Disorders of Voluntary Muscle / Edition 7

Disorders of Voluntary Muscle / Edition 7

by George Karpati
     
 

ISBN-10: 0521650623

ISBN-13: 9780521650625

Pub. Date: 09/28/2001

Publisher: Cambridge University Press

"This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant

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Overview

"This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website"--Provided by publisher.

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Product Details

ISBN-13:
9780521650625
Publisher:
Cambridge University Press
Publication date:
09/28/2001
Edition description:
REV
Pages:
790
Product dimensions:
8.62(w) x 10.87(h) x 2.09(d)

Table of Contents

List of contributors
Preface to the Seventh Edition
Foreword
Pt. IThe Scientific Basis of Muscle Disease1
1The structure and function of motor units3
2Developmental biology of skeletal muscle26
3The molecular and cellular biology of muscle42
4The molecular basis of muscle disease60
5Mitochondria80
6The sarcotubular system88
7The extracellular matrix of skeletal muscle103
8Aspects of skeletal muscle biochemistry in health and disease122
9The neuromuscular junction and neuromuscular transmission142
10The pathophysiology of excitation in skeletal muscle168
11Animal models of human muscle disease187
Pt. IIMethods of Investigation of Muscle Disease217
12Applied physiology of muscle219
13Histochemistry and immunocytochemistry of muscle in health and disease251
14Muscle pathology on semithin resin sections283
15Electron microscopy in the study of normal and diseased muscle296
16Magnetic resonance imaging and spectroscopy of muscle319
Pt. IIIDescription of Muscle Disease347
17The examination and investigation of the patient with muscle disease349
18The classification of muscle diseases374
19Dystrophinopathies385
20Limb girdle muscular dystrophies433
21Facioscapulohumeral dystrophy464
22Distal myopathies471
23Emery-Dreifuss dystrophy488
24Oculopharyngeal muscular dystrophy497
25Congenital muscular dystrophies503
26Congenital myopathies525
27Myotonic dystrophy541
28The metabolic myopathies560
29Oxidative phosphorylation diseases of muscle580
30Ion channel disorders of muscle604
31Inflammatory myopathies636
32Myasthenia gravis and myasthenic syndromes: autoimmune and genetic disorders660
33Toxic and latrogenic myopathies and neuromuscular transmission disorders676
34Painful muscle syndromes689
Pt. IVThe Principles of Management of Muscle Disease703
35Genetic counselling in muscle disease705
36The principles of treatment, prevention and rehabilitation and perspectives on future therapies739
Index755

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