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This seventh edition has been rewritten and redesigned with the needs of the clinician and clinical scientist in mind. It contains up-to-date information on the etiology and pathogenesis of skeletal muscle diseases, including the mitochondrial myopathies, ion channel disorders, muscular dystrophies, and dysimmune myopathies. This volume covers the many recently identified diseases of muscle, and emphasizes the progress made in diagnosis and treatment. As background to the clinical coverage, this new edition also has chapters summarizing advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology. Combining essential new knowledge with the fundamentals of history taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practicing physicians and biomedical scientists concerned with muscle disease.