry applications.
• Offers more emphasis in the breast section of "eyes on" tissue for molecular/IHC prognostics compared to the current trend of gene-expression profiling of breast cancer.
• Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Product Details

ISBN-13:	9780323721721
Publisher:	Elsevier Health Sciences
Publication date:	12/03/2021
Edition description:	6th ed.
Pages:	1000
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Dr Dabbs has twenty years of experience in the surgical pathology of solid tumors, with additional subspecialty-focused interest in the study of tumors of unknown origin, breast carcinoma, gynecologic pathology and tumor cytopathology. He served as Member of Medical & Scientific Advisory Board of US LABS, Inc. He offers national workshops in breast pathology and immunohistochemistry and has presented more than 100 papers in peer-reviewed journals and at national meetings

Table of Contents

1. Techniques of Immunohistochemistry: Principles, Pitfalls, and Standardization

2. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis

3. Immunohistology of Infectious Diseases

4. Immunohistology of Neoplasms of Soft Tissue and Bone

5. Immunohistology of Bone Marrow, Spleen and Histiocytic Disorders

6. Immunohistology of Lymph Node and Lymph Node Neoplasms

7. Immunohistology of Melanocytic Neoplasms

8. Immunohistology of Metastatic Carcinoma of Unknown Primary Site

9. Immunohistology of Head and Neck Lesions

10. Immunohistology of Endocrine Tumors

11. Immunohistology of the Mediastinum

12. Immunohistology of Lung and Pleural Neoplasms

13. Immunohistology of Skin Tumors

14. Immunohistology of the Gastrointestinal Tract

15. Immunohistology of Pancreas and Hepatobiliary Tract

16. Immunohistology of the Prostate

17. Immunohistology of the Bladder, Kidney, and Testis

18. Immunohistology of the Female Genital Tract

19. Immunohistology of the Breast

20. Immunohistology of the Nervous System

21. Immunocytology

22. Immunohistology of Pediatric Neoplasms

23. Imaging and Quantitative Immunohistochemistry

What People are Saying About This

From the Publisher

Your #1 authoritative guide to the appropriate use of immunohistochemical stains

Editorial Reviews

Reviewer: Anna B Owczarczyk, MD, PHD (University of Michigan Medical School)
Description: This sixth edition is a comprehensive yet concise guide in the use and interpretation of immunohistochemical stains, with each chapter addressing a surgical pathology area by organ system. The last edition was published in 2019.
Purpose: The book's purpose is to serve as a diagnostic and therapeutic reference, with an emphasis on how immunohistochemistry is integrated with clinical, genomic, and pathologic findings.
Audience: The book's audience is quite broad: pathologists, oncologists, trainees, and researchers.
Features: The first two chapters focus on the techniques and development of immunohistochemistry, with up-to-date information regarding standardization and quality assurance. The final chapters address complementary techniques to immunohistochemistry: digital imaging and molecular techniques. The middle portion of the textbook is broken down into organ-specific surgical pathology disciplines and focuses on the role of immunohistochemistry within these fields. Each chapter is written to stand on its own, with minor areas of redundancy noted among chapters. The major organ systems/pathologic areas include infectious disease; soft tissue and bone; bone marrow/spleen/histiocytic lesions; lymph node and lymphomas; melanocytic neoplasms; carcinomas of unknown primary; head and neck; endocrine/neuroendocrine; mediastinum; pulmonary and pleural neoplasms; skin tumors; gastrointestinal tumors; pancreatic and hepatobiliary tract; prostate; bladder/kidney/testis; female genital tract; breast; nervous system; cytology; and pediatric neoplasms. Each chapter systematically addresses the diagnostic entities in its focused organ system, including detailed differential diagnoses, diagnostic algorithms, immunohistograms, and diagnostic pitfalls. The key diagnostic points are highlighted in summary tables after each sub-section. Where applicable, the contributors address any drug (or potential drug) targets and current biomarker guidelines. There are 1,500 quality color histologic images, with a plethora of charts and tables throughout the textbook. While the images are small-to-medium in size, they have great contrast and color, and are accompanied by clear captions. The tables regarding antibody specifications are very thorough, conveying information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
Assessment: This book has grown since the fifth edition to maintain its standing as a comprehensive text. Yet, it remains an exceptionally well-organized, highly relevant, and immensely useful resource for practicing pathologists, oncologists, pathology trainees, and scientists alike.

Doody's Review Service

I found the book not only critically informative, helpful for diagnosticians, and fully updated but formative ... It should be present on the shelf of practicing diagnosticians, … and should also constitute part of the education of young generations

From the Publisher