Dietary Supplements: Toxicology and Clinical Pharmacology

Overview

While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a selection of significant nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of ...
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Overview

While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a selection of significant nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available, and include such well-known agents as DHEA, androstenedione and other over-the-counter steroids, coenzyme Q10, fish oil, glucosamine and chondroitin, chitosan, chromium picolinate, creatine, vanadyl sulfate, SAMe, and melatonin. Additional coverage is given to colloidal silver, shark cartilage, germanium, red yeast rice extract, L-tryptophan, N,N-dimethylglycine, GHB and GBL, huperzine, hydrazine, methylsulfonylmethane, and pyruvate. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of their adverse effects and interactions, as well as information on their reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.

Authoritative and objective, Dietary Supplements: Toxicology and Clinical Pharmacology offers physicians, pharmacologists, pharmacists, toxicologists, and medical examiners a treasure trove of uncommon -- but reliable -- scientific and clinical information on the toxicity and usefulness of today's leading nonherbal dietary supplements.

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Editorial Reviews

Doody's Review Service
Reviewer: Cynthia K Aaron, MD, FACMT, FACEP (University of Massachusetts Memorial Medical Center)
Description: This is a well researched compilation of information on some of the major nonherbal dietary supplements being used in the U.S. Each monograph is presented in a logical format, delineating history, chemical composition, physiologic role, kinetics, reproductive and regulatory status with a summary statement. Chemical diagrams are provided for each supplement. This book is unique in the way it uses data from reputable and peer-reviewed sources and attempts to adopt an evidence-based analysis of the supplements.
Purpose: The purpose is to provide objective, comprehensive, and summary information on nonherbal dietary supplements culled from reliable sources. It deviates from most other resources in that the authors use peer-reviewed sources, meta-analyses, systematic reviews, and other high quality reviews from recognized experts. By doing so, it provides the reader with a relatively bias-free objective evaluation of the listed supplements, something that can be very difficult to obtain.
Audience: This book is intended for practicing healthcare clinicians who have patients using these supplements, particularly internists, family practitioners, and emergency physicians. It also has utility for exercise physiologists and other specialists whose patients may be using these supplements for particular ailments or aims. Forensic physicians and researchers will find the information on pharmacokinetics, biofluid analysis and interactions quite useful.
Features: This book covers a number of the more popular nonherbal dietary supplements. Many of these are extensively used by the general public based on claims that may or may not be substantiated. Some of the more topical and controversial agents include DHEA, coenzyme Q10, melatonin, and GHB. The book is nonjudgmental and backs up its assertions with pertinent references and provides data on both positive and negative aspects of each supplement. The summary chart at the end of the book provides a quick reference for the reader. The references are approximately two years old and there may now be newer information available. In addition, the Institute of Medicine is currently collecting data on some of these same topics in an evidence-based fashion to present to the FDA. As I was reading this, I would have liked to have had the companion book on herbal supplements, Toxicology and Clinical Pharmacology of Herbal Products (Humana Press, 2000).
Assessment: This is a useful and enlightening book. It is a nice alternative to the multiple other options on supplements as it uses reliable sources and is scientifically based. Some of the data, such as interactions and pharmacokinetics, is difficult to find without substantial research. It has been nicely collected in this one book.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781468497267
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/30/2014
  • Series: Forensic Science and Medicine Series
  • Edition description: Softcover reprint of the original 1st ed. 2003
  • Pages: 410
  • Product dimensions: 7.01 (w) x 10.00 (h) x 0.89 (d)

Table of Contents

Preface
Contents of Companion Volume
Pt. I Legal/Regulatory Aspects of Dietary Supplements
Ch. 1 Legal/Regulatory Aspects of Dietary Supplements 3
Pt. II Monographs
Ch. 1 Androstenedione and Other Over-the-Counter Steroids 17
Ch. 2 Chitosan 33
Ch. 3 Chromium Picolinate 41
Ch. 4 Coenzyme Q10 (Ubiquinone, Ubidecarenone) 53
Ch. 5 Colloidal Silver 87
Ch. 6 Creatine Monohydrate 91
Ch. 7 Dehydroepiandrosterone (DHEA) (Prasterone) 123
Ch. 8 Dimethylglycine (N,N-Dimethylglycine) 149
Ch. 9 Fish Oil 161
Ch. 10 [gamma]-Hydroxybutyric Acid (GHB), [gamma]-Butyrolactone (GBL), and 1,4-Butanediol (BD) 173
Ch. 11 Germanium 197
Ch. 12 Glucosamine and Chondroitin 209
Ch. 13 Huperzine 245
Ch. 14 Hydrazine Sulfate 253
Ch. 15 5-Hydroxytryptophan (5-Hydroxy-L-Tryptophan, L-5-Hydroxytryptophan, Oxitriptan) 267
Ch. 16 Melatonin (N-acetyl-5-Methoxytryptamine) 277
Ch. 17 Methylsulfonylmethane (Dimethylsulfone) 297
Ch. 18 Pyruvate 303
Ch. 19 Red Yeast Rice Extract 313
Ch. 20 SAMe (S-adenosyl-L-methionine) 321
Ch. 21 Shark Cartilage 335
Ch. 22 L-Tryptophan 341
Ch. 23 Vanadyl Sulfate 387
Appendix: Summary Table on Dietary Supplements 395
Index 401
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