Drug Delivery Systems / Edition 1

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Methods in Molecular Biology TM 437
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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This is a how-to book of cutting-edge technologies in drug delivery systems written by a team of experts in pharmaceutical sciences from academia and industry.
Purpose: The aim is to publish descriptions of selective technologies used in drug delivery systems. Important new technologies, such as nanoparticles, and new therapeutic applications are included. This goal is well developed by these experts.
Audience: This book is written for pharmaceutical scientists working in academia or industry. It contains useful information for pharmaceutical physicians and scientists in many disciplines, including chemical engineering, protein engineering, and gene therapy, who have an interest in drug delivery systems.
Features: A concise overview of drug delivery systems begins the book, followed by chapters dealing with the use of adeno-associated virus capsid in gene transfer, delivering small interfering RNAs for novel therapeutic actions, the use of catheters for the chronic administration of drugs into brain tissues, transdermal drug delivery systems, protein particles that are engineered for pulmonary drug delivery, a new technology to deliver drugs across the blood-brain barrier, the use of liposomal technology for the delivery of anticancer drugs, the use of pH responsive nanoparticles for the delivery of anticancer drugs, and advances in extended-release technologies for oral medications. Each chapter discusses the principles, detailed experimental protocols, and results of drug delivery of the technique.
Assessment: This is a powerful reference that provides concise and systematic description of drug delivery technologies that should be useful for the many companies developing drug delivery technologies as well as academicians who are investigating the principles of drug delivery systems.
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Product Details

  • ISBN-13: 9781588298911
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 2/22/2008
  • Series: Methods in Molecular Biology Series, #437
  • Edition description: 2008
  • Edition number: 1
  • Pages: 251
  • Product dimensions: 6.10 (w) x 9.30 (h) x 0.90 (d)

Table of Contents

Preface v

Contributors ix

1 Drug Delivery Systems - An Overview Kewal K. Jain 1

2 The Role of the Adeno-Associated Virus Capsid in Gene Transfer Kim M. Van Vliet Veronique Blouin Nicole Brument Mavis Agbandje-McKenna Richard O. Snyder 51

3 Delivering Small Interfering RNA for Novel Therapeutics Patrick Y. Lu Martin C. Woodle 93

4 Catheters for Chronic Administration of Drugs into Brain Tissue Michael Guarnieri Benjamin S. Carson George I. Jallo 109

5 Transdermal Drug Delivery Systems: Skin Perturbation Devices Marc B. Brown Matthew J. Traynor Gary P. Martin Franklin K. Akomeah 119

6 Controlling the Release of Proteins/Peptides via the Pulmonary Route Sunday A. Shoyele 141

7 Engineering Protein Particles for Pulmonary Drug Delivery Sunday A. Shoyele 149

8 2B-Trans TM Technology: Targeted Drug Delivery Across the Blood-Brain Barrier Pieter J. Gaillard Albertus G. de Boer 161

9 Drug Delivery in Cancer Using Liposomes Crispin R. Dass 177

10 pH-Responsive Nanoparticles for Cancer Drug Delivery Youqing Shen Huadong Tang Maciej Radosz Edward Van Kirk William J. Murdoch 183

11 Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems Sandip B. Tiwari Ali R. Rajabi-Siahboomi 217

Index 245

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