DNA Topoisomerases in Cancer

DNA Topoisomerases in Cancer

by Milan Potmesil, Leroy F. Liu, Franco M. Muggia, Robert Silber, Kurt Kohn
     
 

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell

Overview

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Product Details

ISBN-13:
9780195061062
Publisher:
Oxford University Press, USA
Publication date:
08/22/1991
Pages:
354
Product dimensions:
6.25(w) x 9.56(h) x 0.94(d)

Meet the Author

New York University School of Medicine

National Cancer Institute

The Johns Hopkins School of Medicine

Comprehensive Cancer Center, Los Angeles

James Brown Cancer Center, University of Louisville

New York University School of Medicine

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