Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, Expert Consult: Online and Print / Edition 3

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Overview

Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin’s lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today’s indispensable guide to the effective use of immunohistochemical diagnosis.

  • Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
  • Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization.
  • Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors.
  • Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance.
  • Features an expert author for each chapter to ensure coverage of the current state of the art.
  • Includes access to the full text online at expertconsult.com, along with a downloadable image bank and Path Consult.
  • Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches.
  • Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results.
  • Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin’s lymphoma.
  • Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
  • Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms.
  • Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.

Accurately interpret immunohistochemical results and provide the clinician with the best therapeutic approaches for the patient

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

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Editorial Reviews

Doody Reviews
Reviewer: Valerie L. Ng, PhD MD (Alameda County Medical Center/Highland Hospital)
Description: This is the third edition of a comprehensive reference on diagnostic immunohistochemistry. The previous edition was published in 2002.
Purpose: The purpose is to distill the large body of information on immunohistochemistry into a concise, practical, and useful tool for diagnostic surgical pathologists.
Audience: This book is intended for practicing surgical pathologists, and it would be useful for anyone in training (residents, fellows) or interested in how a pathologist uses immunohistochemistry to arrive at diagnoses.
Features: I know a book is useful when the advance copies have vanished from my office before I can even review them. When this book arrived, my colleagues were already fighting amongst themselves as to who would get it after my review was done. After reviewing it (I had to retrieve it from various offices where it had mysteriously "migrated") , I fully understand their excitement and eagerness. This book is arguably THE reference for diagnostic immunohistochemistry. To quote one of my partners, "it has all the tables." Translation: there are multiple tables in this book guiding readers to the correct diagnosis based on specific combinations of immunohistochemistry results. The first two of the book's 21 chapters are introductions to immunohistochemistry staining and molecular anatomic pathology techniques (e.g., FISH, target amplification, DNA sequencing, RFLP, etc.). The remaining chapters are organ specific. Each chapter is intended to stand alone - as a result, there is some unavoidable duplication between chapters. New to this edition are chapter-specific discussions on the therapeutic ("theranostic") applications reliant on various immunohistochemistry tests. While the paradigm is Her2/neu positive immunohistochemistry and therapeutic use of trastuzumab, each chapter is updated with a discussion of the many gene targets against which therapeutic treatments exist or are being developed, and, hence, the relevance of demonstrating target expression in the diseased tissue. This book lives up to the stellar reputation of the previous editions and maintains its preeminent position as THE reference for diagnostic immunohistochemistry.
Assessment: This is a must-have book for busy practicing surgical pathologists. It is practical, concise, and useful in everyday practice.
From The Critics
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is the third edition of a comprehensive reference on diagnostic immunohistochemistry. The previous edition was published in 2002.
Purpose: The purpose is to distill the large body of information on immunohistochemistry into a concise, practical, and useful tool for diagnostic surgical pathologists.
Audience: This book is intended for practicing surgical pathologists, and it would be useful for anyone in training (residents, fellows) or interested in how a pathologist uses immunohistochemistry to arrive at diagnoses.
Features: I know a book is useful when the advance copies have vanished from my office before I can even review them. When this book arrived, my colleagues were already fighting amongst themselves as to who would get it after my review was done. After reviewing it (I had to retrieve it from various offices where it had mysteriously "migrated"), I fully understand their excitement and eagerness. This book is arguably THE reference for diagnostic immunohistochemistry. To quote one of my partners, "it has all the tables." Translation: there are multiple tables in this book guiding readers to the correct diagnosis based on specific combinations of immunohistochemistry results. The first two of the book's 21 chapters are introductions to immunohistochemistry staining and molecular anatomic pathology techniques (e.g., FISH, target amplification, DNA sequencing, RFLP, etc.). The remaining chapters are organ specific. Each chapter is intended to stand alone - as a result, there is some unavoidable duplication between chapters. New to this edition are chapter-specific discussions on the therapeutic ("theranostic") applications reliant on various immunohistochemistry tests. While the paradigm is Her2/neu positive immunohistochemistry and therapeutic use of trastuzumab, each chapter is updated with a discussion of the many gene targets against which therapeutic treatments exist or are being developed, and, hence, the relevance of demonstrating target expression in the diseased tissue. This book lives up to the stellar reputation of the previous editions and maintains its preeminent position as THE reference for diagnostic immunohistochemistry.
Assessment: This is a must-have book for busy practicing surgical pathologists. It is practical, concise, and useful in everyday practice.
From The Critics
Reviewer: Tejashree A Karnik, MBBS (University of Kansas Medical Center)
Description: "Aside from a few chapters dedicated to techniques in immunohistochemistry, the rest of the 23 chapters in this book deal with organ systems. Chapters are very well structured, and the book includes access to an online version. The previous edition was published in 2010. "
Purpose: The purpose is to educate pathologists about the use of immunohistochemistry and theranostics in accurate diagnosis and to be better prepared to help oncologists and their patients with therapy-related decisions.
Audience: It will be useful for residents and practitioners in pathology, as well as interested oncologists.
Features: "In every chapter dedicated to a particular organ system, each tumor-specific antibody is described with a brief explanation about where the antibody binds, including neoplastic or normal cells. The book has lovely tables that list the immunohistochemical profile of all the tumors. For example, in the chapter on renal neoplasms, there are separate tables listing the immunohistochemical profile for all renal tumors along with differential diagnoses. A separate section in each chapter covers theranostic applications for various tumors. Chapters on immunohistochemistry techniques include standardization methods, pitfalls, and troubleshooting artifacts in staining. The book is easy to navigate and read, and the tables make it a great reference source. Also worth mentioning are the many pictures showing various staining patterns, a good aid for visual learning. "
Assessment: This is a great contribution to the field of pathology. The book will be very useful for anyone who wants to know immunohistochemistry and theranostics in detail.
From The Critics
Reviewer: Tejashree A Karnik, MBBS (University of Kansas Medical Center)
Description: "Aside from a few chapters dedicated to techniques in immunohistochemistry, the rest of the 23 chapters in this book deal with organ systems. Chapters are very well structured, and the book includes access to an online version. The previous edition was published in 2010. "
Purpose: The purpose is to educate pathologists about the use of immunohistochemistry and theranostics in accurate diagnosis and to be better prepared to help oncologists and their patients with therapy-related decisions.
Audience: It will be useful for residents and practitioners in pathology, as well as interested oncologists.
Features: "In every chapter dedicated to a particular organ system, each tumor-specific antibody is described with a brief explanation about where the antibody binds, including neoplastic or normal cells. The book has lovely tables that list the immunohistochemical profile of all the tumors. For example, in the chapter on renal neoplasms, there are separate tables listing the immunohistochemical profile for all renal tumors along with differential diagnoses. A separate section in each chapter covers theranostic applications for various tumors. Chapters on immunohistochemistry techniques include standardization methods, pitfalls, and troubleshooting artifacts in staining. The book is easy to navigate and read, and the tables make it a great reference source. Also worth mentioning are the many pictures showing various staining patterns, a good aid for visual learning. "
Assessment: This is a great contribution to the field of pathology. The book will be very useful for anyone who wants to know immunohistochemistry and theranostics in detail.
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Product Details

