Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

Overview

This book overviews in vivo imaging techniques for both the development of drug delivery systems and controlled release dosages. Written by experts in their respective fields, the book discusses applications of quantitative imaging techniques in drug delivery. It helps readers understand the contemporary use of imaging in preclinical evaluation of drug delivery systems and to recognize challenges and potential pitfalls involved in utilizing imaging in developing new drug delivery systems. The chapters provide ...

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Overview

This book overviews in vivo imaging techniques for both the development of drug delivery systems and controlled release dosages. Written by experts in their respective fields, the book discusses applications of quantitative imaging techniques in drug delivery. It helps readers understand the contemporary use of imaging in preclinical evaluation of drug delivery systems and to recognize challenges and potential pitfalls involved in utilizing imaging in developing new drug delivery systems. The chapters provide useful methods, practices, and guidance for pharmaceutical scientists encountering challenges in designing and evaluating drug delivery systems.

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Product Details

  • ISBN-13: 9780470633472
  • Publisher: Wiley
  • Publication date: 11/4/2013
  • Edition number: 1
  • Pages: 494
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

CHUN LI, PhD, is Professor and Ad Interim Chief, Chemistry Section, in the Department of Cancer Systems Imaging at the University of Texas MD Anderson Cancer Center. He is Associate Editor of Cancer Nanotechnology and a member of the editorial boards of American Journal of Nuclear Medicine and Molecular Imaging and Quantitative Imaging in Medicine and Surgery. Dr. Li has more than 120 peer-reviewed publications and holds twenty-eight patents.

MEI TIAN, MD, is Vice President of Hangzhou Binjiang Hospital and Professor of Diagnostic Imaging and Nuclear Medicine at The Second Hospital, Zhejiang University School of Medicine. Dr. Tian is also an editorial consultant for The Lancet. She is a member of the editorial boards of Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Nuclear Medicine Communications, and Oncology.

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Table of Contents

Preface ix

contributors xi

1 Introduction to Molecular Imaging 1
Vikas Kundra

2 PET/SPECT: Instrumentation and Imaging Techniques 12
Yuan-Chuan Tai

3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45
Liang Song and Lihong V. Wang

4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70
Tatyana Chernenko, Lara Milane, Christian Matthäus, Max Diem, and Mansoor Amiji

5 A natomical and Functional MRI91
Edward F. Jackson

6 Quantitative Imaging in Drug Delivery 125
Kooresh I. Shoghi

7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147
Stephen M. Moerlein and Zhude Tu

8 Imaging Peptides, Proteins, and Antibody Delivery 192
Frederik L. Giesel and Clemens Kratochwil

9 In Vivo Imaging and Delivery of siRNA199
Zdravka Medarova and Anna Moore

10 Imaging Cell Therapy 223
Yajie Liang and Jeff W. M. Bulte

11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252
William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins

12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268
Jun Zhao and Chun Li

13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296
G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline

14 Cancer Theranostics with Hollow Gold Nanospheres 308
Wei Lu and Chun Li

15 Imaging Pulmonary Drug Delivery 333
Stephen P. Newman

16 In Vivo Imaging for Validation of Oral Dose Performance 367
Fiona J. McInnes and Howard N. E. Stevens

17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389
Rajesh K. Uthamanthil and Mei Tian

18 Imaging Transcatheter Delivery to Liver Tumors 412
Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426
Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432
Chi-Ming Lee, Katarina Varnäs, and Lars Farde

Index 449

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