Dispersion of Ventricular Repolarization: State of the Art

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This unique book is the first to offer an update of contemporary knowledge of the dispersion of ventricular repolarization (DVR), from basic concepts to the clinical application of recently obtained knowledge. World-renowned scientists and clinicians in the frontline of this research area have authored 20 chapters on a range of relevant issues.

Growing amounts of recent evidence demonstrate that, in addition to other mechanisms already associated with malignant ventricular ...

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Overview

This unique book is the first to offer an update of contemporary knowledge of the dispersion of ventricular repolarization (DVR), from basic concepts to the clinical application of recently obtained knowledge. World-renowned scientists and clinicians in the frontline of this research area have authored 20 chapters on a range of relevant issues.

Growing amounts of recent evidence demonstrate that, in addition to other mechanisms already associated with malignant ventricular arrhythmias, ventricular myocardial cellular repolarization and DVR should be considered as key factors in these arrhythmias, which are a major cause of death in patients with different types of cardiac disease. This understanding has directly impacted clinical practice by creating a platform for development of new treatment concepts.

This book will interest Cardiologists, Electrophysiologists, and Basic and Clinical Pharmacologists, and other clinicians interested in learning more about the subject.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Booknews
Reviews knowledge and recent research in the dispersion of ventricular repolarization (DVR), from basic concepts to clinical applications. Examines methodological aspects, and DVR and ventricular arrhythmias, cardiac disorders, and antiarrhythmic treatment. Some specific subjects are electrical heterogeneity and the development of arrhythmias, QT dispersion, automatic detection of spatial and temporal heterogeneity of repolarization, the role of ischemia on dispersion of repolarization, and effects of Class I and Class III drugs and of defibrillation. Of interest to cardiologists, electrophysiologists, and basic and clinical pharmacologists. Olsson teaches cardiology at University Hospital, Sweden. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780879934583
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 8/28/2000
  • Edition description: Illustrations: 93
  • Edition number: 1
  • Pages: 330
  • Product dimensions: 6.34 (w) x 9.33 (h) x 1.14 (d)

Table of Contents

Preface
1 Electrical Heterogeneity and the Development of Arrhythmias 3
2 Repolarization Inhomogeneities in Ventricular Myocardium: Studies Using the Optical Mapping Technique 23
3 QT Dispersion: Methodology and Clinical Significance 41
4 QT Dispersion on 12-Lead Electrocardiogram in Normal Subjects: Reproducibility and Relation to T Wave 59
5 Correlations Between Monophasic Action Potential Recordings and Surface Electrocardiograms with Regard to the Evaluation of Dispersion of Ventricular Repolarization 75
6 Automatic Detection of Spatial and Temporal Heterogeneity of Repolarization 85
7 Evaluation of Ventricular Activation-Recovery Coupling Using an Electroanatomical Mapping Technique 109
8 Global Dispersion of Ventricular Repolarization: Findings from Monophasic Action Potential Mapping Using the CARTO System 121
9 Increased Dispersion of Repolarization: A Major Mechanism Behind the Genesis of Malignant Ventricular Arrhythmias in Cardiac Diseases 143
10 Dispersion of "Refractoriness" and Ventricular Tachycardia or Fibrillation After Myocardial Infarction 165
11 The Electrophysiological Mechanism of Torsade de Pointes in the Long QT Syndrome 175
12 Spatial Dispersion of Ventricular Repolarization in the Long QT Syndrome 199
13 Role of Ischemia on Dispersion of Repolarization 211
14 Dispersion of Repolarization in Patients with Dilated Cardiomyopathy 229
15 Dispersion of Repolarization in Patients with Hypertension 239
16 QT Dispersion in Patients with Congestive Heart Failure and Ventricular Arrhythmias 253
17 Modulation of Dispersion of Ventricular Repolarization by Antiarrhythmic Drugs 267
18 Effect of Class I Drugs on Dispersion of Repolarization 279
19 Effect of Class III Drugs on Dispersion of Repolarization in Patients with Myocardial Infarction 289
20 Effect of Defibrillation on Dispersion of Repolarization 297
Index 319
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