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Doody's Review ServiceReviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: This new edition gives an overview of the rapid developments that have occurred in vaccine development in the seven years since the first edition. It is packed with technical and scientific information that will be helpful to scientists working on vaccines.
Purpose: In the seven years since the first edition, there have been extraordinary strides in the understanding and application of DNA vaccines. The primary purpose of this new version is to review these developments. This book shows the promise and problems associated with this new technology.
Audience: It is written for researchers in the field of vaccine development and those delving into the production of these vaccines. However, it is written clearly and is easy to follow even for a novice in the field of vaccinology. The research presented is exciting and is offered with clear explanations and rationale. The authors of the chapters clearly know their fields of investigation.
Features: This comprehensive reference takes the process of DNA vaccines from the discovery phase through the production phase. It organizes the various steps in the process into five separate sections. The first section gives several different examples of how DNA vaccines are designed. The second section reviews the techniques used to deliver the vaccines. This is followed by a section that covers the adjuvants used and the theories behind how these adjuvants enhance the activity of the vaccine. The fourth section discusses the applications for DNA vaccines and the final section reviews the production, purification, and quality of DNA vaccine production. This well organized book takes the reader from the conception of the vaccine to the production of the vaccine. It includes a treasure trove of hints, information, and procedures that would be difficult to acquire elsewhere. This is clearly the cookbook that should be used for developing DNA based vaccines.
Assessment: This book contains specific methods for the development of DNA vaccines, includes tips and ideas that have worked in various systems, and describes interesting new ideas as well as the regulatory process required for vaccine development. This book should be a staple in the library of laboratories working in this field.