Discovering Genomics, Proteomics, and Bioinformatics / Edition 1

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Overview

Discovering Genomics, Proteomics, and Bioinformatics combines integrated Web exercises with a problem-solving approach to train readers in basic hands-on genomic analysis. The authors present global problems, then provide the tools of genomic analysis to help readers dissect the answer, thus encouraging critical thinking skills. Short boxed readings called "Math Minutes" explain the math behind the biology. For anyone interested in genomics, proteomics, or bioinformatics.
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Product Details

  • ISBN-13: 9780805347227
  • Publisher: Benjamin Cummings
  • Publication date: 9/13/2002
  • Edition description: BK&CD-ROM
  • Edition number: 1
  • Pages: 352
  • Product dimensions: 8.50 (w) x 10.72 (h) x 0.59 (d)

Table of Contents

Foreword
Preface
Acknowledgments
Unit 1 Genome Sequences 1
Ch. 1 Genome Sequence Acquisition and Analysis 2
1.1 Defining Genomes 3
1.2 What Have We Learned from the Human Genome Draft Sequences? 17
Ch. 2 Genome Sequences Answer Interesting Questions 30
2.1 Evolution of Genomes 31
2.2 Genomic Identifications 46
2.3 Biomedical Genome Research 57
Ch. 3 Genomic Variations 69
3.1 Environmental Case Study 70
3.2 Human Genomic Variation 76
3.3 The Ultimate Genomic Phenotype-Death? 89
3.4 Ethical Consequences of Genomic Variations 93
Unit 2 Genome Expression 105
Ch. 4 Basic Research with DNA Microarrays 106
4.1 Introduction to Microarrays 107
4.2 Alternative Uses of DNA Microarrays 128
Ch. 5 Applied Research with DNA Microarrays 137
5.1 Cancer and Genomic Microarrays 138
5.2 Improving Health Care with DNA Microarrays 146
Ch. 6 Proteomics 161
6.1 Introduction 162
6.2 Protein 3D Structures 171
6.3 Protein Interaction Networks 176
6.4 Measuring Proteins 183
Unit 3 Whole Genome Perspective 205
Ch. 7 Genomic Circuits in Single Genes 206
7.1 Dissecting a Gene's Circuitry 207
7.2 Integrating Single-Gene Circuits 229
Ch. 8 Integrated Genomic Circuits 232
8.1 Simple Integrated Circuits 233
8.2 Complex Integrated Circuits 244
Ch. 9 Modeling Whole-Genome Circuits 265
9.1 Is Genomics a New Perspective? 266
9.2 Can We Model Entire Eukaryotes with a Systems Approach? 267
9.3 Will Systems Biology Go Systemic? 274
Unit 4 Transition from Genetics to Genomics: Medical Case Studies 277
Ch. 10 What's Wrong with My Child? 278
10.1 First Patients 279
10.2 The Next Steps in Understanding the Disease 284
Ch. 11 Why Can't I Just Take a Pill to Lose Weight? 306
Ch. 12 Why Can't We Cure More Diseases? 320
Glossary 331
Credits 341
Index 345
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