Diagnostic Tests Toolkit

Overview

This new volume in the Toolkit series is designed for clinicians and junior researchers who need to interpret the evidence for the effectiveness of the many diagnostic tests now available. Exceptionally user-friendly, this pocket-sized textbook realizes readers are not experts in diagnostic test interpretation. The authors cover a variety of issues, from how to design diagnostic test studies to understanding the results of diagnostic tests and interpreting the findings for clinical practice and health care ...

See more details below
Paperback
$31.34
BN.com price
(Save 4%)$32.95 List Price
Other sellers (Paperback)
  • All (9) from $24.70   
  • New (7) from $24.70   
  • Used (2) from $31.33   
Diagnostic Tests Toolkit

Available on NOOK devices and apps  
  • NOOK Devices
  • NOOK HD/HD+ Tablet
  • NOOK
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK Study
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
$18.49
BN.com price
(Save 43%)$32.95 List Price

Overview

This new volume in the Toolkit series is designed for clinicians and junior researchers who need to interpret the evidence for the effectiveness of the many diagnostic tests now available. Exceptionally user-friendly, this pocket-sized textbook realizes readers are not experts in diagnostic test interpretation. The authors cover a variety of issues, from how to design diagnostic test studies to understanding the results of diagnostic tests and interpreting the findings for clinical practice and health care policy.

Read More Show Less

Product Details

  • ISBN-13: 9780470657584
  • Publisher: Wiley
  • Publication date: 11/22/2011
  • Series: EBMT-EBM Toolkit Series , #5
  • Edition number: 2
  • Pages: 112
  • Product dimensions: 4.30 (w) x 6.70 (h) x 0.40 (d)

Meet the Author

Matthew Thompson, Oxford Centre for Monitoring and Diagnosis, Department of Primary Care Health Sciences, University of Oxford, UK & Department of Family Medicine, Oregon Health & Science University, Portland, Oregon, USA

Ann Van den Bruel, Department of Primary Care Health Sciences, University of Oxford, UK

Series Editors:
Carl Heneghan, Centre for Evidence Based Medicine, Oxford, UK

Rafael Perera, Department of Primary Care, University of Oxford, UK

Douglas Badenoch, Minervation Ltd, Edinburgh, UK

Read More Show Less

Read an Excerpt

Click to read or download

Read More Show Less

Table of Contents

Acknowledgements, viii

Introduction, ix

Chapter 1 Diagnosis in evidence-based medicine, 1

Diagnosis and screening, 1

Screening, 3

Symptoms, 3

Signs and elicited symptoms, 4

Bedside or point-of-care testing, 4

Laboratory tests, 4

Basic structure of studies of diagnostic tests, 4

Further reading, 5

Chapter 2 Evaluating new diagnostic tests, 6

Technical accuracy (‘Can it work?’), 7

Place in the clinical pathway (‘Where does the test fi t in the existing clinical pathway?’), 9

Ability of the test to diagnose or exclude the target condition (‘Does it work in patients?’), 10

The effect of the test on patient outcomes (‘Are patients better off?’), 12

Cost-effectiveness (‘Is it worth the cost?’), 14

Further reading, 15

Chapter 3 Asking an answerable clinical question, 16

Defining a clinical question for diagnostic tests – PIRT, 16

Further reading, 17

Chapter 4 Finding the evidence: how to get the most from your searching, 18

Combine textwords and thesaurus, 20

Search filters for diagnostic accuracy studies, 20

Further reading, 21

Chapter 5 Selecting relevant studies, 22

Selecting relevant studies, 22

Assessing validity, 23

What is the difference between bias and variability in diagnostic studies?, 23

The ‘ideal’ diagnostic study, 24

Flow charts of patients, 24

Chapter 6 Sources of bias in diagnostic studies, 26

Spectrum bias (also known as selection bias), 26

Verification bias (also called referral or work-up bias), 28

Incorporation bias, 29

Observer (or test review bias) bias, 30

Differential reference bias (double gold standard), 31

What are the effects of the different design-related biases?, 32

Further reading, 33

Chapter 7 Measures of discrimination of diagnostic tests, 34

Two by two tables, 34

Outcome measures, 36

Which measure should you use and why?, 38

The effect of prevalence on predictive values, 40

Effect of time on diagnostic accuracy, 41

Effect of severity of the target condition on diagnostic accuracy, 42

The referral fi lter, 42

Rules of thumb for interpreting likelihood ratios, 44

Further reading, 52

Chapter 8 Using diagnostic information in clinical practice, 53

Validity of data, 54

Problem-solving strategies that clinicians use in diagnosis, 55

Action thresholds versus testing thresholds (‘Will the test change my management?’), 57

Methods for combining test results, 58

Multivariable analyses, 60

How are clinical prediction rules developed?, 62

How to select a prediction rule for clinical practice, 64

Further reading, 65

Chapter 9 Screening tests, 66

What are screening tests?, 66

Different types of screening, 66

Ideal study design for screening tests, 68

Over-diagnosis, 74

Further reading, 74

Chapter 10 Systematic reviews of diagnostic test  accuracy studies, 75

The research question, 75

The literature search, 76

Assess the quality of individual studies included in the review, 79

Summarizing the results of diagnostic studies, 80

Combining data and interpreting meta-analyses of diagnostic studies, 85

Acknowledgements, 88

Further reading, 88

Appendix 1 Evidence-based medicine – a glossary of terms, 90

Appendix 2 Further reading, 96

Books, 96

Useful websites, 96

Useful journal articles, 96

Index, 98

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)