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Doody ReviewsReviewer: Valerie L. Ng, PhD MD (Alameda County Medical Center/Highland Hospital)
Description: This is the third edition of a comprehensive reference on diagnostic immunohistochemistry. The previous edition was published in 2002.
Purpose: The purpose is to distill the large body of information on immunohistochemistry into a concise, practical, and useful tool for diagnostic surgical pathologists.
Audience: This book is intended for practicing surgical pathologists, and it would be useful for anyone in training (residents, fellows) or interested in how a pathologist uses immunohistochemistry to arrive at diagnoses.
Features: I know a book is useful when the advance copies have vanished from my office before I can even review them. When this book arrived, my colleagues were already fighting amongst themselves as to who would get it after my review was done. After reviewing it (I had to retrieve it from various offices where it had mysteriously "migrated") , I fully understand their excitement and eagerness. This book is arguably THE reference for diagnostic immunohistochemistry. To quote one of my partners, "it has all the tables." Translation: there are multiple tables in this book guiding readers to the correct diagnosis based on specific combinations of immunohistochemistry results. The first two of the book's 21 chapters are introductions to immunohistochemistry staining and molecular anatomic pathology techniques (e.g., FISH, target amplification, DNA sequencing, RFLP, etc.). The remaining chapters are organ specific. Each chapter is intended to stand alone - as a result, there is some unavoidable duplication between chapters. New to this edition are chapter-specific discussions on the therapeutic ("theranostic") applications reliant on various immunohistochemistry tests. While the paradigm is Her2/neu positive immunohistochemistry and therapeutic use of trastuzumab, each chapter is updated with a discussion of the many gene targets against which therapeutic treatments exist or are being developed, and, hence, the relevance of demonstrating target expression in the diseased tissue. This book lives up to the stellar reputation of the previous editions and maintains its preeminent position as THE reference for diagnostic immunohistochemistry.
Assessment: This is a must-have book for busy practicing surgical pathologists. It is practical, concise, and useful in everyday practice.