Drug Delivery: Principles and Applications / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
Used and New from Other Sellers
Used and New from Other Sellers
from $97.10
Usually ships in 1-2 business days
(Save 41%)
Other sellers (Hardcover)
  • All (11) from $97.10   
  • New (7) from $127.53   
  • Used (4) from $97.10   


An indispensable tool for those working at the front lines of new drug development
Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery.
Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures.
Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery

Read More Show Less

Editorial Reviews

From the Publisher
“…this text provides an excellent overview…” (Chemistry & Industry, No 24, 19th December 2005)

“…a concise but highly readable text…I recommend this well presented and well written book…” (Chemistry World, Vol. 2 (10), October 2005)

"...the broad overview of drug delivery technology presented in this book makes it well suited as a reference volume…" (E-STREAMS, September 2005)

"…systematically examines various subject areas important to drug delivery." (Drug Discovery & Development, June 2005)

Read More Show Less

Product Details

Meet the Author

BINGHE WANG, PhD, is a professor and Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scientist in the Department of Chemistry, Georgia State University. He is Editor in Chief of Medicinal Research Reviews and a member of the Long-Range Planning Committee of the American Chemical Society, Division of Medicinal Chemistry.

TERUNA SIAHAAN, PhD, is a professor in the Pharmaceutical Chemistry Department, University of Kansas, and a Fellow of the American Association of Pharmaceutical Scientists.

RICHARD A. SOLTERO, PhD, President of PharmaDirections, Inc., is an executive- level scientist with extensive experience managing multisite and multinational pharmaceutical and biotechnology labs.

Read More Show Less

Read an Excerpt

Click to read or download

Read More Show Less

Table of Contents


List of Contributors.

1. Factors that Impact the Developability of Drug Candidates-An Overview (Chao Han and Binghe Wang).

2. Chemical, Biochemical, and Physiological Barriers to Oral Drug Delivery (Teruna Siahaan).

3. Pathways for Drug Delivery to the Central Nervous System (Yan Zhang and Donald W. Miller).

4. Physiochemical Properties, Formulation and Drug Delivery (E. Munson).

5. Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery (William F. Elmquist).

6. Pre-Systemic and First-pass Metabolism (W. Griffith Humphreys).

7. Cell Culture Models for Drug Transport Studies (D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasabdabi, Amber M. Young, Erik Rytting, Bradley Yops and Kenneth L. Audus).

8. Prodrug Approaches to Drug Delivery (Longqin Hu).

9. Receptor-Mediated Drug Delivery (Chirstopher P. Leamon and Philip S. Low).

10. Oral Protein and Peptide Drug Delivery (Rick Soltero).

11. Metabolic Activation and Drug Targeting (Xiangming Guan).

12. Ultrasound Mediated Drug Delivery (Ka-yun Ng’ and Terry O. Matsunaga).

13. Polycationic Peptides and Proteins in Drug Delivery: Focus on Non-Classical Transport (Lisa A. Kueltzo and C. Russell Middaugh).

14. Gene Therapy and Gene Delivery (Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura).

15. Parenteral Formulations for Peptide and Protein Delivery, and Monoclone Antibody Drugs (John Bontempo).

16. Pulmonary Drug Delivery – Pharmaceutical Chemistry and Aerosol Technology (Anthony J. Hickey).

17. Antibody-Directed Drug Delivery (Hervé Le Calvez, John Mountzouris, Kosi Gramatikoff and Fang Fang).

18. Efflux Transporters in Drug Excretion (Shuzhong Zhang and Marilyn E. Morris).

19. Liposome as Drug Delivery Vehicles (Guijun Wang).

20. Regulatory and IP Issues in Drug Delivery Research (Shihong Nicolaou).


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)