DNA Vaccines / Edition 1

DNA Vaccines / Edition 1

by Mark W. Saltzman
     
 

This volume reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current applications, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Biology series, these chapters contain detailed practical procedures on the latest in DNA vaccine

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Overview

This volume reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current applications, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Biology series, these chapters contain detailed practical procedures on the latest in DNA vaccine technology.

Product Details

ISBN-13:
9781617375965
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/10/2010
Series:
Methods in Molecular Medicine Series, #127
Edition description:
Softcover reprint of hardcover 1st ed. 2006
Pages:
384
Product dimensions:
0.89(w) x 6.00(h) x 9.00(d)

Meet the Author

Table of Contents

Part 1: DNA Vaccine Design

DNA Vaccine Design
Janet Brandsma

Design of Plasmid DNA Constructs for Vaccines
Donna L. Montgomery and Kristala Jones-Prather

Vaccination with Messenger RNA
Steve Pascolo

A Stress Protein-Facilitated Antigen Expression System for Plasmid DNA Vaccines
Petra Riedl, Nicolas Fissolo, Joerg Reimann, and Reinhold Schirmbeck

In Vitro Assay of Immunostimulatory Activities of Plasmid Vectors
Weiwen Jiang, Charles Rich, and David Pisetsky

Part 2: DNA Vaccine Delivery Systems

Delivery of DNA Vaccines Using Electroporation
Shawn Babiuk, Sylvia van Drunen Little-van den Hurk, and Lorne Babiuk

Needle-Free Injection of DNA Vaccines
Kanakatte Raviprakash and Kevin Porter

Needle-Free Delivery of Veterinary DNA Vaccines
Sylvia van Drunen Little-van den Hurk, Shawn Babiuk, and Lorne Babiuk

Surface-Modified Biodegradable Microspheres for DNA Vaccine Delivery
Mark Keegan and Mark Saltzman

A Dendrimer-Like DNA-Based Vector for DNA Delivery: A Viral and Non-Viral Hybrid Approach
Dan Luo, Yougen Li, Soong Ho Um, and Yen Cu

Identification of Compartments Involved in Mammalian Subcellular Trafficking Pathways by Indirect Immunofluorescence
Anne Doody and David Putnam

Part 3: DNA Vaccine Adjuvants and Activity Enhancement

Adjuvant Properties of CpG Oligonucleotides in Primates
Daniela Verthelyi

Complexes of DNA Vaccines with Cationic, Antigenic Peptides are Potent, Polyvalent CD8+ T Cell-Stimulating Agents
Petra Riedl, Joerg Reimann, and Reinhold Schirmbeck

Prime Boost Strategies in DNA Vaccines
C. Jane Dale, Scott Thomson, Robert De Rose, Charani Ranasinghe, C. Jill Medveczky, Joko Pamungkas, David B. Boyle, Ian A. Ramshaw, and Stephen J. Kent

Modifying Professional Antigen Presenting Cells to Enhance DNA Vaccine Potency
C.-F. Hung, M. Yang, and T.C. Wu

Replicase-Based DNA Vaccines for Allergy Treatment
Sandra Scheiblhofer, Richard Weiss, Maximilian Gabler, Wolfgang Leitner, and Josef Thalhamer

Part 4: DNA Vaccine Applications

Immunological Responses of Neonates and Infants to DNA Vaccines
Martha Sedegah and Stephen L. Hoffman

DNA Vaccines for Allergy Treatment
Richard Weiss, Sandra Scheiblhofer, and Josef Thalhamer

Protection From Autoimmunity by DNA Vaccination Against T Cell Receptor (TCR)
Thorsten Buch and Ari Waisman

Use of Bone Marrow-Chimeric Mice in Elucidating Immune Mechanisms
Akiko Iwasaki

Part 5: DNA Vaccine Production, Purification, and Quality

A Simple Method for the Production of Plasmid DNA in Bioreactors
K. Listner, L. Kiser Bentley, and Michael Chartrain

Practical Methods for Supercoiled pDNA Production
John Ballantyne

Production of Plasmid DNA in Industrial Quantities According to cGMP Guidelines
Joachim Schorr, Peter Moritz, Astrid Breul, and Martin Scheef

Large-Scale Non-Chromatographic Purification of Plasmid DNA
Jason Murphy and Sangeetha Sagar

Assuring the Quality, Safety and Efficacy of DNA Vaccines
James S. Robertson

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