Dietary Supplements: Toxicology and Clinical Pharmacology / Edition 1

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Overview

A treasure trove of uncommon and reliable scientific and clinical information for the toxicity and usefulness of today's leading nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of adverse effects and interactions, as well as information on reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.

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Editorial Reviews

Doody's Review Service
Reviewer: Cynthia K Aaron, MD, FACMT, FACEP (University of Massachusetts Memorial Medical Center)
Description: This is a well researched compilation of information on some of the major nonherbal dietary supplements being used in the U.S. Each monograph is presented in a logical format, delineating history, chemical composition, physiologic role, kinetics, reproductive and regulatory status with a summary statement. Chemical diagrams are provided for each supplement. This book is unique in the way it uses data from reputable and peer-reviewed sources and attempts to adopt an evidence-based analysis of the supplements.
Purpose: The purpose is to provide objective, comprehensive, and summary information on nonherbal dietary supplements culled from reliable sources. It deviates from most other resources in that the authors use peer-reviewed sources, meta-analyses, systematic reviews, and other high quality reviews from recognized experts. By doing so, it provides the reader with a relatively bias-free objective evaluation of the listed supplements, something that can be very difficult to obtain.
Audience: This book is intended for practicing healthcare clinicians who have patients using these supplements, particularly internists, family practitioners, and emergency physicians. It also has utility for exercise physiologists and other specialists whose patients may be using these supplements for particular ailments or aims. Forensic physicians and researchers will find the information on pharmacokinetics, biofluid analysis and interactions quite useful.
Features: This book covers a number of the more popular nonherbal dietary supplements. Many of these are extensively used by the general public based on claims that may or may not be substantiated. Some of the more topical and controversial agents include DHEA, coenzyme Q10, melatonin, and GHB. The book is nonjudgmental and backs up its assertions with pertinent references and provides data on both positive and negative aspects of each supplement. The summary chart at the end of the book provides a quick reference for the reader. The references are approximately two years old and there may now be newer information available. In addition, the Institute of Medicine is currently collecting data on some of these same topics in an evidence-based fashion to present to the FDA. As I was reading this, I would have liked to have had the companion book on herbal supplements, Toxicology and Clinical Pharmacology of Herbal Products (Humana Press, 2000).
Assessment: This is a useful and enlightening book. It is a nice alternative to the multiple other options on supplements as it uses reliable sources and is scientifically based. Some of the data, such as interactions and pharmacokinetics, is difficult to find without substantial research. It has been nicely collected in this one book.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781588290144
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/28/2002
  • Series: Forensic Science and Medicine Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 410
  • Product dimensions: 7.16 (w) x 10.40 (h) x 1.19 (d)

Table of Contents

Part I. Legal/Regulatory Aspects of Dietary Supplements

Chapter 1. Legal/Regulatory Aspects of Dietary Supplements
Melanie Johns Cupp. Summary

Part II. Monographs

Chapter 1. Androstenedione and Other Over-the-Counter Steroids
Jason L. Duncan, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available. Physiologic Role
Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 2. Chitosan
Kimberly Novak, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Animal Data
Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 3. Chromium Picolinate
Aleshia R. Haslacker, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Animal Data
Clinical Studies
Lipid Levels
Body Composition and Strength
Diabetes
Pharmacokinetics
Adverse Effects and Toxicity
Interactions. Reproduction
Biofluid Analysis
Regulatory Status
Summary

Chapter 4. Coenzyme Q10 (Ubiquinone, Ubidecarenone)
Melanie Johns Cupp and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Role
In Vitro Effects and Animal Data
Clinical Studies
Heart Failure
Heart Surgery
Hypertension
Cancer
Doxorubicin-InducedCardiotoxicity
Hyperlipidemia
Diabetes
Exercise Capacity
Myopathies
Periodontal Disease
Photoaging
Sperm Function
Primary Biliary Cirrhosis
Immune Function
Chronic Fatigue Syndrome
Huntington's Disease
Migraine
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 5. Colloidal Silver
Melanie Johns Cupp and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
In Vitro Effects
Clinical Data
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 6. Creatine Monohydrate
Nancy Romanchak, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Role
In Vitro Effects and Animal Data
Clinical Studies
Inborn Errors of Metabolism
Enhancement of Athletic Performance
Cardiovascular Effects
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Biofluid Analysis
Regulatory Status
Summary

Chapter 7. Dehydroepiandrosterone (DHEA) (Prasterone)
John Edward Pope, Melanie Johns Cupp, and Timothy S. Tracy

History
Chemical Structure
Current Promoted Uses
Sources and Chemical Composition
Products Available
Physiologic Effects
In Vitro Effects and Animal Data
Clinical Studies
Exercise Performance
Systemic Lupus Erythematosus
Replacement in Aging
Depression
HIV/AIDS
Other Clinical Studies
Pharmacokinetics
Adverse Effects and Toxicity
Interactions
Reproduction
Chemical and Bio

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