Diuretics

Overview

This volume deals with the mechanisms of action of diuretics including cellular mechanisms of action, pharmacokinetics, and clinical usage. A major part focusses on most recent findings on the pharmacodynamics of the respective drugs. During the past twenty-five years since volume 14 on Diuretica was published in the Handbook series, the cellular mechanisms of action of diuretics have been unravelled. Today, the role of action within the target cells is known for most of the substances discussed. This has ...

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517 pp., Hardcover, ex library, else text clean and binding tight

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Hardcover Good 3540589651 Good; Hardcover; 1996, Springer Publishing; Former library copy with standard library markings; Light wear to covers with "straight" edge-corners; ... Paperclip mark to one page; Pages slightly age-toned, otherwise unmarked; Good binding with straight spine; Dark blue cloth with title in orange lettering; 517 pages; "Diuretics (Handbook of Experimental Pharmacology), " by Greger, Knauf, and Mutschler. Read more Show Less

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Overview

This volume deals with the mechanisms of action of diuretics including cellular mechanisms of action, pharmacokinetics, and clinical usage. A major part focusses on most recent findings on the pharmacodynamics of the respective drugs. During the past twenty-five years since volume 14 on Diuretica was published in the Handbook series, the cellular mechanisms of action of diuretics have been unravelled. Today, the role of action within the target cells is known for most of the substances discussed. This has provided a new basis not only for the understanding of drug action but also for secondary effects and interactions. The book is a comprehensive reference work on the diverse groups of diuretics which are among the most frequently prescribed medications.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Stephen Vogel(University of Illinois at Chicago College of Medicine)
Description: This Volume 117 in the Handbook of Experimental Pharmacology series (2nd edition) is on the pharmacologic mechanisms of diuretics in clinical use. Background information on renal function is provided in chapters 1, 2, and 3. Chapter 4 gives a historical perspective on the modern diuretic agents. Chapter 5 outlines the metabolism of the clinically important diuretic agents. Chapters 6 through 12 delve into the effects of the diuretics on ion transport in the nephron. The last chapter analyzes the clinical uses of the diuretic agents.
Purpose: The purpose of this volume is to provide a comprehensive update on the basic pharmacologic mechanisms of the diuretic agents.
Audience: The primary audience will be basic scientists and students in the field of pharmacology. This volume should also be of interest to clinicians in the field of nephrology, especially those engaged in basic or applied scientific research.
Features: Illustrations are in black and white. Photomicrographs are exceptionally crisp and nicely labeled. Figure legends are generally concise and readable.
Assessment: This book is of extremely high quality. The editors and contributors are internationally respected investigators. The resulting volume should be a useful reference for clinicians and basic scientists. This book is recommended particularly for purchase by university libraries. Individuals should be able to order a personal copy. This edition incorporates a tremendous amount of information on the clinical aspects and molecular mechanisms of diuretics, accumulated in the 25-year period since the appearance of the first edition.
Stephen Vogel
This Volume 117 in the Handbook of Experimental Pharmacology series (2nd edition) is on the pharmacologic mechanisms of diuretics in clinical use. Background information on renal function is provided in chapters 1, 2, and 3. Chapter 4 gives a historical perspective on the modern diuretic agents. Chapter 5 outlines the metabolism of the clinically important diuretic agents. Chapters 6 through 12 delve into the effects of the diuretics on ion transport in the nephron. The last chapter analyzes the clinical uses of the diuretic agents. The purpose of this volume is to provide a comprehensive update on the basic pharmacologic mechanisms of the diuretic agents. The primary audience will be basic scientists and students in the field of pharmacology. This volume should also be of interest to clinicians in the field of nephrology, especially those engaged in basic or applied scientific research. Illustrations are in black and white. Photomicrographs are exceptionally crisp and nicely labeled. Figure legends are generally concise and readable. This book is of extremely high quality. The editors and contributors are internationally respected investigators. The resulting volume should be a useful reference for clinicians and basic scientists. This book is recommended particularly for purchase by university libraries. Individuals should be able to order a personal copy. This edition incorporates a tremendous amount of information on the clinical aspects and molecular mechanisms of diuretics, accumulated in the 25-year period since the appearance of the first edition.

3 Stars from Doody
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Product Details

Table of Contents

Ch. 1 Functional Anatomy of the Kidney 1
Ch. 2 Basic Concepts of Renal Physiology 67
Ch. 3 Renal Energy Metabolism 115
Ch. 4 Discovery and Development of Diuretic Agents 141
Ch. 5 Metabolism of Diuretics 173
Ch. 6 Interaction of Diuretics with Transport Systems in the Proximal Renal Tubule 201
Ch. 7 Loop Diuretics 221
Ch. 8 Thiazide Diuretics 275
Ch. 9 Potassium-Retaining Diuretics: Aldosterone Antagonists 335
Ch. 10 Potassium-Retaining Diuretics: Amiloride 363
Ch. 11 Potassium-Retaining Diuretics: Triamterene 395
Ch. 12 Osmotic Diuretics: Mannitol 423
Ch. 13 Clinical Uses of Diuretics 443
Subject Index 507
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