Disorders of Voluntary Muscle [NOOK Book]

Overview

This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal ...
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Disorders of Voluntary Muscle

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Overview

This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.

This seventh edition has been rewritten and redesigned with the needs of the clinician and clinical scientist in mind. It contains up-to-date information on the etiology and pathogenesis of skeletal muscle diseases, including the mitochondrial myopathies, ion channel disorders, muscular dystrophies, and dysimmune myopathies. This volume covers the many recently identified diseases of muscle, and emphasizes the progress made in diagnosis and treatment. As background to the clinical coverage, this new edition also has chapters summarizing advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology. Combining essential new knowledge with the fundamentals of history taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practicing physicians and biomedical scientists concerned with muscle disease.

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Editorial Reviews

From The Critics
Reviewer:Arlene N. Barr, MD(University of Illinois at Chicago College of Medicine)
Description:This book presents the latest information on the etiology, pathogenesis, and clinical description of skeletal muscle disease. Topics include: mitochondrial myopathies, ion channel disorders, muscular dystrophies, congenital myopathies, dysimmune myopathies, toxic myopathies, and neuromuscular junction diseases. The extensive coverage of the scientific basis and methods of investigation is a welcome component. The previous edition was published in 1994.
Purpose:This book is intended to provide an up-to-date reference for the clinical and basic science aspects of the field. Without question, these are invaluable objectives because there has been a rapid expansion in information since the publication of the previous edition. The authors have provided us an outstanding book.
Audience:I agree with the authors that the book will appeal to a wide range of readers. Practicing clinicians in neurology, rheumatology, pediatrics, orthopedics, and physiatry as well as medical students, graduate students, clinical scientists, and basic scientists all should find its contents very useful. The list of contributors reads like a "Who's Who" in this field.
Features:Both clinical and basic science aspects of muscle disease are covered. There are newly described entities as well as updates on well known diseases. The most remarkable feature of this book is the comprehensive coverage of new information combined with the insights from the best thinkers that could be brought together.
Assessment:Hands down, this book is thebest current publication in its category. The seventh edition is well timed to capture the massive increase of information published since the previous edition of 1994.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780511739170
  • Publisher: Cambridge University Press
  • Publication date: 11/17/2010
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 8
  • File size: 45 MB
  • Note: This product may take a few minutes to download.

Table of Contents

List of contributors
Preface to the Seventh Edition
Foreword
Pt. I The Scientific Basis of Muscle Disease 1
1 The structure and function of motor units 3
2 Developmental biology of skeletal muscle 26
3 The molecular and cellular biology of muscle 42
4 The molecular basis of muscle disease 60
5 Mitochondria 80
6 The sarcotubular system 88
7 The extracellular matrix of skeletal muscle 103
8 Aspects of skeletal muscle biochemistry in health and disease 122
9 The neuromuscular junction and neuromuscular transmission 142
10 The pathophysiology of excitation in skeletal muscle 168
11 Animal models of human muscle disease 187
Pt. II Methods of Investigation of Muscle Disease 217
12 Applied physiology of muscle 219
13 Histochemistry and immunocytochemistry of muscle in health and disease 251
14 Muscle pathology on semithin resin sections 283
15 Electron microscopy in the study of normal and diseased muscle 296
16 Magnetic resonance imaging and spectroscopy of muscle 319
Pt. III Description of Muscle Disease 347
17 The examination and investigation of the patient with muscle disease 349
18 The classification of muscle diseases 374
19 Dystrophinopathies 385
20 Limb girdle muscular dystrophies 433
21 Facioscapulohumeral dystrophy 464
22 Distal myopathies 471
23 Emery-Dreifuss dystrophy 488
24 Oculopharyngeal muscular dystrophy 497
25 Congenital muscular dystrophies 503
26 Congenital myopathies 525
27 Myotonic dystrophy 541
28 The metabolic myopathies 560
29 Oxidative phosphorylation diseases of muscle 580
30 Ion channel disorders of muscle 604
31 Inflammatory myopathies 636
32 Myasthenia gravis and myasthenic syndromes: autoimmune and genetic disorders 660
33 Toxic and latrogenic myopathies and neuromuscular transmission disorders 676
34 Painful muscle syndromes 689
Pt. IV The Principles of Management of Muscle Disease 703
35 Genetic counselling in muscle disease 705
36 The principles of treatment, prevention and rehabilitation and perspectives on future therapies 739
Index 755
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