Drug Actions and Interactions / Edition 1

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The quick reference guide you need to avoid harmful interactions between prescription drugs, over-the-counter medications, and dietary supplements


"This will serve as an invaluable guide for various medical professionals and basic scientists, as well as pharmacology students with an interest in understanding the relevance of drug interactions to pharmacotherapy....The book is extremely useful as a quick yet thorough guide through the wealth of information that exists for the most common drug therapies....this is unique in its careful consideration of the relevance of dietary supplements to the discussion of drug interactions."—Doody's Review Service

Drug Actions and Interactions is a handy easy-to-access guide to understanding what major drugs are available for specific diseases, how selected drugs produce therapeutic benefits, side effects that may occur when taking these drugs, and which drugs and supplements should not be taken in combination with each other.

Applying the 300 most often prescribed drugs in the United States to more than 80 common disorders, Drug Actions and Interactions discusses each drug’s mechanism of action, side effects, and interactions with other drugs. Molecular structures of medications are also included to help you understand their mechanisms of action. Coverage includes drugs that act on the major systems (cardiovascular, respiratory, gastrointestinal, genitourinary, endocrine, neuronal); bone, muscle, skin, and joints; and general health.

You will also find an appendix listing major drugs currently in use in each therapeutic classification. Thirty-two additional appendices detail interaction between a therapeutic group of drugs and an individual drug or group of drugs, such as interactions of beta-blockers, alpha-blockers, calcium-blockers, etc.

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Editorial Reviews

Doody's Review Service
Reviewer: Rachel R Chennault, PhD (American College of Clinical Pharmacy)
Description: This is a comprehensive guide through the mechanisms of action of major drugs, including prescription medications, over-the-counter drugs, vitamins, and herbal remedies, as well as their potential for interactions when taken in combination.
Purpose: As an increasing number of adults in the United States describe taking multiple medications simultaneously, the potential for dangerous interactions among concomitant drug therapies also rises. This book addresses this important concern by reviewing the top 300 most prescribed drugs in the United States available to treat more than 80 different diseases or conditions, providing an in-depth description of the drugs' mechanisms of action, discussing side effects and adverse drug events associated with each drug's use, and warnings about a drug's potential interactions with a given medication, therapeutic group, and/or dietary supplement to avoid potentially serious consequences of drug-drug interactions.
Audience: This will serve as an invaluable guide for various medical professionals and basic scientists, as well as pharmacology students with an interest in understanding the relevance of drug interactions to pharmacotherapy. As a widely recognized expert and acclaimed author in the field of pharmacology, Dr. Choe lends authority to this discussion.
Features: The book is organized into eight parts based on body systems (i.e., gastrointestinal, endocrine, neuronal, etc.). Chapters in each of these parts address various disease states relevant to the body system and systematically describe the most commonly prescribed drugs for treating each disease or condition, their mechanisms of action, as well as side effects and the biological basis for interaction with other drugs. The appendixes group these major drugs by therapeutic classification and further describe interactions that are shared among each group's members with other groups or individual drug agents.
Assessment: The book is extremely useful as a quick yet thorough guide through the wealth of information that exists for the most common drug therapies. Although readers may find expanded coverage of much of the same material in other books, such as Clinical Drug Data, 11th edition, Smith et al. (McGraw-Hill, 2010), this one is unique in its careful consideration of the relevance of dietary supplements to the discussion of drug interactions.
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Product Details

  • ISBN-13: 9780071634755
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 3/7/2011
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 768
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.20 (d)

