Disease Evolution

Disease Evolution

by Zhilan Feng
     
 

ISBN-10: 0821837532

ISBN-13: 9780821837535

Pub. Date: 05/28/2006

Publisher: American Mathematical Society

Infectious diseases are continuing to threaten humankind. While some diseases have been controlled, new diseases are constantly appearing. Others are now reappearing in forms that are resistant to drug treatments. A capacity for continual re-adaptation furnishes pathogens with the power to escape our control efforts through evolution. This makes it imperative to

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Overview

Infectious diseases are continuing to threaten humankind. While some diseases have been controlled, new diseases are constantly appearing. Others are now reappearing in forms that are resistant to drug treatments. A capacity for continual re-adaptation furnishes pathogens with the power to escape our control efforts through evolution. This makes it imperative to understand the complex selection pressures that are shaping and reshaping diseases. Modern models of evolutionary epidemiology provide powerful tools for creating, expressing, and testing such understanding. Bringing together international leaders in the field, this volume offers a panoramic tour of topical developments in understanding the mechanisms of disease evolution. The volume's first part elucidates the general concepts underlying models of disease evolution. Methodological challenges addressed include those posed by spatial structure, stochastic dynamics, disease phases and classes, single- and multi-drug resistance, the heterogeneity of host populations and tissues, and the intricate coupling of disease evolution with between-host and within-host dynamics. The book's second part shows how these methods are utilized for investigating the dynamics and evolution of specific diseases, including HIV/AIDS, tuberculosis, SARS, malaria, and human rhinovirus infections. This volume is particularly suited for introducing young scientists and established researchers with backgrounds in mathematics, computer science, or biology to the current techniques and challenges of mathematical evolutionary epidemiology.

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Product Details

ISBN-13:
9780821837535
Publisher:
American Mathematical Society
Publication date:
05/28/2006
Series:
DIMACS: Series in Discrete Mathematics and Theoretical Computer Science Ser., #71
Edition description:
New Edition
Pages:
237
Product dimensions:
7.30(w) x 10.30(h) x 0.70(d)

Table of Contents

The implications of spatial structure within populations to the evolution of parasites3
Insights from Price's equation into evolutionary epidemiology23
Within-host pathogen dynamics : some ecological and evolutionary consequences of transients, dispersal mode, and within-host spatial heterogeneity45
Evolutionary and dynamic models of infection with internal host structure67
Basic methods for modeling the invasion and spread of contagious diseases87
Modeling the invasion and spread of contagious diseases in heterogeneous populations113
A cophylogenetic perspective on host-pathogen evolution145
The influence of anti-viral drug therapy on the evolution of HIV-1 pathogens161
Do rhinoviruses follow the neutral theory? : the role of cross-immunity in maintaining the diversity of the common cold181
Drug resistance in acute viral infections : rhinovirus as a case study193
Dynamics and control of antibiotic resistance in structured metapopulations213

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