Dietary Supplements: Toxicology and Clinical Pharmacology / Edition 1

Dietary Supplements: Toxicology and Clinical Pharmacology / Edition 1

by Melanie Johns Cupp
     
 

While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a

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Overview

While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a selection of significant nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available, and include such well-known agents as DHEA,

androstenedione and other over-the-counter steroids, coenzyme Q10, fish oil, glucosamine and chondroitin, chitosan, chromium picolinate, creatine, vanadyl sulfate, SAMe, and melatonin. Additional coverage is given to colloidal silver, shark cartilage, germanium, red yeast rice extract, l-tryptophan, N,N-dimethylglycine, GHB and GBL, huperzine, hydrazine, methylsulfonylmethane, and pyruvate. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of their adverse effects and interactions, as well as information on their reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.

Authoritative and objective, Dietary Supplements: Toxicology and Clinical Pharmacology offers physicians, pharmacologists, pharmacists, toxicologists, and medical examiners a treasure trove of uncommon-but reliable-scientific and clinical information on the toxicity and usefulness of today's leading nonherbal dietary supplements.

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Product Details

ISBN-13:
9781588290144
Publisher:
Springer-Verlag New York, LLC
Publication date:
12/28/2002
Series:
Forensic Science and Medicine Series
Edition description:
2003
Pages:
410
Product dimensions:
7.16(w) x 10.40(h) x 1.19(d)

Table of Contents

Part I. Legal/Regulatory Aspects of Dietary Supplements

Chapter 1. Legal/Regulatory Aspects of Dietary Supplements
Melanie Johns Cupp. Summary

Part II. Monographs

Chapter 1. Androstenedione and Other Over-the-Counter Steroids
Jason L. Duncan, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available. Physiologic Role
Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 2. Chitosan
Kimberly Novak, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Animal Data
Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 3. Chromium Picolinate
Aleshia R. Haslacker, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Animal Data
Clinical Studies
Lipid Levels
Body Composition and Strength
Diabetes
Pharmacokinetics
Adverse Effects and Toxicity
Interactions. Reproduction
Biofluid Analysis
Regulatory Status
Summary

Chapter 4. Coenzyme Q10 (Ubiquinone, Ubidecarenone)
Melanie Johns Cupp and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Role
In Vitro Effects and Animal Data
Clinical Studies
Heart Failure
Heart Surgery
Hypertension
Cancer
Doxorubicin-InducedCardiotoxicity
Hyperlipidemia
Diabetes
Exercise Capacity
Myopathies
Periodontal Disease
Photoaging
Sperm Function
Primary Biliary Cirrhosis
Immune Function
Chronic Fatigue Syndrome
Huntington's Disease
Migraine
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 5. Colloidal Silver
Melanie Johns Cupp and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
In Vitro Effects
Clinical Data
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 6. Creatine Monohydrate
Nancy Romanchak, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Role
In Vitro Effects and Animal Data
Clinical Studies
Inborn Errors of Metabolism
Enhancement of Athletic Performance
Cardiovascular Effects
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 7. Dehydroepiandrosterone (DHEA) (Prasterone)
John Edward Pope, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Effects
In Vitro Effects and Animal Data
Clinical Studies
Exercise Performance
Systemic Lupus Erythematosus
Replacement in Aging
Depression
HIV/AIDS
Other Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Bio

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