Meet the Author

Author Profile

Jae Y. Choe, PhD

American University of the Caribbean

Professor of Pharmacology

School of Medicine

St. Maarten, West Indies

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Table of Contents


About the Author



Common Abbreviations Used in This Book


Part I. Drugs Acting on the Cardiovascular System

1. Hypertension

2. Edema

3. Congestive Heart Failure

4. Cardiac Arrhythmia

5. Angina Pectoris

6. Thrombosis/Myocardial Infarction

7. Hemorrhage

8. Anemia

9. Varicose Veins

10. Hyperlipidemia

Part II. Drugs Acting on the Respiratory System

11. Rhinitis /Sinusitis

12. Laryngitis/Bronchitis

13. Hiccups

14. Tussis (Common Cough)

15. Asthma

Part III. Drugs Acting on the Gastrointestinal System

16. Xerostomia (Dry Mouth)

17. Aphthous Ulcer (Canker Sore)

18. Odontalgia (Toothache)

19. Gingivitis (Gum Infections)

20. Nausea/Vomiting

21. Flatulence

22. Peptic Ulcer

23. Gastroesophageal Reflux Disease (GERD)

24. Dyspepsia

25. Irritable Bowel Syndrome

26. Intestinal Cramps

27. Constipation

28. Diarrhea

29. Hemorrhoids

Part IV. Drugs Acting on the Genitourinary System

30. Erectile Dysfunction (Impotence)

31. Condylomata (Genital Warts)

32. Benign Prostate Hypertrophy

33. Urinary Incontinence

34. Nephrolithiasis (Kidney Stone)

35. Cystitis /Urethritis

36. Urinary Retention

Part V. Drugs Acting on the Bones, Muscles, and Joints

37. Osteoporosis

38. Osteoarthritis/Osteoarthrosis

39. Gout

40. Myasthenia Gravis

41. Muscle Spasticity

42. Carpal Tunnel Syndrome

43. Rosacea

44. Eczema

45. Psoriasis

Part VI. Drugs Acting on the Neuronal System

46. Stress/Anxiety

47. Seasonal Affective Disorder

48. Attention Deficit Hyperactivity Disorder

49. Chronic Fatigue Syndrome

50. Mental Depression

51. Mania

52. Psychosis

53. Alzheimer Disease

54. Memory Impairment

55. Epilepsy

56. Parkinson Disease

57. Vertigo

58. Motion-Sickness

59. Multiple Sclerosis

Part VII. Drugs Acting on the Endocrine System

60. Diabetes Mellitus

61. Diabetes Insipidus

62. Addison Disease

63. Cushing Disease

64. Hyperthyroidism

65. Hypothyroidism

66. Hypogonadism/Infertility

67. Menstrual Dysfunction

68. Menopausal Symptoms

69. Breast Engorgement

70. Hyperemesis Gravidarum

Part VIII. Drugs Acting on General Health

71. Algesia (Physical Pain))

72. Pyrexia (Fever)

73. Insomnia

74. Pregnancy

75: Allergic Reactions

76. Obesity

77. Cancers

78. Systemic Infections by Viruses

79. Systemic Infections by Bacteria

80. Systemic Infections by Fungi

81. Malaria

82. Dysentery

83. Helminthiasis

84. Chemical Poisoning


Appendix A: Major Drugs in Therapeutic Classifications

Appendix B-1: Interactions of Beta-Blockers

Appendix B-2: Interactions of Alpha-Blockers

Appendix B-3: Interactions of ACE Inhibitors

Appendix B-4: Interactions of Thiazide Diuretics

Appendix B-5: Interactions of Loop Diuretics

Appendix B-6: Interactions of Angiotensin-Receptor Blockers

Appendix B-7: Interactions of Calcium Channel-Blockers

Appendix B-8: Interactions of Alpha-Agonists

Appendix B-9: Interactions of Protease Inhibitors

Appendix B-10: Interactions of Antihistamines, First-Generation

Appendix B-11: Interactions of: Antihistamines, Second- Generation

Appendix B-12: Interactions of Atypical Antipsychotic Drugs

Appendix B-13: Interactions of Macrolide Antibiotics

Appendix B-14: Interactions of Antifungal Drugs

Appendix B-15: Interactions of Belladonna Alkaloids

Appendix B-16: Interactions of Benzodiazepines

Appendix B-17: Interactions of Cephalosporins

Appendix B-18: Interactions of Gastric Antacids

Appendix B-19: Interactions of Magnesium Salts

Appendix B-20: Interactions of Glucocorticoids

Appendix B-21: Interactions of H-2 Blockers

Appendix B-22: Interactions of NSAIDs

Appendix B-23: Interactions of Dopamine Agonists

Appendix B-24: Interactions of Penicillins

Appendix B-25: Interactions of Phenothiazine Antipsychotic Drugs

Appendix B-26: Interactions of Progesterone or Progestogens

Appendix B-27: Interactions of Proton Pump Inhibitors

Appendix B-28: Interactions of Quinolone Antibiotics

Appendix B-29: Interactions of SSRIs (Selective Serotonin Reuptake Inhibitors)

Appendix B-30: Interactions of Tetracyclines

Appendix B-31: Interactions of Tricyclic Antidepressants

Appendix B-32: Interactions of Opioid Analgesics

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