Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

Overview

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of ...

See more details below
Other sellers (Hardcover)
  • All (10) from $123.74   
  • New (9) from $123.74   
  • Used (1) from $156.82   

Overview

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

  • In vivo imaging techniques and quantitative analysis
  • Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles
  • Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery
  • Translational research leading to clinical applications
  • Imaging drug delivery in large animal models
  • Clinical applications of imaging techniques to guide drug development and drug delivery

Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.

Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Read More Show Less

Product Details

  • ISBN-13: 9780470633472
  • Publisher: Wiley
  • Publication date: 11/4/2013
  • Edition number: 1
  • Pages: 494
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

CHUN LI, PhD, is Professor and Ad Interim Chief, Chemistry Section, in the Department of Cancer Systems Imaging at the University of Texas MD Anderson Cancer Center. He is Associate Editor of Cancer Nanotechnology and a member of the editorial boards of American Journal of Nuclear Medicine and Molecular Imaging and Quantitative Imaging in Medicine and Surgery. Dr. Li has more than 120 peer-reviewed publications and holds twenty-eight patents.

MEI TIAN, MD, is Vice President of Hangzhou Binjiang Hospital and Professor of Diagnostic Imaging and Nuclear Medicine at The Second Hospital, Zhejiang University School of Medicine. Dr. Tian is also an editorial consultant for The Lancet. She is a member of the editorial boards of Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Nuclear Medicine Communications, and Oncology.

Read More Show Less

Table of Contents

Preface ix

contributors xi

1 Introduction to Molecular Imaging 1
Vikas Kundra

2 PET/SPECT: Instrumentation and Imaging Techniques 12
Yuan-Chuan Tai

3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45
Liang Song and Lihong V. Wang

4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70
Tatyana Chernenko, Lara Milane, Christian Matthäus, Max Diem, and Mansoor Amiji

5 A natomical and Functional MRI91
Edward F. Jackson

6 Quantitative Imaging in Drug Delivery 125
Kooresh I. Shoghi

7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147
Stephen M. Moerlein and Zhude Tu

8 Imaging Peptides, Proteins, and Antibody Delivery 192
Frederik L. Giesel and Clemens Kratochwil

9 In Vivo Imaging and Delivery of siRNA199
Zdravka Medarova and Anna Moore

10 Imaging Cell Therapy 223
Yajie Liang and Jeff W. M. Bulte

11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252
William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins

12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268
Jun Zhao and Chun Li

13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296
G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline

14 Cancer Theranostics with Hollow Gold Nanospheres 308
Wei Lu and Chun Li

15 Imaging Pulmonary Drug Delivery 333
Stephen P. Newman

16 In Vivo Imaging for Validation of Oral Dose Performance 367
Fiona J. McInnes and Howard N. E. Stevens

17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389
Rajesh K. Uthamanthil and Mei Tian

18 Imaging Transcatheter Delivery to Liver Tumors 412
Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426
Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432
Chi-Ming Lee, Katarina Varnäs, and Lars Farde

Index 449

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)