Diversified Approach To The Mathematical And Computational Modeling Of Biological Systems.

Overview

Mathematical and computational modeling approaches were applied to the study of four biological systems, each corresponding to a specific length scale. The four systems investigated were: (i) Molecular scale: The Fc/FcRn protein binding interaction, (ii) Cellular scale: The transferrin trafficking pathway, (iii) Multicellular scale: The prostate epithelium, and (iv) Whole-body scale: The regulation of iron uptake. i. Molecular scale. Since the binding of Fc to the neonatal Fc receptor, FcRn, is responsible for ...
See more details below
Other sellers (Paperback)
  • All (2) from $71.81   
  • New (2) from $71.81   
Sending request ...

More About This Book

Overview

Mathematical and computational modeling approaches were applied to the study of four biological systems, each corresponding to a specific length scale. The four systems investigated were: (i) Molecular scale: The Fc/FcRn protein binding interaction, (ii) Cellular scale: The transferrin trafficking pathway, (iii) Multicellular scale: The prostate epithelium, and (iv) Whole-body scale: The regulation of iron uptake. i. Molecular scale. Since the binding of Fc to the neonatal Fc receptor, FcRn, is responsible for the long half-life of IgG, one approach to extend the half-lives of therapeutic antibodies involves optimizing this interaction. To identify Fc mutations which could increase its affinity for FcRn, a computer program was developed which predicted the effects of Fc mutations on FcRn binding affinity. The program successfully recapitulated qualitative trends in the experimental binding of Fc mutants to FcRn. ii. Cellular scale. Transferrin has been used to target therapeutics to tumors, since the transferrin receptor is overexpressed in cancers. To improve transferrin drug carrier efficacy, a mathematical model of the transferrin intracellular trafficking pathway was formulated. The model predicted that lowering the iron release rate of transferrin would increase cellular association and probability of delivering a drug, which was subsequently verified with in vitro trafficking and cytotoxicity experiments. iii. Multicellular scale. Experimental studies suggest that cell movement may play a part in homeostasis of the prostate epithelium, and certain genes frequently altered in prostate cancer are known to regulate cell movement. To investigate the role of prostate cell movement, an agent-based model of the prostate epithelium was established. Simulations of cell movement behaviors within a three-dimensional reconstruction of a prostate duct were evaluated against experimental observations. iv. Whole-body scale. To highlight the importance of recent findings in the study of iron homestasis, and to clarify the role of recent findings in the study of iron homeostasis in the context of an overall model of iron regulation, a compartmental model of iron homeostasis was developed. It was shown that the characteristics of hereditary hemochromatosis could be reproduced by altering the values of molecular parameters in a fashion consistent with the effects of mutations in the HFE gene.
Read More Show Less

Product Details

  • ISBN-13: 9781243646668
  • Publisher: BiblioLabsII
  • Publication date: 9/6/2011
  • Pages: 64
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.13 (d)

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)