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Dopamine Transporters: Chemistry, Biology, and Pharmacology / Edition 1

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Overview

Understanding the dopamine transporter can lead to new therapies for neurological disorders

This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.

This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology:

  • Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization
  • Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers
  • Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods
This is a hands-on reference for researchers, medicinal chemists, pharmacologists, and biologists working with DAT or related proteins and for students in related areas of study.
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Editorial Reviews

From the Publisher
"Much of what will be accomplished in the coming years will require an understanding of the issues and tools presented here. No doubt, those focused on other synaptic transporters will be jealous of this resource and should demand companion volumes." (The Quarterly Review of Biology, March 2010)

"The book is well written and the chapters are well illustrated where appropriate. It is a valuable addition to the bookshelf of anyone interested in dopaminergic neurotransmission." (Journal of Medicinal Chemistry, March 2009)

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Product Details

Meet the Author

Mark L. Trudell, PHD, is University Research Professor of Chemistry at the University of New Orleans. He has authored over ninety published papers, holds three patents, and has overseen more than $6 million in research grants.

Sari Izenwasser, PHD, is Professor in the Department of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine. She is author of three book chapters and over ninety peer-reviewed articles, and has overseen more than $7 million in research grants.

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Table of Contents

Contributors.

Preface.

Part I: Biochemistry and Molecular Biology.

Chapter 1: The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino).

Chapter 2: Dopamine Transporter, Disease States and Pathology (Deborah C. Mash).

Chapter 3: Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh).

Chapter 4: Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan).

Chapter 5: Electrochemical Characterization of Dopamine Transporters (Evgeny A. Budygin and Sara R. Jones).

Part II: Medicinal Chemistry.

Chapter 6: Tropane-Based Dopamine Transporter-uptake Inhibitors (Scott P. Runyon and F. Ivy Carroll).

Chapter 7: The Benztropines: Atypical Dopamine-Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (Amy Hauck Newman and Jonathan L. Katz).

Chapter 8. Structure-Activity Relationship of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice).

Chapter 9: Structure-Activity Relationship Study of Piperidine Derivatives for Dopamine Transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta).

Chapter 10: Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors (Peter C. Meltzer).

Chapter 11: Dopamine-Releasing Agents (Bruce E. Blough).

Part III: Pharmacology.

Chapter 12: PET/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter. (Paul Cumming, Weiguo Ye, Dean F. Wong).

Chapter 13: In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser).

Chapter 14: In Vivo Studies of Dopamine Transporter Function (Jane B. Acri).

Index.

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