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Doody's Review ServiceReviewer: Stephen Vogel(University of Illinois at Chicago College of Medicine)
Description: This Volume 117 in the Handbook of Experimental Pharmacology series (2nd edition) is on the pharmacologic mechanisms of diuretics in clinical use. Background information on renal function is provided in chapters 1, 2, and 3. Chapter 4 gives a historical perspective on the modern diuretic agents. Chapter 5 outlines the metabolism of the clinically important diuretic agents. Chapters 6 through 12 delve into the effects of the diuretics on ion transport in the nephron. The last chapter analyzes the clinical uses of the diuretic agents.
Purpose: The purpose of this volume is to provide a comprehensive update on the basic pharmacologic mechanisms of the diuretic agents.
Audience: The primary audience will be basic scientists and students in the field of pharmacology. This volume should also be of interest to clinicians in the field of nephrology, especially those engaged in basic or applied scientific research.
Features: Illustrations are in black and white. Photomicrographs are exceptionally crisp and nicely labeled. Figure legends are generally concise and readable.
Assessment: This book is of extremely high quality. The editors and contributors are internationally respected investigators. The resulting volume should be a useful reference for clinicians and basic scientists. This book is recommended particularly for purchase by university libraries. Individuals should be able to order a personal copy. This edition incorporates a tremendous amount of information on the clinical aspects and molecular mechanisms of diuretics, accumulated in the 25-year period since the appearance of the first edition.