  • ISBN-13: 9781416057666
  • Publisher: Elsevier Health Sciences
  • Publication date: 2/12/2010
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 960
  • Product dimensions: 8.90 (w) x 11.10 (h) x 1.70 (d)

Table of Contents

1. Techniques of Immunohistochemistry: Principles, Pitfalls and Standardization

2. Molecular Anatomic Pathology: Principles, Technique and Application to Immunohistologic Diagnosis

3. Immunohistology of Infectious Diseases

4. Immunohistology of Neoplasms of Soft Tissue and Bone

5. Immunohistology of Hodgkin Lymphoma

6. Immunohistology of Non-Hodgkin Lymphoma

7. Immunohistology of Melanocytic Neoplasms

8. Immunohistology of Metastatic Carcinoma of Unknown Primary Site

9. Immunohistology of Head and Neck Lesions

10. Immunohistology of Endocrine Tumors

11. Immunohistology of the Mediastinum

12. Immunohistology of Lung and Pleural Neoplasms

13. Immunohistology of Skin Tumors

14. Immunohistology of the Gastrointestinal Tract

15. Immunohistology of the Pancreas and Hepatobiliary Tract

16. Immunohistology of the Prostate

17. Immunohistology of the Urinary Bladder, Kidney, and Testis

18. Immunohistology of the Female Genital Tract

19. Immunohistology of the Breast

20. Immunohistology of the Nervous System

21. Immunocytology

22. Immunohistology of Pediatric Neoplasms

23. Imaging and Quantitative Immunohistochemistry

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