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The Dog and Its Genome
     

The Dog and Its Genome

by Urs Giger, Kerstin Lindblad-Toh, Elaine A. Ostrander
 

ISBN-10: 0879697423

ISBN-13: 9780879697426

Pub. Date: 12/01/2005

Publisher: Cold Spring Harbor Laboratory Press


Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twentyfive chapters written by experts

Overview


Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twentyfive chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

Product Details

ISBN-13:
9780879697426
Publisher:
Cold Spring Harbor Laboratory Press
Publication date:
12/01/2005
Series:
Cold Spring Harbor Monograph Series
Edition description:
REV
Pages:
608
Product dimensions:
6.30(w) x 9.30(h) x 1.30(d)

Table of Contents


BREED CLUBS AND CANINE HISTORY
Working Dogs: History and Applications
The Kennel Club and the Early History of Dog Shows and Breed Clubs
American Breed Clubs and Health Initiatives
BREED CHARACTERISTICS AND MORPHOLOGY
Morphological Variation in the Dog
Genetic Analysis of the Canid Skeleton: Morphological Loci in the Portuguese Water Dog Population
Morphology and Behavior: Are They Coupled at the Genome Level?

CANINE ORIGINS
From Wild Wolf to Domestic Dog
mDNA Studies of the Origin of Dogs
Understanding Genetic Relationships among Purebred Dogs: The PhyDo Project

GENOMICS AND GENOME ORGANIZATION
Karyotype and Chromosomal Organization
The Dog Genome: Sequence, Evolution, and Haplotype Structure
SINEs of Canine Genomic Diversity
The Dog Olfactory and Vomeronasal Receptor Repertoires
The Canine Major Histocompatibility Complex

GENETIC DISEASE AND GENE MAPPING
Breed-specific Hereditary Diseases and Genetic Screening
Models, Mutants, and Man: Searching for Unique Phenotypes and Genes in the Dog Model of Inherited Retinal Degeneration
Copper Toxicosis in Bedlington Terriers
Cystinuria
Molecular Genetics of Dilated Cardiomyopathy
Sex Chromosomes, Sexual Development, and Sex Reversal in the Dog
QTL Mapping Using Crossbreed Pedigrees: Strategies for Canine Hip Dysplasia

CANCER
Breed-specific Canine Lymphoproliferative Diseases
Cancer Biology in Dogs

GENE THERAPY
Gene Therapy for Metabolic Inherited Diseases in Dogs

BEHAVIOR
Behavioral Genetics of Dog Cognition: Human-like Social Skills in Dogs Are Heritable and Derived
The Genetics of Domesticated Behavior in Canids: What Can Dogs and Silver Foxes Tell Us about Each Other?
Appendix
Index

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